[Effect of intravenous infusion with lidocaine on rapid recovery of laparoscopic cholecystectomy]

doi:10.3760/cma.j.issn.0376-2491.2017.12.012

科研成果详情

题名	[Effect of intravenous infusion with lidocaine on rapid recovery of laparoscopic cholecystectomy]
其他题名	Effect of intravenous infusion with lidocaine on rapid recovery of laparoscopic cholecystectomy
作者	X Z Chen; Q B Lou; C C Sun; W S Zhu; J Li
发表日期	2017-03-28
发表期刊	Zhonghua yi xue za zhi 影响因子和分区
语种	英语
原始文献类型	期刊论文
关键词	Cholecystectomy, laparoscopic Injections, intravenous Lidocaine Postoperative period Rehabilitation.
其他关键词	Injections ; intravenous ; Lidocaine ; Postoperative period ; Rehabilitation ; Cholecystectomy ; laparoscopic
摘要	Objective: To investigate the effect of intravenous infusion with lidocaine on rapid recovery of laparoscopic cholecystectomy. Methods: This study was a prospective randomized controlled trial. From February to August 2016 in Affiliated Yiwu Hospital of Wenzhou Medical University, 60 patients scheduled for laparoscopic cholecystectomy under general anesthesia were involved and randomly divided into control group (n=30) and lidocaine group (n=30). Patients in lidocaine group received lidocaine 1.5 mg/kg intravenously before induction and followed by 2.0 mg·kg(-1)·h(-1) to the end of surgery. Patients in control group received equal volumes of saline intravenously. Anesthesia induction in both groups were given intravenous midazolam 0.03 mg/kg, sufentanil 0.2 μg/kg, propofol 2.0 mg/kg and cisatracuium 0.2 mg/kg. Anesthesia was maintained with propofol 0.05-0.20 mg·kg(-1)·min(-1) and remifentanil 0.1-0.5 μg·kg(-1)·min(-1) for laryngeal mask airway which bispectral index (BIS) value maintained at 40-60. BIS, heart rate(HR) and mean arterial pressure(MAP) were recorded before anesthesia induction, before and immediately after laryngeal mask implantation, intraoperative 30 min and anesthesia awake. Pain scores were assessed using visual analogue scales (VAS) at postoperation immediately, 30 min during postanesthesia care unit (PACU), 2, 6, 12, and 24 h after surgery. The time of PACU retention, postoperative ambulation, first intestine venting and discharge were recorded. The dosage of propofol and remifentanil, the frequency of sufentanil used, the incidence of postoperative nausea and vomiting were also recorded. Patient satisfaction was evaluated by using Simple Restoration Quality Score (QoR-9). Results: BIS values before and after laryngeal mask implantation in lidocaine group were 50.50±3.47 and 54.63±1.25 respectively, which was lower than those in control group(54.30±4.78, 55.80±2.33; t=3.542, 2.423, all P<0.05). The VAS score at postoperation immediately, PACU 30 min, postoperative 2, 6, 12 h in lidocaine group were 2.76±0.97, 2.37±0.93, 2.10±1.12, 1.76±0.97, 1.20±0.76 respectively, which was lower than those in control group (3.83±1.34, 3.27±1.26, 3.06±1.20, 2.63±0.88, 1.90±0.84; t=3.528, 3.154, 3.217, 3.603, 3.372, all P<0.05 ). The frequency of additional sufentanil at postoperation immediately and PACU 30 min in lidocaine group was 5(17%), 3(10%), which were less than those in control group(12(40%), 9(30%); χ(2)=4.022, 3.950, all P<0.05). The dosage of propofol and remifentanil in lidocaine group were (4.33±0.75) mg·kg(-1)·h(-1) and (9.00±1.66) μg·kg(-1)·h(-1) respectively, which were less than those in control group ((5.20±1.39) mg·kg(-1)·h(-1) and (10.43±2.20) μg·kg(-1)·h(-1;) t= 2.982, 2.842, all P<0.05). The time of PACU retention, postoperative ambulation and first intestine venting were (39.90 ± 8.06) min, (11.93±1.68) h and (10.16±1.05) h respectively in lidocaine group, which were shorter than those in control group ((48.23±10.04) min, (13.16±1.58) h and (11.13±1.30) h; t=3.514, 2.931, 3.156, all P<0.05). The QoR-9 score in lidocaine group was 15.60±1.07, which was higher than that in control group(14.73±0.74, t=-3.649, P<0.05). There was no significant difference in the incidence of postoperative nausea/vomiting and the discharge time between two groups (all P>0.05). Conclusion: Intravenous infusion of lidocaine can effectively reduce the dosages of propofol and remifentanil, postoperative early VAS score, postoperative ambulation time and first intestine venting time which could improve the satisfaction of patients.
其他摘要	Objective To investigate the effect of intravenous infusion with lidocaine on rapid recovery of laparoscopic cholecystectomy. Methods This study was a prospective randomized controlled trial. From February to August 2016 in Affiliated Yiwu Hospital of Wenzhou Medical University, 60 patients scheduled for laparoscopic cholecystectomy under general anesthesia were involved and randomly divided into control group ( n = 30) and lidocaine group ( n = 30) . Patients in lidocaine group received lidocaine 1. 5 mg/kg intravenously before induction and followed by 2. 0 mg ·kg~(-1) · h~(-1) to the end of surgery. Patients in control group received equal volumes of saline intravenously. Anesthesia induction in both groups were given intravenous midazolam 0. 03 mg/kg, sufentanil 0. 2 μg/kg, propofol 2. 0 mg/kg and cisatracuium 0. 2 mg/kg. Anesthesia was maintained with propofol 0.05 - 0.20 mg · kg~(-1) · min~(-1) and remifentanil 0. 1 -0. 5 μg · kg~(-1) · min~(-1) for laryngeal mask airway which bispectral index ( BIS) value maintained at 40 - 60. BIS, heart rate( HR) and mean arterial pressure( MAP) were recorded before anesthesia induction, before and immediately after laryngeal mask implantation,intraoperative 30 min and anesthesia awake. Pain scores were assessed using visual analogue scales ( VAS) at postoperation immediately,30 min during postanesthesia care unit ( PACU) , 2,6, 12,and 24 h after surgery. The time of PACU retention, postoperative ambulation, first intestine venting and discharge were recorded. The dosage of propofol and remifentanil, the frequency of sufentanil used, the incidence of postoperative nausea and vomiting were also recorded. Patient satisfaction was evaluated by using Simple Restoration Quality Score ( QoR-9 ) . Results BIS values before and after laryngeal mask implantation in lidocaine group were 50. 50 ± 3. 47 and 54. 63 ± 1. 25 respectively, which was lower than those in control group (54. 30 ± 4. 78,55. 80 ± 2. 33 ; t =3. 542,2. 423,all P <0. 05). The VAS score at postoperation immediately, PACU 30 min, postoperative 2,6,12 h in lidocaine group were 2. 76 ±0.97,2. 37 ±0.93,2. 10 ± 1. 12, 1.76 ±0.97,1.20 ±0.76 respectively,which was lower than those in control group (3. 83 ± 1. 34,3. 27 ± 1. 26,3. 06 ± 1. 20,2. 63 ±0. 88,1. 90 ± 0.84; t =3.528, 3. 154,3.217, 3.603,3.372,all P <0.05 ). The frequency of additional sufentanil at postoperation immediately and PACU 30 min in lidocaine group was 5( 17% ) ,3( 10% ),which were less than those in control group (12 (40% ),9( 30% ); χ~2 =4. 022,3. 950,all P<0.05). The dosage of propofol and remifentanil in lidocaine group were (4. 33 ± 0. 75 ) mg . kg~(-1) · h~(-1) and (9. 00 ± 1. 66) μg · kg_ 1 · h_ 1 respectively, which were less than those in control group ( (5. 20 ± 1. 39) mg · kg~(-1) · h~(-1) and (10. 43 ± 2.20) μg · kg~(-1) . h~(-1); t = 2.982, 2.842, all P <0.05). The time of PACU retention, postoperative ambulation and first intestine venting were (39. 90 ± 8. 06) min, ( 11. 93 ± 1. 68) h and (10. 16 ± 1. 05) h respectively in lidocaine group, which were shorter than those in control group ((48. 23± 10.04) min, (13. 16±1.58) h and (11. 13 ± 1.30) h; t =3.514,2.931,3. 156, all P <0.05).The QoR-9 score in lidocaine group was 15. 60 ± 1. 07, which was higher than that in control group (14. 73 ±0. 74,t = -3. 649,P < 0. 05 ) . There was no significant difference in the incidence of postoperative nausea/vomiting and the discharge time between two groups ( all P >0. 05 ) . Conclusion Intravenous infusion of lidocaine can effectively reduce the dosages of propofol and remifentanil, postoperative early VAS score, postoperative ambulation time and first intestine venting time which could improve the satisfaction of patients.
ISSN	0376-2491
卷号	97 期号:12 页码:934-939.
DOI	10.3760/cma.j.issn.0376-2491.2017.12.012
页数	6
收录类别	PUBMED ; CSCD ; 万方 ; SCOPUS ; PKU ; 北大核心 ; ISTIC
学科领域	医药、卫生
URL	查看原文
CSCD记录号	CSCD:5951675
PubMed ID	28355756
SCOPUSEID	2-s2.0-85049253647
Scopus学科分类	Medicine (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/34524
专题	第二临床医学院，附属第二医院、育英儿童医院_麻醉学_麻醉科
作者单位	Department of Anesthesiology, the Second Affiliated Hospital and Yuying Children&s Hospital of Wenzhou Medical University, Wenzhou 325027, China.
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院_麻醉学_麻醉科
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院_麻醉学_麻醉科
推荐引用方式 GB/T 7714	X Z Chen,Q B Lou,C C Sun,et al. [Effect of intravenous infusion with lidocaine on rapid recovery of laparoscopic cholecystectomy][J]. Zhonghua yi xue za zhi,2017,97(12):934-939..
APA	X Z Chen, Q B Lou, C C Sun, W S Zhu, & J Li. (2017). [Effect of intravenous infusion with lidocaine on rapid recovery of laparoscopic cholecystectomy]. Zhonghua yi xue za zhi, 97(12), 934-939..
MLA	X Z Chen,et al."[Effect of intravenous infusion with lidocaine on rapid recovery of laparoscopic cholecystectomy]".Zhonghua yi xue za zhi 97.12(2017):934-939..