Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid

doi:10.2147/NSS.S272883

科研成果详情

题名	Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid
作者	Li, Hui 1,2,3; Liu, Yanlong4,5,6; Xing, Lifei 7; Yang, Xiaoyu 8; Xu, Jinzhong 9; Ren, Qiushi 1; Su, Kuan-Pin 4,10,11; Lu, Yanye 1; Wang, Fan 2,3,12
发表日期	2020
发表期刊	NATURE AND SCIENCE OF SLEEP 影响因子和分区
语种	英语
原始文献类型	Article
关键词	sleep cigarette smoking dopamine cerebrospinal fluid
其他关键词	SEROTONIN-DOPAMINE INTERACTION ; NICOTINE EXPOSURE ; QUALITY INDEX ; TOBACCO ; BRAIN ; INSTRUMENT ; MODULATION ; RELEASE ; AROUSAL ; SMOKERS
摘要	Background: Cigarette smoking has shown to be associated with sleep disturbance, especially prolonged sleep onset latency (SOL). Cigarette smoking stimulates the release of dopamine (DA) and serotonin (5-HT), which might promote awakening and inhibit rapid eye movement sleep. Dopamine transporter (DAT) and serotonin transporter play a key role in the reuptake of DA and 5-HT from the synaptic cleft into presynaptic neurons. However, the relationship among cigarette smoking, sleep disturbance and neurotransmitters has never been investigated in human cerebrospinal fluid (CSF). Methods: A total of 159 Chinese male subjects (81 active smokers and 78 non-smokers) who would undergo lumbar puncture before the surgery of anterior cruciate ligament reconstruction were recruited and 5mL-CSF samples were collected incidentally. CSF levels of DA, DAT, 5-HT, and serotonin transporter were measured using radioimmunoassay and ELISA. Sociodemographic data and the Pittsburgh Sleep Quality Index (PSQI) scale were collected before surgery. Results: PSQI global scores, SOL, and CSF DA levels were significantly higher in active smokers compared to non-smokers (2.00 [1.00-4.75] scores vs 4.00 [3.00-6.00] scores, p = 0.001; 10.00 [5.00-15.00] minutes vs 15.00 [10.00-30.00] minutes, p = 0.002; 87.20 [82.31-96.06]ng/mL vs 107.45 [92.78-114.38] ng/mL,p < 0.001), while CSF DAT levels were significantly lower in active smokers (0.35 [0.31-0.39] ng/mL vs 0.29 [0.26-0.34] ng/mL,p < 0.001). Conclusion: Cigarette smoking was indeed associated with sleep disturbance, shown by prolonged SOL, higher DA levels and lower DAT levels in CSF of active smokers.
资助项目	Technology Support Project of Xinjiang [2017E0267]; Natural Science Foundation of Xinjiang Province [2018D01C228, 2018D01C239]; Youth Science and Technology Talents of Xinjiang [2017Q007]; Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81421004]; 10th Inner Mongolia Grassland Talents Project, Beijing Natural Science Foundation [7152074]; Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences
出版者	DOVE MEDICAL PRESS LTD
出版地	ALBANY
ISSN	1179-1608
卷号	12 页码:801-808
DOI	10.2147/NSS.S272883
页数	8
WOS类目	Clinical Neurology ; Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000582356500001
收录类别	SSCI ; SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	33122957
SCOPUSEID	2-s2.0-85093917961
通讯作者地址	[Wang, Fan]Xinjiang Key Laboratory of Neurological Disorder Research,The Second Affiliated Hospital,Xinjiang Medical University,Urumqi,830063,China ; [Wang, Fan]Psychosomatic Medicine Research Division,Inner Mongolia Medical University,Huhhot,010110,China ; [Wang, Fan]Beijing Hui-Long-Guan Hospital,Peking University,Beijing,100096,China
Scopus学科分类	Applied Psychology;Behavioral Neuroscience
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2921
专题	药学院（分析测试中心）精神医学学院其他_附属康宁医院（温州市康宁医院）其他_附属温岭医院（温岭市第一人民医院）
通讯作者	Wang, Fan
作者单位	1.Department of Biomedical Engineering,College of Engineering,Peking University,Beijing,100871,China; 2.Xinjiang Key Laboratory of Neurological Disorder Research,The Second Affiliated Hospital,Xinjiang Medical University,Urumqi,830063,China; 3.Psychosomatic Medicine Research Division,Inner Mongolia Medical University,Huhhot,010110,China; 4.Zhuji Institute of Biomedicine,School of Pharmaceutical Sciences,Wenzhou Medical University,Shaoxing,311800,China; 5.School of Mental Health,Wenzhou Medical University,Wenzhou,325035,China; 6.The Affiliated Kangning Hospital,Wenzhou Medical University,Wenzhou,325035,China; 7.Department of Neurology,Inner Mongolia North Heavy Industries Group Corp. Ltd Hospital,Baotou,014030,China; 8.Beijing Jishuitan Hospital,Beijing,100035,China; 9.The Affiliated Wenling Hospital of Wenzhou Medical University,Wenling,317500,China; 10.An-Nan Hospital,China Medical University,Tainan,Taiwan; 11.College of Medicine,China Medical University,Taichung,Taiwan; 12.Beijing Hui-Long-Guan Hospital,Peking University,Beijing,100096,China
推荐引用方式 GB/T 7714	Li, Hui,Liu, Yanlong,Xing, Lifei,et al. Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid[J]. NATURE AND SCIENCE OF SLEEP,2020,12:801-808.
APA	Li, Hui., Liu, Yanlong., Xing, Lifei., Yang, Xiaoyu., Xu, Jinzhong., ... & Wang, Fan. (2020). Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid. NATURE AND SCIENCE OF SLEEP, 12, 801-808.
MLA	Li, Hui,et al."Association of Cigarette Smoking with Sleep Disturbance and Neurotransmitters in Cerebrospinal Fluid".NATURE AND SCIENCE OF SLEEP 12(2020):801-808.