TCF4 gene polymorphism is associated with cognition in patients with schizophrenia and healthy controls

doi:10.1016/j.jpsychires.2015.07.022

科研成果详情

题名	TCF4 gene polymorphism is associated with cognition in patients with schizophrenia and healthy controls
作者	Hui, Li 1; Rao, Wen-Wang 2; Yu, Qiong 2; Kou, Changgui 2; Wu, Jing Qin 3,4; He, Jin Cai 5; Ye, Min Jie 1; Liu, Jia Hong 1; Xu, Xiao Jun 1; Zheng, Ke 1; Ruan, Li Na 1; Liu, Hong Yang 1; Hu, Wei Ming 1; Shao, Tian Nan 5; AngRabanes, Michael B.6; Soares, Jair C.6; Zhang, Xiang Yang 4,6
发表日期	2015-10
发表期刊	JOURNAL OF PSYCHIATRIC RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Schizophrenia TCF4 Cognition Association Genotype
其他关键词	CORTICAL GRAY-MATTER ; MENTAL-RETARDATION ; REPEATABLE BATTERY ; TWINS DISCORDANT ; CONFERRING RISK ; COMMON VARIANTS ; PERFORMANCE ; MEMORY ; HERITABILITY ; EXPRESSION
摘要	Background: Cognitive deficits have been identified as an important core feature of schizophrenia. Single nucleotide polymorphisms in the transcription factor 4 (TCF4) gene have been reported to be involved in the susceptibility to schizophrenia and be significantly related to cognitive deficits of schizophrenia and controls. This study examines whether the TCF4 rs2958182 polymorphism influences cognitive functions in chronic schizophrenia and controls. Methods: The presence of the TCF4 rs2958182 was determined in 976 patients and 420 controls using a case control design. We assessed all the patients' psychopathology using the Positive and Negative Syndrome Scale (PANSS). Cognition was assessed in 777 patients and 399 controls by using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Results: There were marginally significant differences in the TCF4 rs2958182 allelic and genotypic distributions between patients and controls (chi(2) = 3.48, p = 0.062 and chi(2) = 0.036, p = 0.036, respectively). Cognitive test scores were significantly lower in patients than in controls on all scales (all p < 0.001) except for the visuospatial/constructional index (p > 0.05). There were significant genotype effects on delayed memory score (p = 0.013), the RBANS total score (p = 0.028) and language score (p = 0.034). Further analysis showed that the language score significantly differed according to the genotypic groups (A/A+T/A group versus T/T group) (p = 0.007) in patients but not in controls (p > 0.05), and the delayed memory score also significantly differed according to the genotypic groups (A/A+T/A group versus T/T group) (p = 0.021) in controls but not in patients (p > 0.05). Conclusions: This study found that the A allele of the TCF4 rs2958182 polymorphism was the risk allele of schizophrenia, and was associated with lower cognitive performance in language in schizophrenia and delayed memory in controls. In contrast, the T allele of this polymorphism was found to be the schizophrenia risk allele in another study in Han Chinese people. (C) 2015 Elsevier Ltd. All rights reserved.
资助项目	Sci-Tech Planning Project of Medicine and Health of Zhejiang Province [2015KYB368]; Wenzhou Municipal Sci-Tech Bureau Program [Y20140478]; Sci-Res Project of Medicine and Health of Wenzhou Municipal [2015B21]; Beijing Municipal Natural Science FoundationBeijing Natural Science Foundation [7132063]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81371477]; NARSAD Independent Investigator GrantNARSAD [20314]; NHMRCNational Health and Medical Research Council of Australia [GNT1016870]
出版者	PERGAMON-ELSEVIER SCIENCE LTD
出版地	OXFORD
ISSN	0022-3956
EISSN	1879-1379
卷号	69 页码:95-101
DOI	10.1016/j.jpsychires.2015.07.022
页数	7
WOS类目	Psychiatry
WOS研究方向	Psychiatry
WOS记录号	WOS:000361927800015
收录类别	SSCI ; SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	26343600
SCOPUSEID	2-s2.0-84940831020
社科自定义期刊分类	D类
通讯作者地址	[Zhang, Xiang Yang]Biological Psychiatry Center,Beijing Hui-Long-Guan Hospital,Peking University,Chang-Ping District, Beijing,100096,China
Scopus学科分类	Psychiatry and Mental Health;Biological Psychiatry
TOP期刊	TOP期刊
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2938
专题	温州医科大学
通讯作者	Zhang, Xiang Yang
作者单位	1.Institute of Wenzhou Kangning Mental Health,Wenzhou Kangning Hospital,Wenzhou Medical University,Wenzhou, Zhejiang,China; 2.Department of Epidemiology and Biostatistics,School of Public Health,Jilin University,Changchun,China; 3.School of Biomedical Sciences and Pharmacy,Faculty of Health,The University of Newcastle,University Drive,Callaghan,2308,Australia; 4.Biological Psychiatry Center,Beijing HuiLongGuan Hospital,Peking University,Beijing,China; 5.Department of Neurology,The First Affiliated of Wenzhou Medical University,Wenzhou, Zhejiang,China; 6.Department of Psychiatry and Behavioral Sciences,Harris County Psychiatric Center,The University of Texas Health Science Center at Houston,Houston,United States
第一作者单位	温州医科大学
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Hui, Li,Rao, Wen-Wang,Yu, Qiong,et al. TCF4 gene polymorphism is associated with cognition in patients with schizophrenia and healthy controls[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2015,69:95-101.
APA	Hui, Li., Rao, Wen-Wang., Yu, Qiong., Kou, Changgui., Wu, Jing Qin., ... & Zhang, Xiang Yang. (2015). TCF4 gene polymorphism is associated with cognition in patients with schizophrenia and healthy controls. JOURNAL OF PSYCHIATRIC RESEARCH, 69, 95-101.
MLA	Hui, Li,et al."TCF4 gene polymorphism is associated with cognition in patients with schizophrenia and healthy controls".JOURNAL OF PSYCHIATRIC RESEARCH 69(2015):95-101.