UPLC-MS/MS Simultaneous Determination of Methamphetamine, Amphetamine, Morphine, Monoacetylmorphine, Ketamine, Norketamine, MDMA, and MDA in Hair

doi:10.1556/1326.2019.00615

科研成果详情

题名	UPLC-MS/MS Simultaneous Determination of Methamphetamine, Amphetamine, Morphine, Monoacetylmorphine, Ketamine, Norketamine, MDMA, and MDA in Hair
作者	Chen, Siyuan 1,2; Ma, Jianshe1; Wang, Xianqin1,2; Geng, Peiwu 3
发表日期	2020-06
发表期刊	ACTA CHROMATOGRAPHICA 影响因子和分区
语种	英语
原始文献类型	Article
关键词	UPLC-MS/MS methamphetamine amphetamine morphine. monoacetylmorphine ketamine nark mine MDMA MDA hair
其他关键词	CHROMATOGRAPHY-MASS-SPECTROMETRY ; RAT PLASMA ; LIQUID-CHROMATOGRAPHY ; DRUGS ; PHARMACOKINETICS ; ABUSE
摘要	Hair is a stable specimen and has a longer detection window (from weeks to months) than blood and urine. Through the analysis of hair, the long-term information of the drug use of the identified person could he explored. Our work is to establish an ultra-performance liquid chromatography tandem mass spectroscopy (UPLC-MS/MS) method for simultaneous determination of methamphetamine, amphetamine, morphine, monoacetylmorphine, ketamine, norketamine, 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyamphetamine (MDA) in hair. Methoxyphenamine was used as an internal standard. The chromatographic separation was performed on a UPLC ethylene bridged hybrid (BEH) C18 (2.1 mm x 50 mm, 1.7 mu m) column using a mobile phase of acetonitrite water with 10 mmol/L ammonium acetate solution which containing 0.05% ammonium hydroxide. The multiple reaction monitoring in positive electrospray ionization was used for quantitative determination. The infra-day and inter-day precisions (relative standard deviation [RSD) were below 15%. The accuracy ranged between 85.5% and 110.4%, the average recovery rate was above 72.9%, and the matrix effect ranged between 92.7% and 109.2%. Standard curves were in the range of 0.05-5.0 ng/mg, and the correlation coefficients were greater than 0.995. The established UPLC MS/MS method was applied to analyze the hair samples successfully.
资助项目	Wenzhou Medical University [QTJ17018]
出版者	AKADEMIAI KIADO ZRT
出版地	BUDAPEST
ISSN	1233-2356
EISSN	2083-5736
卷号	32 期号:2 页码:145-148
DOI	10.1556/1326.2019.00615
页数	4
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
WOS记录号	WOS:000523183500012
收录类别	SCIE ; SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-85089845378
通讯作者地址	[Wang, Xianqin]School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China ; [Wang, Xianqin]Institute of Forensic Science,Wenzhou Medical University,Wenzhou,325035,China ; [Geng, Peiwu]Laboratory of Clinical Pharmacy,People's Hospital of Lishui,Lishui,323000,China
Scopus学科分类	Chemistry (all)
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/3950
专题	药学院（分析测试中心）基础医学院（机能实验教学中心）_法医学系
通讯作者	Wang, Xianqin; Geng, Peiwu
作者单位	1.School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China; 2.Institute of Forensic Science,Wenzhou Medical University,Wenzhou,325035,China; 3.Laboratory of Clinical Pharmacy,People's Hospital of Lishui,Lishui,323000,China
第一作者单位	药学院（分析测试中心）; 温州医科大学
通讯作者单位	药学院（分析测试中心）; 温州医科大学
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Chen, Siyuan,Ma, Jianshe,Wang, Xianqin,et al. UPLC-MS/MS Simultaneous Determination of Methamphetamine, Amphetamine, Morphine, Monoacetylmorphine, Ketamine, Norketamine, MDMA, and MDA in Hair[J]. ACTA CHROMATOGRAPHICA,2020,32(2):145-148.
APA	Chen, Siyuan, Ma, Jianshe, Wang, Xianqin, & Geng, Peiwu. (2020). UPLC-MS/MS Simultaneous Determination of Methamphetamine, Amphetamine, Morphine, Monoacetylmorphine, Ketamine, Norketamine, MDMA, and MDA in Hair. ACTA CHROMATOGRAPHICA, 32(2), 145-148.
MLA	Chen, Siyuan,et al."UPLC-MS/MS Simultaneous Determination of Methamphetamine, Amphetamine, Morphine, Monoacetylmorphine, Ketamine, Norketamine, MDMA, and MDA in Hair".ACTA CHROMATOGRAPHICA 32.2(2020):145-148.