Effects of antidepressant medicines on preventing relapse of unipolar depression: a pooled analysis of parametric survival curves

doi:10.1017/S0033291720001610

科研成果详情

题名	Effects of antidepressant medicines on preventing relapse of unipolar depression: a pooled analysis of parametric survival curves
作者	Zhou, Dongdong 1; Lv, Zhen 1; Shi, Lei 1; Zhou, Xiaoxin 2; Lin, Qingxia3; Chen, Xiaorong 1; Wan, Liyang 1; Li, Yao 1; Ran, Liuyi 1; Huang, Yan 4; Wang, Gaomao 1; Li, Daqi 1; Wang, Wo 1; Liu, Chuan 1; Kuang, Li 1,5
发表日期	2022-01
发表期刊	PSYCHOLOGICAL MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Antidepressants major depressive disorder recurrence relapse
其他关键词	LONG-TERM TREATMENT ; DOUBLE-BLIND ; MAINTENANCE TREATMENT ; CONTINUATION TREATMENT ; PLACEBO-SUBSTITUTION ; RECURRENT DEPRESSION ; COGNITIVE THERAPY ; DISORDER ; EFFICACY ; VENLAFAXINE
摘要	Background Major depressive disorder is characterized by a high risk of relapse. We aimed to compare the prophylactic effects of different antidepressant medicines (ADMs). Methods PubMed, Cochrane Central Register of Controlled Trials, Embase and the Web of Science were searched on 4 July 2019. A pooled analysis of parametric survival curves was performed using a Bayesian framework. The main outcomes were hazard ratios (HRs), relapse-free survival and mean relapse-free months. Results Forty randomized controlled trials were included. The 1-year relapse-free survival for ADM (76%) was significantly better than that for placebo (56%). Most of the relapse difference (86.5%) occurred in the first 6 months. Most HRs were not constant over time. Proof of benefit after 6 months of follow-up was not established partially because of small differences between the drug and placebo after 6 months. Almost all studies used an 'enriched' randomized discontinuation design, which may explain the high relapse rates in the first 6 months after randomization. Conclusions The superiority of ADM v. placebo was mainly attributed to the difference in relapse rates that occurred in the first 6 months. Our analysis provided evidence that the prophylactic efficacy was not constant over time. A beneficial effect was observed, but the prevention of new episodes after 6 months was questionable. These findings may have implications for clinical practice.
出版者	CAMBRIDGE UNIV PRESS
出版地	NEW YORK
ISSN	0033-2917
EISSN	1469-8978
卷号	52 期号:1 页码:48-56
DOI	10.1017/S0033291720001610
页数	9
WOS类目	Psychology, Clinical ; Psychiatry ; Psychology
WOS研究方向	Psychology ; Psychiatry
WOS记录号	WOS:000733759000008
收录类别	SSCI ; SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	32501194
SCOPUSEID	2-s2.0-85086865639
ESI高被引论文	2022-05 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03
社科自定义期刊分类	A类
通讯作者地址	[Liu, Chuan]Mental Health Center,University-Town Hospital of Chongqing Medical University,Chongqing,China ; [Kuang, Li]Mental Health Center,University-Town Hospital of Chongqing Medical University,Chongqing,China
Scopus学科分类	Applied Psychology;Psychiatry and Mental Health
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2650
专题	精神医学学院_精神医学系附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_精神病与精神卫生学
通讯作者	Liu, Chuan; Kuang, Li
作者单位	1.Mental Health Center,University-Town Hospital of Chongqing Medical University,Chongqing,China; 2.Medical Department,University-Town Hospital of Chongqing Medical University,Chongqing,China; 3.Department of Psychiatry,Wenzhou Medical University,Zhejiang Province,China; 4.GCP Office,Chongqing Traditional Chinese Medicine Hospital,Chongqing,China; 5.Department of Psychiatry,Chongqing Medical University,Chongqing,China
推荐引用方式 GB/T 7714	Zhou, Dongdong,Lv, Zhen,Shi, Lei,et al. Effects of antidepressant medicines on preventing relapse of unipolar depression: a pooled analysis of parametric survival curves[J]. PSYCHOLOGICAL MEDICINE,2022,52(1):48-56.
APA	Zhou, Dongdong., Lv, Zhen., Shi, Lei., Zhou, Xiaoxin., Lin, Qingxia., ... & Kuang, Li. (2022). Effects of antidepressant medicines on preventing relapse of unipolar depression: a pooled analysis of parametric survival curves. PSYCHOLOGICAL MEDICINE, 52(1), 48-56.
MLA	Zhou, Dongdong,et al."Effects of antidepressant medicines on preventing relapse of unipolar depression: a pooled analysis of parametric survival curves".PSYCHOLOGICAL MEDICINE 52.1(2022):48-56.