Mesenchymal Stem Cells in Fibrotic Disease

doi:10.1016/j.stem.2017.07.011

科研成果详情

题名	Mesenchymal Stem Cells in Fibrotic Disease
作者	Elie El Agha 1; Rafael Kramann 2; Rebekka K Schneider 3; Xiaokun Li4; Werner Seeger 5; Benjamin D Humphreys 6; Saverio Bellusci7
发表期刊	Cell stem cell 影响因子和分区
语种	英语
原始文献类型	Review
关键词	lineage tracing mesenchymal stem cells organ fibrosis.
摘要	Fibrosis is associated with organ failure and high mortality and is commonly characterized by aberrant myofibroblast accumulation. Investigating the cellular origin of myofibroblasts in various diseases is thus a promising strategy for developing targeted anti-fibrotic treatments. Recent studies using genetic lineage tracing technology have implicated diverse organ-resident perivascular mesenchymal stem cell (MSC)-like cells and bone marrow-MSCs in myofibroblast generation during fibrosis development. In this Review, we give an overview of the emerging role of MSCs and MSC-like cells in myofibroblast-mediated fibrotic disease in the kidney, lung, heart, liver, skin, and bone marrow.
资助项目	National Institutes of Health[HL107307];
ISSN	1875-9777
EISSN	1875-9777
卷号	21 期号:2 页码:166-177.
DOI	10.1016/j.stem.2017.07.011
收录类别	PUBMED ; SCOPUS
发表日期	2017-08-03
URL	查看原文
Pubmed记录号	28777943
Scopus记录号	2-s2.0-85030481526
引用统计	被引频次：218[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/33501
专题	检验医学院（生命科学学院、生物学实验教学中心）
作者单位	1.Institute of Life Sciences, Wenzhou University, Wenzhou University-Wenzhou Medical University Collaborative Innovation Center of Biomedicine, Wenzhou, Zhejiang, China; Excellence Cluster Cardio-Pulmonary System (ECCPS), Universities of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-University Giessen, German Center for Lung Research (DZL), Giessen, Germany. Electronic address: elie.el-agha@innere.med.uni-giessen.de.; 2.Division of Nephrology and Clinical Immunology, Medical Faculty RWTH Aachen University, RWTH Aachen University, Aachen, Germany.; 3.Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, RWTH Aachen University, Aachen, Germany.; 4.Institute of Life Sciences, Wenzhou University, Wenzhou University-Wenzhou Medical University Collaborative Innovation Center of Biomedicine, Wenzhou, Zhejiang, China.; 5.Excellence Cluster Cardio-Pulmonary System (ECCPS), Universities of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-University Giessen, German Center for Lung Research (DZL), Giessen, Germany; Max Planck Institute for Heart and Lung Research, W.G. Kerckhoff Institute, Bad Nauheim, Germany.; 6.Division of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, USA.; 7.Institute of Life Sciences, Wenzhou University, Wenzhou University-Wenzhou Medical University Collaborative Innovation Center of Biomedicine, Wenzhou, Zhejiang, China; Excellence Cluster Cardio-Pulmonary System (ECCPS), Universities of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig-University Giessen, German Center for Lung Research (DZL), Giessen, Germany. Electronic address: saverio.bellusci@innere.med.uni-giessen.de.
第一作者单位	检验医学院（生命科学学院、生物学实验教学中心）
第一作者的第一单位	检验医学院（生命科学学院、生物学实验教学中心）
推荐引用方式 GB/T 7714	Elie El Agha,Rafael Kramann,Rebekka K Schneider,et al. Mesenchymal Stem Cells in Fibrotic Disease[J]. Cell stem cell,2017,21(2):166-177..
APA	Elie El Agha., Rafael Kramann., Rebekka K Schneider., Xiaokun Li., Werner Seeger., ... & Saverio Bellusci. (2017). Mesenchymal Stem Cells in Fibrotic Disease. Cell stem cell, 21(2), 166-177..
MLA	Elie El Agha,et al."Mesenchymal Stem Cells in Fibrotic Disease".Cell stem cell 21.2(2017):166-177..