题名 | Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles |
作者 | |
发表期刊 | Biomaterials 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Journal article (JA) |
关键词 | Biocompatibility Emulsification Liposomes Micelles Nanoparticles Nanotechnology Polyethylene glycols Polyethylene oxides Targeted drug delivery Tumors Amphiphilic co-polymers Chemotherapeutic drugs Co deliveries Controlled drug release Double emulsions Methoxypolyethylene glycol Multi-functional nanoparticles Poly lactide-co-glycolide |
摘要 | The use of single chemotherapeutic drug has shown some limitations in anti-tumor treatment, such as development of drug resistance, high toxicity and limited regime of clinical uses. The combination of two or more therapeutic drugs is feasible means to overcome the limitations. Co-delivery strategy has been proposed to minimize the amount of each drug and to achieve the synergistic effect for cancer therapies. Attempts have been made to deliver chemotherapeutic drugs simultaneously using drug carriers, such as micelles, liposomes, and inorganic nanoparticles (NPs). Here we reported core-shell NPs that were doubly emulsified from an amphiphilic copolymer methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) (mPEG-PLGA). These NPs offered advantages over other nanocarriers, as they were easy to fabricate by improved double emulsion method, biocompatible, and showed high loading efficacy. More importantly, these NPs could co-deliver hydrophilic doxorubicin (DOX) and hydrophobic paclitaxel (TAX). The drug-loaded NPs possessed a better polydispersity, indicating that they are more readily subject to controlled size distribution. Studies on drug release and cellular uptake of the co-delivery system demonstrated that both drugs were effectively taken up by the cells and released simultaneously. Furthermore, the co-delivery nanocarrier suppressed tumor cells growth more efficiently than the delivery of either DOX or TAX at the same concentrations, indicating a synergistic effect. Moreover, the NPs loading drugs with a DOX/TAX concentration ratio of 2:1 showed the highest anti-tumor activity to three different types of tumor cells. This nanocarrier might have important potential in clinical implications for co-delivery of multiple anti-tumor drugs with different properties. © 2011 Elsevier Ltd. |
出版者 | Elsevier Ltd |
ISSN | 0142-9612 |
EISSN | 1878-5905 |
卷号 | 32期号:32页码:8281-8290 |
DOI | 10.1016/j.biomaterials.2011.07.032 |
收录类别 | EI |
发表日期 | 2011-11-01 |
EI入藏号 | 20113614310871 |
EI主题词 | Controlled drug delivery |
自科自定义期刊分类 | T3(B)类 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/35035 |
专题 | 眼视光学院(生物医学工程学院)、附属眼视光医院 |
作者单位 | 1.CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China; 2.The First Affiliated Hospital of Jilin University, Changchun, Jilin Province 130021, China; 3.Eye Hospital of Wenzhou Medical College, Key Laboratory for Ophthalmology and Optometry of Zhejiang Province, Wenzhou, China |
推荐引用方式 GB/T 7714 | Wang, Hai,Zhao, Ying,Wu, Yan,et al. Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles[J]. Biomaterials,2011,32(32):8281-8290. |
APA | Wang, Hai., Zhao, Ying., Wu, Yan., Hu, Yu-lin., Nan, Kaihui., ... & Chen, Hao. (2011). Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles. Biomaterials, 32(32), 8281-8290. |
MLA | Wang, Hai,et al."Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles".Biomaterials 32.32(2011):8281-8290. |
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