Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats

doi:10.3109/01902148.2012.721860

科研成果详情

题名	Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats
作者	Wang, Hou-Hong1,2; Tang, A-Mao 3; Chen, Li 4; Zhou, Meng-Tao5
发表日期	2012-11
发表期刊	EXPERIMENTAL LUNG RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	animal model neutrophil elastase inhibitor ONO-5046 pulmonary injury rats
其他关键词	NEUTROPHIL ELASTASE INHIBITOR ; ACUTE NECROTIZING PANCREATITIS ; MICE ; ONO-5046 ; MODELS ; SODIUM ; DUCT
摘要	The incidence of acute pancreatitis has been rising worldwide in the past few decades. Despite extensive research efforts, the population-based mortality from acute pancreatitis remains high. Since dysfunction of multiple vital organs, most importantly the lungs, is the major cause of early death in acute pancreatitis patients, developing effective strategies to manage lung injury has become one of the focuses of recent research efforts aiming at improving the outcome of patients with acute pancreatitis. In this study, we attempted to create a rat model of acute pancreatitis through intraductal infusion of taurocholate and to evaluate the potential of sivelestat, a synthetic neutrophil elastase inhibitor, in protection against acute pancreatitis-associated lung injury using this rat model. The results demonstrated that: (1) 5% sodium taurocholate successfully induced histopathologic and biochemical abnormalities in the circulation, lung and pancreas characteristic of human acute pancreatitis, including an increase in amylase concentration and a decrease in partial arterial oxygen pressure (PaO2) in the blood, increases in activities of myeloperoxidase (MPO) (a lung injury marker) and neutrophil elastase (a quantitative indicator of neutrophil infiltration), and levels of malondialdehyde (an indicator of lipid peroxidation) and tumor necrosis factor-alpha (a major inflammatory mediator) in the lung; (2) intravenous administration of sivelestat effectively attenuated the taurocholate-induced abnormalities in all parameters analyzed except for serum amylase concentration. Our findings have validated the taurocholate model of acute pancreatitis and demonstrated great therapeutic potential for sivelestat in managing acute pancreatitis-associated lung injury.
出版者	INFORMA HEALTHCARE
出版地	LONDON
ISSN	0190-2148
EISSN	1521-0499
卷号	38 期号:9-10 页码:445-452
DOI	10.3109/01902148.2012.721860
页数	8
WOS类目	Respiratory System
WOS研究方向	Respiratory System
WOS记录号	WOS:000310347900002
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	23005337
SCOPUSEID	2-s2.0-84867942632
通讯作者地址	[Zhou, Meng-Tao]Department of Surgery,First Affiliated Hospital,Wenzhou Medical College,96 Fuxue Lane,China
Scopus学科分类	Molecular Biology;Pulmonary and Respiratory Medicine;Clinical Biochemistry
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/3358
专题	附属第一医院其他_附属义乌医院（义乌市中心医院）
通讯作者	Zhou, Meng-Tao
作者单位	1.Department of Surgery,First Affiliated Hospital,Wenzhou Medical College,China; 2.Department of General Surgery,Affiliated Yiwu Hospital,Wenzhou Medical College,China; 3.Department of Multi-Disease Management,Traditional Chinese Medicine Hospital,Zhejiang University,China; 4.Second Affiliated Hospital,Zhejiang University,China; 5.Department of Surgery,First Affiliated Hospital,Wenzhou Medical College,96 Fuxue Lane,China
第一作者单位	附属第一医院; 附属义乌医院（义乌市中心医院）
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Wang, Hou-Hong,Tang, A-Mao,Chen, Li,et al. Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats[J]. EXPERIMENTAL LUNG RESEARCH,2012,38(9-10):445-452.
APA	Wang, Hou-Hong, Tang, A-Mao, Chen, Li, & Zhou, Meng-Tao. (2012). Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats. EXPERIMENTAL LUNG RESEARCH, 38(9-10), 445-452.
MLA	Wang, Hou-Hong,et al."Potential of sivelestat in protection against severe acute pancreatitis-associated lung injury in rats".EXPERIMENTAL LUNG RESEARCH 38.9-10(2012):445-452.