The dynamics of murine mammary stem/progenitor cells

doi:10.1007/s11515-014-1308-0

科研成果详情

题名	The dynamics of murine mammary stem/progenitor cells
作者	Dong, Qiaoxiang1,2; Sun, Lu-Zhe 1,3
发表日期	2014-06-01
发表期刊	Frontiers in biology 影响因子和分区
语种	英语
原始文献类型	Review
关键词	cell hierarchy mammary stem cell.
摘要	The stem/progenitor cells in the murine mammary gland are a highly dynamic population of cells that are responsible for ductal elongation in puberty, homeostasis maintenance in adult, and lobulo-alveolar genesis during pregnancy. In recent years understanding the epithelial cell hierarchy within the mammary gland is becoming particularly important as these different stem/progenitor cells were perceived to be the cells of origin for various subtypes of breast cancer. Although significant advances have been made in enrichment and isolation of stem/progenitor cells by combinations of antibodies against cell surface proteins together with flow cytometry, and in identification of stem/progenitor cells with multi-lineage differentiation and self-renewal using mammary fat pad reconstitution assay and in vivo genetic labeling technique, a clear understanding of how these different stem/progenitors are orchestrated in the mammary gland is still lacking. Here we discuss the different in vivo and in vitro methods currently available for stem/progenitor identification, their associated caveats, and a possible new hierarchy model to reconcile various putative stem/progenitor cell populations identified by different research groups.
资助项目	National Institutes of Health[R01ES022057];
出版者	Higher Education Press
ISSN	1674-7984
EISSN	1674-7992
卷号	9 期号:3 页码:175-185.
DOI	10.1007/s11515-014-1308-0
收录类别	PUBMED ; SCOPUS ; CSCD
URL	查看原文
CSCD记录号	CSCD:5165869
PubMed ID	25580105
PMC记录号	PMC4286328
SCOPUSEID	2-s2.0-84939872612
通讯作者地址	[Dong, Qiaoxiang]Department of Cellular & Structural Biology, University of Texas Health Science Center,San Antonio,78299,United States
Scopus学科分类	Biotechnology;Ecology, Evolution, Behavior and Systematics;Ecology;Genetics
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/33180
专题	公共卫生学院_环境安全与健康风险评估研究院
通讯作者	Dong, Qiaoxiang
作者单位	1.Department of Cellular & Structural Biology, University of Texas Health Science Center,San Antonio,78299,United States; 2.Institute of Environmental Safety and Human Health, Wenzhou Medical University, University Town,Wenzhou,325035,China; 3.Cancer Therapy and Research Center, University of Texas Health Science Center,San Antonio,78299,United States
第一作者单位	公共卫生学院_环境安全与健康风险评估研究院
推荐引用方式 GB/T 7714	Dong, Qiaoxiang,Sun, Lu-Zhe. The dynamics of murine mammary stem/progenitor cells[J]. Frontiers in biology,2014,9(3):175-185..
APA	Dong, Qiaoxiang, & Sun, Lu-Zhe. (2014). The dynamics of murine mammary stem/progenitor cells. Frontiers in biology, 9(3), 175-185..
MLA	Dong, Qiaoxiang,et al."The dynamics of murine mammary stem/progenitor cells".Frontiers in biology 9.3(2014):175-185..