Pandemic 2009 influenza A (H1N1)-associated deaths among children in China: A retrospective analysis

doi:10.1002/ped4.12053

科研成果详情

题名	Pandemic 2009 influenza A (H1N1)-associated deaths among children in China: A retrospective analysis
作者	Lu, Zhiwei 1; Zheng, Yuejie 1; He, Yanxia 1; Chen, Huizhong 2; Wang, Heping 1; Cao, Ling 2; Zhao, Deyu 3; Ji, Wei 4; Shang, Yunxiao 5; Li, Changchong6; Chen, Zhimin 7; Zhao, Shunying 8; Nong, Guangmin 9; Chen, Qiang 10; Liu, Enmei 11; Wan, Chaomin 12; Wang, Ying 13; Yang, Tong 14; Wang, Zhenhua 15; Deng, Li 16; Lu, Quan 17
发表日期	2018-09-01
发表期刊	PEDIATRIC INVESTIGATION 影响因子和分区
语种	英语
原始文献类型	Article
关键词	2009 influenza A (H1N1) Mortality rates Children
摘要	ImportanceA cluster of influenza-associated deaths occurred among children during pandemic 2009 influenza A (H1N1) in China, but the risk factors and causes for death have not been clarified. ObjectiveWe describe the clinical findings regarding 2009 influenza A (H1N1)-associated pediatric deaths in China, including the risk factors for death. MethodsThe definition of 2009 influenza A (H1N1)-associated pediatric death is death in a child who is younger than 14 years and has laboratory-confirmed influenza. We collected data of total 810 hospitalized patients with 2009 influenza A (H1N1) infection from September 2009 to February 2010 in 17 hospitals across China. The clinical characteristics, laboratory abnormalities, and treatment course were retrospectively studied. ResultsOf the 810 patients hospitalized with 2009 influenza A (H1N1) infection, 19 (2.3%) died. Ten patients died from severe pneumonia and acute respiratory distress syndrome; eight died from encephalopathy/encephalitis; one died from secondary fungal meningitis. Patients who died were more likely than patients who survived to have neutrophilia, lymphopenia, elevated C-reactive protein, and elevations of lactate dehydrogenase, creatine kinase, creatine kinase-MB, aspartate aminotransferase and alanine aminotransferase. There were no significant differences in the median age, median time from onset of illness to admission, underlying chronic disease, and initiation of antiviral therapy within 48 hours of illness onset, between patients who died and those who survived. InterpretationThe risk factors for pediatric death associated with 2009 influenza A (H1N1) infection are different from those of seasonal influenza. The most common causes of death are viral pneumonia, acute respiratory distress syndrome, and encephalopathy/encephalitis.
出版者	WILEY
出版地	HOBOKEN
ISSN	2574-2272
EISSN	2574-2272
卷号	2 期号:3 页码:166-171
DOI	10.1002/ped4.12053
页数	6
WOS类目	Pediatrics
WOS研究方向	Pediatrics
WOS记录号	WOS:000659353400007
收录类别	ESCI ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	32851255
PMC记录号	PMC7331416
SCOPUSEID	2-s2.0-85099325924
通讯作者地址	[Zheng, Yuejie]Shenzhen Childrens Hosp, Dept Resp, Shenzhen 518026, Peoples R China.
Scopus学科分类	Pediatrics, Perinatology and Child Health
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2608
专题	第二临床医学院，附属第二医院、育英儿童医院_儿科学_儿内呼吸
通讯作者	Zheng, Yuejie
作者单位	1.Shenzhen Childrens Hosp, Dept Resp Med, Shenzhen, Guangdong, Peoples R China; 2.Capital Inst Pediat, Childrens Hosp, Dept Pulmonol, Beijing, Peoples R China; 3.Nanjing Med Univ, Childrens Hosp, Dept Respirat, Nanjing, Jiangsu, Peoples R China; 4.Soochow Univ, Childrens Hosp, Dept Resp, Suzhou, Jiangsu, Peoples R China; 5.China Med Univ, Shengjing Hosp, Dept Pediat Resp Med, Shenyang, Liaoning, Peoples R China; 6.Wenzhou Med Univ, Yuying Childrens Hosp, Dept Resp, Wenzhou, Zhejiang, Peoples R China; 7.Zhejiang Univ, Childrens Hosp, Dept Pulmonol, Sch Med, Hangzhou, Zhejiang, Peoples R China; 8.Capital Med Univ, Beijing Childrens Hosp, Dept Resp Med, Natl Ctr Childrens Hlth, Beijing, Peoples R China; 9.Guangxi Med Univ, Affiliated Hosp 1, Dept Pediat, Nanning, Guangxi, Peoples R China; 10.Jiangxi Prov Childrens Hosp, Dept Resp, Nanchang, Jiangxi, Peoples R China; 11.Chongqing Med Univ, Childrens Hosp Affiliated, Dept Resp, Chongqing, Peoples R China; 12.Sichuan Univ, West China Second Hosp, Dept Infect Dis, Chengdu, Sichuan, Peoples R China; 13.Guilin Peoples Hosp, Dept Pediat, Guilin, Guangxi, Peoples R China; 14.Liuzhou Gen Hosp, Dept Pediat, Liuzhou, Guangxi, Peoples R China; 15.Changchun Childrens Hosp, Dept Resp, Changchun, Jilin, Peoples R China; 16.Guangzhou Women & Childrens Med Ctr, Dept Resp, Guangzhou, Guangdong, Peoples R China; 17.Shanghai Jiao Tong Univ, Childrens Hosp, Dept Resp, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Lu, Zhiwei,Zheng, Yuejie,He, Yanxia,et al. Pandemic 2009 influenza A (H1N1)-associated deaths among children in China: A retrospective analysis[J]. PEDIATRIC INVESTIGATION,2018,2(3):166-171.
APA	Lu, Zhiwei., Zheng, Yuejie., He, Yanxia., Chen, Huizhong., Wang, Heping., ... & Lu, Quan. (2018). Pandemic 2009 influenza A (H1N1)-associated deaths among children in China: A retrospective analysis. PEDIATRIC INVESTIGATION, 2(3), 166-171.
MLA	Lu, Zhiwei,et al."Pandemic 2009 influenza A (H1N1)-associated deaths among children in China: A retrospective analysis".PEDIATRIC INVESTIGATION 2.3(2018):166-171.