Interleukin-10 level is associated with post-stroke depression in acute ischaemic stroke patients

doi:10.1016/j.jad.2021.06.037

科研成果详情

题名	Interleukin-10 level is associated with post-stroke depression in acute ischaemic stroke patients
作者	Chi, Chu-Huai 1; Huang, Yuan-Yuan2; Ye, Su-Zhen2; Shao, Meng-Meng2; Jiang, Ming-Xia 2; Yang, Meng-Yao 2; Wu, Qian2; Shao, Bei3; Li, Xian-Mei2
发表日期	2021-10-01
发表期刊	JOURNAL OF AFFECTIVE DISORDERS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Interleukin-10 Acute ischemic stroke Post-stroke depression Prognosis
其他关键词	INFLAMMATORY CYTOKINES ; METAANALYSIS ; PREDICTORS ; MECHANISMS ; INJURY ; IL-10
摘要	Background: Interleukin-10 (IL-10) is a pathophysiological factor in acute ischaemic stroke (AIS) and is relevant to mood disorders after stroke. We evaluated the predictive value of IL-10 in patients with post-stroke depression (PSD) Methods: A total of 350 stroke patients were recruited at baseline, and 151 AIS patients were screened and completed a 1-month follow-up. Serum IL-10 levels were measured within 24 h of admission. We used the 17 item Hamilton Depression Scale (HAMD-17) to evaluate depression symptoms; PSD was defined as an HAMD score >= 7. Results: Fifty-one (33.8%) patients showed a more serious stroke degree, larger infarction volume, and poorer daily life activities and prognosis (P < 0.05) and were diagnosed with PSD at the 1-month follow-up. Their IL-10 level decreased significantly compared to the non-PSD group (P < 0.001). After adjusting for confounders, IL-10 could be used as an independent predictor for PSD with an adjusted odds ratio (OR) of 0.615 (95% CI 0.410-0.923, P = 0.019). In addition, the optimal cut-off value of IL-10 was 0.615 pg/mL based on an area under the receiver operating characteristic curve of 0.692 (95% CI 0.604-0.781, P < 0.001), demonstrating that IL-10 could predict the occurrence of PSD. Moreover, IL-10 was an indicator of stroke severity, living ability, and functional outcomes (P < 0.05). Limitations: IL-10 was only measured upon admission; dynamic changes need to be further monitored. This was also a single-centre study with a relatively small sample . Conclusions: Lower IL-10 levels may be used to predict PSD.
资助项目	Healthcare Clinic of the First Affiliated Hospital of Wenzhou Medical University
出版者	ELSEVIER
出版地	AMSTERDAM
ISSN	0165-0327
EISSN	1573-2517
卷号	293 页码:254-260
DOI	10.1016/j.jad.2021.06.037
页数	7
WOS类目	Clinical Neurology ; Psychiatry
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS记录号	WOS:000685022800031
收录类别	SSCI ; SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	34217963
SCOPUSEID	2-s2.0-85109202615
社科自定义期刊分类	C类
通讯作者地址	[Li, Xian-Mei]Department of Rehabilitation,The First Affiliated Hospital of Wenzhou Medical University,Shangcai Road,Wenzhou,325000,China
Scopus学科分类	Clinical Psychology;Psychiatry and Mental Health
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2907
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院附属第一医院_康复科第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者	Li, Xian-Mei
作者单位	1.Department of Hepatobiliary Surgery,Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Rehabilitation,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Department of Neurology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Chi, Chu-Huai,Huang, Yuan-Yuan,Ye, Su-Zhen,et al. Interleukin-10 level is associated with post-stroke depression in acute ischaemic stroke patients[J]. JOURNAL OF AFFECTIVE DISORDERS,2021,293:254-260.
APA	Chi, Chu-Huai., Huang, Yuan-Yuan., Ye, Su-Zhen., Shao, Meng-Meng., Jiang, Ming-Xia., ... & Li, Xian-Mei. (2021). Interleukin-10 level is associated with post-stroke depression in acute ischaemic stroke patients. JOURNAL OF AFFECTIVE DISORDERS, 293, 254-260.
MLA	Chi, Chu-Huai,et al."Interleukin-10 level is associated with post-stroke depression in acute ischaemic stroke patients".JOURNAL OF AFFECTIVE DISORDERS 293(2021):254-260.