科研成果详情

题名Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid
作者
发表日期2020
发表期刊NATURE AND SCIENCE OF SLEEP   影响因子和分区
语种英语
原始文献类型Article
关键词sleep cigarette smoking dopamine cerebrospinal fluid
其他关键词SEROTONIN-DOPAMINE INTERACTION ; NICOTINE EXPOSURE ; QUALITY INDEX ; TOBACCO ; BRAIN ; INSTRUMENT ; MODULATION ; RELEASE ; AROUSAL ; SMOKERS
摘要Background: Cigarette smoking has shown to be associated with sleep disturbance, especially prolonged sleep onset latency (SOL). Cigarette smoking stimulates the release of dopamine (DA) and serotonin (5-HT), which might promote awakening and inhibit rapid eye movement sleep. Dopamine transporter (DAT) and serotonin transporter play a key role in the reuptake of DA and 5-HT from the synaptic cleft into presynaptic neurons. However, the relationship among cigarette smoking, sleep disturbance and neurotransmitters has never been investigated in human cerebrospinal fluid (CSF). Methods: A total of 159 Chinese male subjects (81 active smokers and 78 non-smokers) who would undergo lumbar puncture before the surgery of anterior cruciate ligament reconstruction were recruited and 5mL-CSF samples were collected incidentally. CSF levels of DA, DAT, 5-HT, and serotonin transporter were measured using radioimmunoassay and ELISA. Sociodemographic data and the Pittsburgh Sleep Quality Index (PSQI) scale were collected before surgery. Results: PSQI global scores, SOL, and CSF DA levels were significantly higher in active smokers compared to non-smokers (2.00 [1.00-4.75] scores vs 4.00 [3.00-6.00] scores, p = 0.001; 10.00 [5.00-15.00] minutes vs 15.00 [10.00-30.00] minutes, p = 0.002; 87.20 [82.31-96.06]ng/mL vs 107.45 [92.78-114.38] ng/mL,p < 0.001), while CSF DAT levels were significantly lower in active smokers (0.35 [0.31-0.39] ng/mL vs 0.29 [0.26-0.34] ng/mL,p < 0.001). Conclusion: Cigarette smoking was indeed associated with sleep disturbance, shown by prolonged SOL, higher DA levels and lower DAT levels in CSF of active smokers.
资助项目Technology Support Project of Xinjiang [2017E0267]; Natural Science Foundation of Xinjiang Province [2018D01C228, 2018D01C239]; Youth Science and Technology Talents of Xinjiang [2017Q007]; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81421004]; 10th Inner Mongolia Grassland Talents Project, Beijing Natural Science Foundation [7152074]; Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences
出版者DOVE MEDICAL PRESS LTD
出版地ALBANY
ISSN1179-1608
卷号12页码:801-808
DOI10.2147/NSS.S272883
页数8
WOS类目Clinical Neurology ; Neurosciences
WOS研究方向Neurosciences & Neurology
WOS记录号WOS:000582356500001
收录类别SSCI ; SCIE ; SCOPUS ; PUBMED
URL查看原文
PubMed ID33122957
SCOPUSEID2-s2.0-85093917961
通讯作者地址[Wang, Fan]Xinjiang Key Laboratory of Neurological Disorder Research,The Second Affiliated Hospital,Xinjiang Medical University,Urumqi,830063,China ; [Wang, Fan]Psychosomatic Medicine Research Division,Inner Mongolia Medical University,Huhhot,010110,China ; [Wang, Fan]Beijing Hui-Long-Guan Hospital,Peking University,Beijing,100096,China
Scopus学科分类Applied Psychology;Behavioral Neuroscience
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/2921
专题药学院(分析测试中心)
精神医学学院
其他_附属康宁医院(温州市康宁医院)
其他_附属温岭医院(温岭市第一人民医院)
通讯作者Wang, Fan
作者单位
1.Department of Biomedical Engineering,College of Engineering,Peking University,Beijing,100871,China;
2.Xinjiang Key Laboratory of Neurological Disorder Research,The Second Affiliated Hospital,Xinjiang Medical University,Urumqi,830063,China;
3.Psychosomatic Medicine Research Division,Inner Mongolia Medical University,Huhhot,010110,China;
4.Zhuji Institute of Biomedicine,School of Pharmaceutical Sciences,Wenzhou Medical University,Shaoxing,311800,China;
5.School of Mental Health,Wenzhou Medical University,Wenzhou,325035,China;
6.The Affiliated Kangning Hospital,Wenzhou Medical University,Wenzhou,325035,China;
7.Department of Neurology,Inner Mongolia North Heavy Industries Group Corp. Ltd Hospital,Baotou,014030,China;
8.Beijing Jishuitan Hospital,Beijing,100035,China;
9.The Affiliated Wenling Hospital of Wenzhou Medical University,Wenling,317500,China;
10.An-Nan Hospital,China Medical University,Tainan,Taiwan;
11.College of Medicine,China Medical University,Taichung,Taiwan;
12.Beijing Hui-Long-Guan Hospital,Peking University,Beijing,100096,China
推荐引用方式
GB/T 7714
Li, Hui,Liu, Yanlong,Xing, Lifei,et al. Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid[J]. NATURE AND SCIENCE OF SLEEP,2020,12:801-808.
APA Li, Hui., Liu, Yanlong., Xing, Lifei., Yang, Xiaoyu., Xu, Jinzhong., ... & Wang, Fan. (2020). Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid. NATURE AND SCIENCE OF SLEEP, 12, 801-808.
MLA Li, Hui,et al."Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid".NATURE AND SCIENCE OF SLEEP 12(2020):801-808.

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