Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD

doi:10.1503/jpn.110180

科研成果详情

题名	Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD
作者	Liao, Yi 1; Huang, Xiaoqi 1; Wu, Qizhu 1; Yang, Chuang2; Kuang, Weihong 3; Du, Mingying 1; Lui, Su 1; Yue, Qiang 1; Chan, Raymond C. K.4,5; Kemp, Graham J.6,7; Gong, Qiyong 1
发表期刊	JOURNAL OF PSYCHIATRY & NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	LATE-LIFE DEPRESSION ; WHITE-MATTER ABNORMALITIES ; MICROSTRUCTURAL ABNORMALITIES ; MOOD DISORDERS ; BRAIN ; CIRCUITS ; HODOLOGY ; CONNECTIVITY ; ANISOTROPY ; UPDATE
摘要	Background: Many studies using diffusion tensor imaging (DTI) have demonstrated impaired white matter integrity in patients with major depressive disorder (MDD), with significant results found in diverse brain regions. We sought to identify whether there are consistent changes of regional white matter integrity in patients with MDD, as shown by decreased fractional anisotropy in DTI. Method: A systematic search strategy was used to identify relevant whole brain voxel-based DTI studies of patients with MDD in relation to comparison groups. Relevant databases were searched for studies published between January 1994 and February 2011 using combinations of the terms DTI or diffusion tensor; whole brain or voxel-based; and depress*. Using the studies that met our inclusion criteria, we performed a meta-analysis of the coordinates of decreased fractional anisotropy using the activation likelihood estimation (ALE) method, which detects 3-dimensional conjunctions of coordinates from multiple studies, weighted by sample size. We then used DTIquery software for fibre tracking to locate the fascicles involved in each region. Results: We included 11 studies with a combined sample of 231 patients with MDD and 261 comparison participants, providing 50 coordinates of decreased fractional anisotropy. Our meta-analysis identified 4 consistent locations of decreased fractional anisotropy in patients with MDD: white matter in the right frontal lobe, right fusiform gyrus, left frontal lobe and right occipital lobe. Fibre tracking showed that the main fascicles involved were the right inferior longitudinal fasciculus, right inferior fronto-occipital fasciculus, right posterior thalamic radiation and interhemispheric fibres running through the genu and body of the corpus callosum. Limitations: The number of studies included was relatively small, and the DTI data acquisition and analysis techniques were heterogeneous. The ALE method cannot handle studies with no significant group differences. Conclusion: Voxel-based analysis of DTI studies of patients with MDD consistently identified decreased fractional anisotropy in the white matter fascicles connecting the prefrontal cortex within cortical (frontal, temporal and occipital lobes) and subcortical areas (amygdala and hippocampus). This is strong evidence for the involvement of these neural circuits in the pathology of MDD.
资助项目	National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81171488, 81030027]; National Key Technologies R&D Program of ChinaNational Key Technology R&D Program [2012BAI01B03]
出版者	CMA-CANADIAN MEDICAL ASSOC
出版地	OTTAWA
ISSN	1180-4882
EISSN	1488-2434
卷号	38 期号:1 页码:49-56
DOI	10.1503/jpn.110180
页数	8
WOS类目	Neurosciences ; Psychiatry
WOS研究方向	Neurosciences & Neurology ; Psychiatry
WOS记录号	WOS:000318039600007
收录类别	SSCI ; SCIE ; SCOPUS
发表日期	2013-01
URL	查看原文
Scopus记录号	2-s2.0-84871566294
ESI高被引论文	2020-01 ; 2020-03 ; 2020-05 ; 2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-09 ; 2021-11 ; 2022-01 ; 2022-03 ; 2022-05 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03
社科自定义期刊分类	D类
引用统计	被引频次：265[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2846
专题	第一临床医学院（信息与工程学院）、附属第一医院_精神病与精神卫生学
通讯作者	Gong, Qiyong
作者单位	1.Sichuan Univ, West China Hosp, Dept Radiol, HMRRC, Chengdu 610041, Peoples R China; 2.Wenzhou Med Sch, Dept Psychiat, Wenzhou, Peoples R China; 3.Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Dept Psychiat, Chengdu 610064, Peoples R China; 4.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China; 5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China; 6.Univ Liverpool, MARIARC, Liverpool L69 3BX, Merseyside, England; 7.Univ Liverpool, Inst Ageing & Chron Dis, Liverpool L69 3BX, Merseyside, England
推荐引用方式 GB/T 7714	Liao, Yi,Huang, Xiaoqi,Wu, Qizhu,et al. Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD[J]. JOURNAL OF PSYCHIATRY & NEUROSCIENCE,2013,38(1):49-56.
APA	Liao, Yi., Huang, Xiaoqi., Wu, Qizhu., Yang, Chuang., Kuang, Weihong., ... & Gong, Qiyong. (2013). Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD. JOURNAL OF PSYCHIATRY & NEUROSCIENCE, 38(1), 49-56.
MLA	Liao, Yi,et al."Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD".JOURNAL OF PSYCHIATRY & NEUROSCIENCE 38.1(2013):49-56.