科研成果详情

题名Effects of antidepressant medicines on preventing relapse of unipolar depression: a pooled analysis of parametric survival curves
作者
发表日期2022-01
发表期刊PSYCHOLOGICAL MEDICINE   影响因子和分区
语种英语
原始文献类型Article
关键词Antidepressants major depressive disorder recurrence relapse
其他关键词LONG-TERM TREATMENT ; DOUBLE-BLIND ; MAINTENANCE TREATMENT ; CONTINUATION TREATMENT ; PLACEBO-SUBSTITUTION ; RECURRENT DEPRESSION ; COGNITIVE THERAPY ; DISORDER ; EFFICACY ; VENLAFAXINE
摘要Background Major depressive disorder is characterized by a high risk of relapse. We aimed to compare the prophylactic effects of different antidepressant medicines (ADMs). Methods PubMed, Cochrane Central Register of Controlled Trials, Embase and the Web of Science were searched on 4 July 2019. A pooled analysis of parametric survival curves was performed using a Bayesian framework. The main outcomes were hazard ratios (HRs), relapse-free survival and mean relapse-free months. Results Forty randomized controlled trials were included. The 1-year relapse-free survival for ADM (76%) was significantly better than that for placebo (56%). Most of the relapse difference (86.5%) occurred in the first 6 months. Most HRs were not constant over time. Proof of benefit after 6 months of follow-up was not established partially because of small differences between the drug and placebo after 6 months. Almost all studies used an 'enriched' randomized discontinuation design, which may explain the high relapse rates in the first 6 months after randomization. Conclusions The superiority of ADM v. placebo was mainly attributed to the difference in relapse rates that occurred in the first 6 months. Our analysis provided evidence that the prophylactic efficacy was not constant over time. A beneficial effect was observed, but the prevention of new episodes after 6 months was questionable. These findings may have implications for clinical practice.
出版者CAMBRIDGE UNIV PRESS
出版地NEW YORK
ISSN0033-2917
EISSN1469-8978
卷号52期号:1页码:48-56
DOI10.1017/S0033291720001610
页数9
WOS类目Psychology, Clinical ; Psychiatry ; Psychology
WOS研究方向Psychology ; Psychiatry
WOS记录号WOS:000733759000008
收录类别SSCI ; SCIE ; PUBMED ; SCOPUS
URL查看原文
PubMed ID32501194
SCOPUSEID2-s2.0-85086865639
ESI高被引论文2022-05 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03
社科自定义期刊分类A类
通讯作者地址[Liu, Chuan]Mental Health Center,University-Town Hospital of Chongqing Medical University,Chongqing,China ; [Kuang, Li]Mental Health Center,University-Town Hospital of Chongqing Medical University,Chongqing,China
Scopus学科分类Applied Psychology;Psychiatry and Mental Health
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/2650
专题精神医学学院_精神医学系
附属第一医院
第一临床医学院(信息与工程学院)、附属第一医院_精神病与精神卫生学
通讯作者Liu, Chuan; Kuang, Li
作者单位
1.Mental Health Center,University-Town Hospital of Chongqing Medical University,Chongqing,China;
2.Medical Department,University-Town Hospital of Chongqing Medical University,Chongqing,China;
3.Department of Psychiatry,Wenzhou Medical University,Zhejiang Province,China;
4.GCP Office,Chongqing Traditional Chinese Medicine Hospital,Chongqing,China;
5.Department of Psychiatry,Chongqing Medical University,Chongqing,China
推荐引用方式
GB/T 7714
Zhou, Dongdong,Lv, Zhen,Shi, Lei,et al. Effects of antidepressant medicines on preventing relapse of unipolar depression: a pooled analysis of parametric survival curves[J]. PSYCHOLOGICAL MEDICINE,2022,52(1):48-56.
APA Zhou, Dongdong., Lv, Zhen., Shi, Lei., Zhou, Xiaoxin., Lin, Qingxia., ... & Kuang, Li. (2022). Effects of antidepressant medicines on preventing relapse of unipolar depression: a pooled analysis of parametric survival curves. PSYCHOLOGICAL MEDICINE, 52(1), 48-56.
MLA Zhou, Dongdong,et al."Effects of antidepressant medicines on preventing relapse of unipolar depression: a pooled analysis of parametric survival curves".PSYCHOLOGICAL MEDICINE 52.1(2022):48-56.

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