Endoplasmic Reticulum Stress and Atherosclerosis

doi:10.2174/157340210790231744

科研成果详情

题名	Endoplasmic Reticulum Stress and Atherosclerosis
作者	Zhou, Huiping1,2,3; Sun, Lixin 1,2; Xiao, Jian 1,2,3; Zhang, Luyong 1,2; Li, Xiaokun1,2,3; Studer, Elaine 1,2; Pandak, William M.1,2; Hylemon, Phillip B.1,2
发表期刊	CURRENT HYPERTENSION REVIEWS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	ER stress the UPR atherosclerosis inflammation
摘要	The endoplasmic reticulum (ER) is the site of lipid and protein synthesis, protein folding and maturation, and storage of free calcium in eukaryotic cells. All proteins destined for the extracellular space, plasma membrane or other intracellular compartments are folded and assembled in the ER. Disruption of the ER homeostatic mechanisms, such as perturbations in intracellular calcium homeostasis, alteration of redox status and protein glycosylation, overloading of free cholesterol, or glucose deprivation, will induce accumulation of unfolded and misfolded proteins in the ER lumen. Mammalian cells respond to these perburbations by activating the ER stress response signaling pathway, called the unfolded protein response (UPR). This cellular stress pathway is designed to cope with various environmental perturbations and ensure that protein-folding capacity is not overwhelmed. The malfolded proteins are eliminated by ER-associated protein degradation (ERAD). However, prolonged activation of the UPR ultimately triggers cell apoptosis. Recent studies have demonstrated that ER stress-induced apoptosis plays a critical role in the pathogenesis of many diseases such as diabetes, neurodegenerative diseases, inflammation, liver disease, and cardiovascular disease. This review summarizes the recent understanding of ER stress signaling in the pathogenesis of atherosclerosis.
资助项目	National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 AI057189, R21 AI068432, R01 AT004148, P01 DK38030]; A.D. William foundation; GlaxoSmithKlineGlaxoSmithKline; Jeffress Memorial Trust; Wenzhou Medical College
出版者	BENTHAM SCIENCE PUBL LTD
出版地	SHARJAH
ISSN	1573-4021
EISSN	1875-6506
卷号	6 期号:1 页码:66-71
DOI	10.2174/157340210790231744
页数	6
WOS类目	Peripheral Vascular Disease
WOS研究方向	Cardiovascular System & Cardiology
WOS记录号	WOS:000434574900007
收录类别	ESCI ; SCOPUS
发表日期	2022-10-20
URL	查看原文
Scopus记录号	2-s2.0-77949766346
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2514
专题	药学院（分析测试中心）
通讯作者	Zhou, Huiping
作者单位	1.Virginia Commonwealth Univ, Dept Microbiol & Immunol, Dept Internal Med Gastroenterol, POB 980678, Richmond, VA 23298 USA; 2.Virginia Commonwealth Univ, McGuire Vet Affairs Med Ctr, Richmond, VA 23298 USA; 3.Wenzhou Med Coll, Sch Pharm, Wenzhou, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Huiping,Sun, Lixin,Xiao, Jian,et al. Endoplasmic Reticulum Stress and Atherosclerosis[J]. CURRENT HYPERTENSION REVIEWS,2022,6(1):66-71.
APA	Zhou, Huiping., Sun, Lixin., Xiao, Jian., Zhang, Luyong., Li, Xiaokun., ... & Hylemon, Phillip B.. (2022). Endoplasmic Reticulum Stress and Atherosclerosis. CURRENT HYPERTENSION REVIEWS, 6(1), 66-71.
MLA	Zhou, Huiping,et al."Endoplasmic Reticulum Stress and Atherosclerosis".CURRENT HYPERTENSION REVIEWS 6.1(2022):66-71.