Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles

doi:10.1016/j.biomaterials.2011.07.032

科研成果详情

题名	Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles
作者	Wang, Hai 1; Zhao, Ying 1; Wu, Yan 1; Hu, Yu-lin 2; Nan, Kaihui3; Nie, Guangjun 1; Chen, Hao 3
发表日期	2011-11-01
发表期刊	Biomaterials 影响因子和分区
语种	英语
原始文献类型	Journal article (JA)
关键词	Biocompatibility Emulsification Liposomes Micelles Nanoparticles Nanotechnology Polyethylene glycols Polyethylene oxides Targeted drug delivery Tumors Amphiphilic co-polymers Chemotherapeutic drugs Co deliveries Controlled drug release Double emulsions Methoxypolyethylene glycol Multi-functional nanoparticles Poly lactide-co-glycolide
摘要	The use of single chemotherapeutic drug has shown some limitations in anti-tumor treatment, such as development of drug resistance, high toxicity and limited regime of clinical uses. The combination of two or more therapeutic drugs is feasible means to overcome the limitations. Co-delivery strategy has been proposed to minimize the amount of each drug and to achieve the synergistic effect for cancer therapies. Attempts have been made to deliver chemotherapeutic drugs simultaneously using drug carriers, such as micelles, liposomes, and inorganic nanoparticles (NPs). Here we reported core-shell NPs that were doubly emulsified from an amphiphilic copolymer methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) (mPEG-PLGA). These NPs offered advantages over other nanocarriers, as they were easy to fabricate by improved double emulsion method, biocompatible, and showed high loading efficacy. More importantly, these NPs could co-deliver hydrophilic doxorubicin (DOX) and hydrophobic paclitaxel (TAX). The drug-loaded NPs possessed a better polydispersity, indicating that they are more readily subject to controlled size distribution. Studies on drug release and cellular uptake of the co-delivery system demonstrated that both drugs were effectively taken up by the cells and released simultaneously. Furthermore, the co-delivery nanocarrier suppressed tumor cells growth more efficiently than the delivery of either DOX or TAX at the same concentrations, indicating a synergistic effect. Moreover, the NPs loading drugs with a DOX/TAX concentration ratio of 2:1 showed the highest anti-tumor activity to three different types of tumor cells. This nanocarrier might have important potential in clinical implications for co-delivery of multiple anti-tumor drugs with different properties. © 2011 Elsevier Ltd.
资助项目	MOST 863 program[2007AA021807];NSFC[10979011,30900278];MOST 973 program[2010CB933600,2010CB934004,2011CB9334000]
出版者	Elsevier Ltd
ISSN	0142-9612
EISSN	1878-5905
卷号	32 期号:32 页码:8281-8290
DOI	10.1016/j.biomaterials.2011.07.032
收录类别	EI ; SCOPUS
EI入藏号	20113614310871
EI主题词	Controlled drug delivery
URL	查看原文
PubMed ID	21807411
SCOPUSEID	2-s2.0-80052386569
自科自定义期刊分类	T3(B)类
通讯作者地址	[Nie, Guangjun]CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology,China
Scopus学科分类	Bioengineering;Ceramics and Composites;Biophysics;Biomaterials;Mechanics of Materials
TOP期刊	TOP期刊
引用统计	被引频次：492[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/35035
专题	眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者	Nie, Guangjun
作者单位	1.CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology,China; 2.The First Affiliated Hospital of Jilin University,Changchun,China; 3.Eye Hospital of Wenzhou Medical College,Key Laboratory for Ophthalmology and Optometry of Zhejiang Province,China
推荐引用方式 GB/T 7714	Wang, Hai,Zhao, Ying,Wu, Yan,et al. Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles[J]. Biomaterials,2011,32(32):8281-8290.
APA	Wang, Hai., Zhao, Ying., Wu, Yan., Hu, Yu-lin., Nan, Kaihui., ... & Chen, Hao. (2011). Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles. Biomaterials, 32(32), 8281-8290.
MLA	Wang, Hai,et al."Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles".Biomaterials 32.32(2011):8281-8290.