[Lack of progesterone receptor expression predicts poor prognosis in patients with operable ER-positive invasive breast cancer]

doi:10.3760/cma.j.issn.0253-3766.2016.09.010

科研成果详情

题名	[Lack of progesterone receptor expression predicts poor prognosis in patients with operable ER-positive invasive breast cancer]
其他题名	Lack of progesterone receptor expression predicts poor prognosis in patients with operable ER- positive invasive breast cancer
作者	R M Ma 1; C Z Chen 2; C Q Lin 2; W Zhang2; G L Guo 2
发表日期	2016-09-23
发表期刊	Zhonghua zhong liu za zhi [Chinese journal of oncology] 影响因子和分区
语种	英语
原始文献类型	期刊论文
关键词	乳腺肿瘤孕激素受体雌激素受体预后
其他关键词	Breast neoplasm ; Progesterone receptor ; Estrogen receptor ; Prognosis
摘要	Objective:To investigate the impact of lack of progesterone receptor (PR) expression on the prognosis of patients with operable ER (estrogen receptor)-positive invasive breast cancer. Methods:We retrospectively analyzed the clinicopathological features, treatment and survival data of 318 women with ER+ /PR+ and ER+ /PR- invasive breast cancer. Results:Among the 318 patients, there were 219 PR-positive and 99 PR-negative cases. The 5-year overall survival (OS) rate was 92.5%, and the 5-year disease-free survival (DFS) rate was 87.2% in the 318 ER-positive patients. Among them, the 5-year OS rates were significantly different between the PR-positive group (94.6%) and PR-negative group (87.8%, P=0.020), and the 5-year DFS rates were also significantly different from each other (89.8% and 81.6%, respectively, P=0.019). Univariate analysis showed that PR status, tumor size, T stage, axillary lymph node metastasis, and clinical stage were prognostic factors for OS (P<0.05 for all). Multivariate analysis showed that lack of PR expression, T stage ≥2, and positive axillary lymph node metastasis were independent risk factors for poor DFS and OS in ER-positive breast cancer patients (P<0.05 for all). Subgroup analysis showed that lack of PR expression was not significant in predicting poor DFS or OS when patients were in stage Ⅰ or with a small tumor (≤2 cm) (P>0.05 for all), and also showed that premenopausal women with PR-negative disease had poorer DFS and OS than PR-positive patients (P<0.05 for both). Conclusions:Lack of PR expression is an independent risk factor for poor prognosis in patients with operable ER-positive invasive breast cancer, especially in patients with a large tumor (>2 cm), advanced clinical stage (Stage Ⅱ or Ⅲ) or in premenopausal status.
其他摘要	Objective To investigate the impact of lack of progesterone receptor (PR) expression on the prognosis of patients with operable ER (estrogen receptor)-positive invasive breast cancer. Methods We retrospectively analyzed the clinicopathological features, treatment and survival data of 318 women with ER+/ PR+ and ER+/ PR- invasive breast cancer. Results Among the 318 patients, there were 219 PR- positive and 99 PR-negative cases. The 5-year overall survival (OS) rate was 92.5%, and the 5-year disease-free survival (DFS) rate was 87.2% in the 318 ER-positive patients. Among them, the 5-year OS rates were significantly different between the PR-positive group (94.6%) and PR-negative group (87.8%, P =0.020), and the 5-year DFS rates were also significantly different from each other (89.8% and 81.6%, respectively, P =0.019).Univariate analysis showed that PR status, tumor size, T stage, axillary lymph node metastasis, and clinical stage were prognostic factors for OS (P<0.05 for all). Multivariate analysis showed that lack of PR expression, T stage ≥2, and positive axillary lymph node metastasis were independent risk factors for poor DFS and OS in ER-positive breast cancer patients (P < 0.05 for all). Subgroup analysis showed that lack of PR expression was not significant in predicting poor DFS or OS when patients were in stage Ⅰ or with a small tumor (≤2 cm) (P>0.05 for all), and also showed that premenopausal women with PR-negative disease had poorer DFS and OS than PR-positive patients (P<0.05 for both). Conclusions Lack of PR expression is an independent risk factor for poor prognosis in patients with operable ER-positive invasive breast cancer, especially in patients with a large tumor (>2 cm), advanced clinical stage (Stage Ⅱ or Ⅲ) or in premenopausal status.
资助项目	浙江省自然科学基金
ISSN	0253-3766
卷号	38 期号:9 页码:687-92.
DOI	10.3760/cma.j.issn.0253-3766.2016.09.010
页数	6
收录类别	PUBMED ; CSCD ; 万方 ; SCOPUS ; PKU ; 北大核心 ; ISTIC
学科领域	医药、卫生
URL	查看原文
CSCD记录号	CSCD:5802181
PubMed ID	27647402
SCOPUSEID	2-s2.0-85020374959
Scopus学科分类	Oncology
万方分类号	R737.9(泌尿生殖器肿瘤) ; R34(基础医学) ; R979.1(药品)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/34497
专题	第二临床医学院，附属第二医院、育英儿童医院_外科学_乳腺外科附属第一医院_肿瘤外科
作者单位	1.Department of Breast Surgery, the Second Affiliated Hospital & Yuying Children&s Hospital of Wenzhou Medical University, Wenzhou 325000, China.; 2.Department of Surgical Oncology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院_外科学_乳腺外科
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院_外科学_乳腺外科
推荐引用方式 GB/T 7714	R M Ma,C Z Chen,C Q Lin,et al. [Lack of progesterone receptor expression predicts poor prognosis in patients with operable ER-positive invasive breast cancer][J]. Zhonghua zhong liu za zhi [Chinese journal of oncology],2016,38(9):687-92..
APA	R M Ma, C Z Chen, C Q Lin, W Zhang, & G L Guo. (2016). [Lack of progesterone receptor expression predicts poor prognosis in patients with operable ER-positive invasive breast cancer]. Zhonghua zhong liu za zhi [Chinese journal of oncology], 38(9), 687-92..
MLA	R M Ma,et al."[Lack of progesterone receptor expression predicts poor prognosis in patients with operable ER-positive invasive breast cancer]".Zhonghua zhong liu za zhi [Chinese journal of oncology] 38.9(2016):687-92..