Green Tea Polyphenols Alleviate Autophagy Inhibition Induced by High Glucose in Endothelial Cells

doi:10.3967/bes2016.069

科研成果详情

名称	Green Tea Polyphenols Alleviate Autophagy Inhibition Induced by High Glucose in Endothelial Cells
作者	Zhang Pi Wei 1; Tian Chong 2; Xu Fang Yi 1; Chen Zhuo 1; Burnside, Raynard 1; Yi Wei Jie 1; Xiang Si Yun 1; Xie Xiao 1; Wu Nan Nan 1; Yang Hui 3; Zhao Na Na 4; Ye Xiao Lei 4; Ying Chen Jiang 1,5,6
发表期刊	BIOMEDICAL AND ENVIRONMENTAL SCIENCES
语种	英语
原始文献类型	Letter
其他关键词	PATHWAY ; HEART ; EGCG
摘要	Bovine aortic endothelial cells (BAECs) were cultured with high glucose (33 mmol/L), 4 mg/L green tea polyphenols (GTPs) or 4 mg/L GTPs co-treatment with high glucose for 24 h in the presence or absence of Bafilomycin-A1 (BAF). We observed that high glucose increased the accumulation of LC3-II. Treatment with BAF did not further increase the accumulation of LC3-II. Results also showed an increased level of p62 and decreased Beclin-1. However, GTPs showed inversed trends of those proteins. Furthermore, GTPs co-treatment with high glucose decreased the level of LC3-II and a much higher accumulation of LC3-II was observed in the presence of BAF in comparison with high glucose alone. Results also showed a decreased p62 and increased Beclin-1. The results demonstrated that GTPs alleviated autophagy inhibition induced by high glucose, which may be involved in the endothelial protective effects of green tea against hyperglycemia.
出版者	CHINESE CENTER DISEASE CONTROL & PREVENTION
出版地	BEIJING
ISSN	0895-3988
卷号	29
期号	7
页码	524-528
DOI	10.3967/bes2016.069
页数	5
WOS类目	Environmental Sciences ; Public, Environmental & Occupational Health
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
WOS记录号	WOS:000386544700008
收录类别	SCIE ; SCOPUS
发布日期	2016-07
URL	查看原文
PubMed ID	27554123
通讯作者地址	[YING, Chen Jiang]Key Laboratory of Environment and Health,Ministry of Education & Ministry of Environmental Protection,State Key Laboratory of Environmental Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,China
Scopus学科分类	Public Health, Environmental and Occupational Health;Health, Toxicology and Mutagenesis
SCOPUSEID	2-s2.0-85019429675
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/32263
专题	仁济学院_环境与公共卫生学部
通讯作者	Ying Chen Jiang
作者单位	1.Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Nutr & Food Hyg, Wuhan 430030, Hubei, Peoples R China; 2.Huazhong Univ Sci & Technol, Sch Nursing, Wuhan 430030, Hubei, Peoples R China; 3.Kecheng Peoples Hosp, Quzhou 324000, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Sch Environm Sci & Publ Hlth, Wenzhou 325000, Zhejiang, Peoples R China; 5.Huazhong Univ Sci & Technol, Minist Educ, Key Lab Environm & Hlth, Wuhan 430030, Hubei, Peoples R China; 6.Huazhong Univ Sci & Technol, Minist Environm Protect, State Key Lab Environm Hlth, Sch Publ Hlth,Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Zhang Pi Wei,Tian Chong,Xu Fang Yi,et al. Green Tea Polyphenols Alleviate Autophagy Inhibition Induced by High Glucose in Endothelial Cells. 2016.