Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps

doi:10.3389/fphar.2022.809034

科研成果详情

题名	Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps
作者	Dong, Chengji1,2,3; Chen, Zhuliu1,2,3; Zhu, Linxin 2,3; Bsoul, Najeeb 1,2; Wu, Hongqiang1,2,3; Jiang, Jingtao 1,2,3; Chen, Xuankuai1,2,3; Lai, Yingying1,2,3; Yu, Gaoxiang1,2,3; Gu, Yanlan4; Guo, Xiaoshan1,2; Gao, Weiyang1,2
发表日期	2022-02-15
发表期刊	Frontiers in pharmacology 影响因子和分区
语种	英语
原始文献类型	Article
关键词	angiogenesis apoptosis autophagy diallyl trisulfide multiterritory perforator flap oxidative stress.
其他关键词	ISCHEMIA-REPERFUSION INJURY ; ENDOPLASMIC-RETICULUM STRESS ; ISCHEMIA/REPERFUSION INJURY ; OXIDATIVE STRESS ; AUTOPHAGY ; ANGIOGENESIS ; VASCULATURE ; APOPTOSIS ; PROTECTS ; CELLS
摘要	The multiterritory perforator flap is one of the widest flap patterns used to repair tissue defects. However, flap necrosis of the distal part is still a challenging issue for plastic surgeons. Diallyl trisulfide (DATS) is an efficient ingredient extracted from garlic, exerting many important effects on different diseases. Our experiment aims to reveal whether DATS has a beneficial effect on the survival of perforator flaps and to explore its mechanism of action. The results showed that DATS enhanced angiogenesis and autophagy and reduced cell apoptosis and oxidative stress, thereby improving the survival rate of skin flaps. After co-administration with autophagy inhibitor 3-methyladenine (3MA), perforator flap survival was further improved. Mechanistically, we showed that PI3K/Akt and AMPK-HIF-1α signaling pathways in flap were activated under DATS treatment. All in all, DATS promoted the survival of multiterritory perforator flaps via the synergistic regulation of PI3K/Akt and AMPK-HIF-1α signaling pathways, and inhibition of DATS-induced autophagy further improves flap survival.
资助项目	National Natural Science Foundation of China[81873942];
出版者	FRONTIERS MEDIA SA
出版地	LAUSANNE
ISSN	1663-9812
EISSN	1663-9812
卷号	13 页码:809034
DOI	10.3389/fphar.2022.809034
页数	13
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:000788225900001
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
PubMed ID	35242032
PMC记录号	PMC8885991
SCOPUSEID	2-s2.0-85125574529
通讯作者地址	[Gao, Weiyang]Department of Orthopaedics,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Pharmacology;Pharmacology (medical)
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/34402
专题	第二临床医学院，附属第二医院、育英儿童医院基础医学院（机能实验教学中心）_形态学系_组织胚胎学
通讯作者	Gao, Weiyang
作者单位	1.Department of Orthopaedics,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China; 2.Zhejiang Provincial Key Laboratory of Orthopaedics,Wenzhou,China; 3.The Second Clinical Medical College,Wenzhou Medical University,Wenzhou,China; 4.Department of Histology and Embryology,Wenzhou Medical University,Zhejiang,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Dong, Chengji,Chen, Zhuliu,Zhu, Linxin,et al. Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps[J]. Frontiers in pharmacology,2022,13:809034.
APA	Dong, Chengji., Chen, Zhuliu., Zhu, Linxin., Bsoul, Najeeb., Wu, Hongqiang., ... & Gao, Weiyang. (2022). Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps. Frontiers in pharmacology, 13, 809034.
MLA	Dong, Chengji,et al."Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps".Frontiers in pharmacology 13(2022):809034.