The effect of age, sex and strains on the performance and outcome in animal models of stroke

doi:10.1016/j.neuint.2018.10.005

科研成果详情

题名	The effect of age, sex and strains on the performance and outcome in animal models of stroke
作者	Zhang, Hongxia 1; Lin, Siyang 2; Chen, Xudong 2; Gu, Lei2; Zhu, Xiaohong2; Zhang, Yinuo 2; Reyes, Kassandra 1; Wang, Brian 1; Jin, Kunlin1,2
发表日期	2019-07
发表期刊	NEUROCHEMISTRY INTERNATIONAL 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Aging Ischemia stroke Lifespan Risk factors Preclinical study
其他关键词	MIDDLE CEREBRAL-ARTERY ; ACUTE ISCHEMIC-STROKE ; HORMONE REPLACEMENT THERAPY ; CENTRAL-NERVOUS-SYSTEM ; NONHUMAN PRIMATE MODELS ; OXIDATIVE DAMAGE ; WHITE-MATTER ; MEMORY PERFORMANCE ; CEREBROVASCULAR ANATOMY ; PRECLINICAL MODELS
摘要	Stroke is one of the leading causes of death worldwide, and the majority of cerebral stroke is caused by occlusion of cerebral circulation, which eventually leads to brain infarction. Although stroke occurs mainly in the aged population, most animal models for experimental stroke in vivo almost universally rely on young-adult rodents for the evaluation of neuropathological, neurological, or behavioral outcomes after stroke due to their greater availability, lower cost, and fewer health problems. However, it is well established that aged animals differ from young animals in terms of physiology, neurochemistry, and behavior. Stroke-induced changes are more pronounced with advancing age. Therefore, the overlooked role of age in animal models of stroke could have an impact on data quality and hinder the translation of rodent models to humans. In addition to aging, other factors also influence functional performance after ischemic stroke. In this article, we summarize the differences between young and aged animals, the impact of age, sex and animal strains on performance and outcome in animal models of stroke and emphasize age as a key factor in preclinical stroke studies.
资助项目	American Heart Association Predoctoral Fellowship (USA)American Heart Association [18PRE34020126]
出版者	PERGAMON-ELSEVIER SCIENCE LTD
出版地	OXFORD
ISSN	0197-0186
EISSN	1872-9754
卷号	127 页码:2-11
DOI	10.1016/j.neuint.2018.10.005
页数	10
WOS类目	Biochemistry & Molecular Biology ; Neurosciences
WOS研究方向	Biochemistry & Molecular Biology ; Neurosciences & Neurology
WOS记录号	WOS:000474327500002
收录类别	SSCI ; SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	30291954
SCOPUSEID	2-s2.0-85054422301
通讯作者地址	[Jin, Kunlin]Department of Pharmacology and Neuroscience,University of North Texas Health Science Center,Fort Worth,76107,United States
Scopus学科分类	Cellular and Molecular Neuroscience;Cell Biology
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/3008
专题	第一临床医学院（信息与工程学院）、附属第一医院附属第一医院
通讯作者	Jin, Kunlin
作者单位	1.Department of Pharmacology and Neuroscience,University of North Texas Health Science Center,Fort Worth,76107,United States; 2.Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research,The First Affiliated Hospital,Wenzhou Medical University,Wenzhou,325000,China
推荐引用方式 GB/T 7714	Zhang, Hongxia,Lin, Siyang,Chen, Xudong,et al. The effect of age, sex and strains on the performance and outcome in animal models of stroke[J]. NEUROCHEMISTRY INTERNATIONAL,2019,127:2-11.
APA	Zhang, Hongxia., Lin, Siyang., Chen, Xudong., Gu, Lei., Zhu, Xiaohong., ... & Jin, Kunlin. (2019). The effect of age, sex and strains on the performance and outcome in animal models of stroke. NEUROCHEMISTRY INTERNATIONAL, 127, 2-11.
MLA	Zhang, Hongxia,et al."The effect of age, sex and strains on the performance and outcome in animal models of stroke".NEUROCHEMISTRY INTERNATIONAL 127(2019):2-11.