题名 | Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats |
作者 | |
发表日期 | 2012-11 |
发表期刊 | EXPERIMENTAL LUNG RESEARCH 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | animal model neutrophil elastase inhibitor ONO-5046 pulmonary injury rats |
其他关键词 | NEUTROPHIL ELASTASE INHIBITOR ; ACUTE NECROTIZING PANCREATITIS ; MICE ; ONO-5046 ; MODELS ; SODIUM ; DUCT |
摘要 | The incidence of acute pancreatitis has been rising worldwide in the past few decades. Despite extensive research efforts, the population-based mortality from acute pancreatitis remains high. Since dysfunction of multiple vital organs, most importantly the lungs, is the major cause of early death in acute pancreatitis patients, developing effective strategies to manage lung injury has become one of the focuses of recent research efforts aiming at improving the outcome of patients with acute pancreatitis. In this study, we attempted to create a rat model of acute pancreatitis through intraductal infusion of taurocholate and to evaluate the potential of sivelestat, a synthetic neutrophil elastase inhibitor, in protection against acute pancreatitis-associated lung injury using this rat model. The results demonstrated that: (1) 5% sodium taurocholate successfully induced histopathologic and biochemical abnormalities in the circulation, lung and pancreas characteristic of human acute pancreatitis, including an increase in amylase concentration and a decrease in partial arterial oxygen pressure (PaO2) in the blood, increases in activities of myeloperoxidase (MPO) (a lung injury marker) and neutrophil elastase (a quantitative indicator of neutrophil infiltration), and levels of malondialdehyde (an indicator of lipid peroxidation) and tumor necrosis factor-alpha (a major inflammatory mediator) in the lung; (2) intravenous administration of sivelestat effectively attenuated the taurocholate-induced abnormalities in all parameters analyzed except for serum amylase concentration. Our findings have validated the taurocholate model of acute pancreatitis and demonstrated great therapeutic potential for sivelestat in managing acute pancreatitis-associated lung injury. |
出版者 | INFORMA HEALTHCARE |
出版地 | LONDON |
ISSN | 0190-2148 |
EISSN | 1521-0499 |
卷号 | 38期号:9-10页码:445-452 |
DOI | 10.3109/01902148.2012.721860 |
页数 | 8 |
WOS类目 | Respiratory System |
WOS研究方向 | Respiratory System |
WOS记录号 | WOS:000310347900002 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
PubMed ID | 23005337 |
SCOPUSEID | 2-s2.0-84867942632 |
通讯作者地址 | [Zhou, Meng-Tao]Department of Surgery,First Affiliated Hospital,Wenzhou Medical College,96 Fuxue Lane,China |
Scopus学科分类 | Molecular Biology;Pulmonary and Respiratory Medicine;Clinical Biochemistry |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/3358 |
专题 | 附属第一医院 其他_附属义乌医院(义乌市中心医院) |
通讯作者 | Zhou, Meng-Tao |
作者单位 | 1.Department of Surgery,First Affiliated Hospital,Wenzhou Medical College,China; 2.Department of General Surgery,Affiliated Yiwu Hospital,Wenzhou Medical College,China; 3.Department of Multi-Disease Management,Traditional Chinese Medicine Hospital,Zhejiang University,China; 4.Second Affiliated Hospital,Zhejiang University,China; 5.Department of Surgery,First Affiliated Hospital,Wenzhou Medical College,96 Fuxue Lane,China |
第一作者单位 | 附属第一医院; 附属义乌医院(义乌市中心医院) |
通讯作者单位 | 附属第一医院 |
第一作者的第一单位 | 附属第一医院 |
推荐引用方式 GB/T 7714 | Wang, Hou-Hong,Tang, A-Mao,Chen, Li,et al. Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats[J]. EXPERIMENTAL LUNG RESEARCH,2012,38(9-10):445-452. |
APA | Wang, Hou-Hong, Tang, A-Mao, Chen, Li, & Zhou, Meng-Tao. (2012). Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats. EXPERIMENTAL LUNG RESEARCH, 38(9-10), 445-452. |
MLA | Wang, Hou-Hong,et al."Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats".EXPERIMENTAL LUNG RESEARCH 38.9-10(2012):445-452. |
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