Idazoxan attenuates spinal cord injury by enhanced astrocytic activation and reduced microglial activation in rat experimental autoimmune encephalomyelitis

doi:10.1016/j.brainres.2008.11.059

科研成果详情

题名	Idazoxan attenuates spinal cord injury by enhanced astrocytic activation and reduced microglial activation in rat experimental autoimmune encephalomyelitis
作者	Wang, Xin-Shi1,2; Chen, Yan-Yan 1,2; Shang, Xiao-Feng 1,2; Zhu, Zhen-Guo1,2; Chen, Guo-Qian1,2; Han, Zhao1,2; Sha, Bei 1,2; Yang, Hui-Min1,2; Xu, Hui-Qin1,2; Chen, Jiang-Fan 3; Zheng, Rony-Yuan 1,2
发表日期	2009-02-09
发表期刊	BRAIN RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Idazoxan Experimental autoimmune encephalomyelitis Microglia Astrocyte Cytokines
其他关键词	FIBRILLARY ACIDIC PROTEIN ; NITRIC-OXIDE SYNTHASE ; MYELIN BASIC-PROTEIN ; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS ; GROWTH-FACTOR ; IMIDAZOLINE RECEPTORS ; ANTIGEN-EXPRESSION ; GLUTAMATE RELEASE ; CALCIUM-CHANNEL ; BINDING-SITES
摘要	Idazoxan, an imidazoline 2 receptor (I2R) ligand, has been shown to protect against brain injury in several animal models of neurological disorders. In the present study we investigated the effect of idazoxan on experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. EAE was induced by immunizing Wistar rats with guinea pig spinal cord homogenates emulsified in CFA, followed by daily treatment of idazoxan (0, 0.5 mg/kg, 1.5 mg/kg, 4.5 mg/kg, i.p, bid) for 10 days. The results showed that the treatment of idazoxan (1.5 mg/kg and 4.5 mg/kg) significantly decreased the incidence and alleviated inflammatory cell infiltration and demyelination in spinal cords and cerebral cortex. Furthermore, the protective effect of idazoxan on EAE was associated with the enhanced astrocytic activation and attenuated microglial activation and with the subsequent down-regulated expression of proinflammatory cytokines IL-12p40 and IFN-gamma and up-regulated expression of anti-inflammatory cytokines IL-10 and TGF-beta(1). Thus, the daily treatment of the I2R ligand idazoxan for 10 days attenuates EAE pathology by differential modulation of astrocytic and microglial activations, raising a possibility that the I2R ligand may be a novel strategy for treating EAE. (C) 2008 Elsevier B.V. All rights reserved.
资助项目	Zhejiang Natural Science FoundationNatural Science Foundation of Zhejiang Province [Y204133]; Natural Science Foundation of CHINANational Natural Science Foundation of China (NSFC) [30470611]
出版者	ELSEVIER
出版地	AMSTERDAM
ISSN	0006-8993
EISSN	1872-6240
卷号	1253 页码:198-209
DOI	10.1016/j.brainres.2008.11.059
页数	12
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:000263738600022
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	19083996
通讯作者地址	[Zheng, Rony-Yuan]Wenzhou Med Coll, Dept Neurol, Affiliated Hosp 1, 2 Fuxue Lane, Wenzhou 325000, Zhejiang, Peoples R China.
引用统计	被引频次：23[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2254
专题	药学院（分析测试中心）_实验神经生物研究所
通讯作者	Zheng, Rony-Yuan
作者单位	1.Wenzhou Med Coll, Dept Neurol, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China; 2.Wenzhou Med Coll, Res Inst Expt Neurobiol, Wenzhou 325000, Zhejiang, Peoples R China; 3.Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
第一作者单位	药学院（分析测试中心）_实验神经生物研究所
推荐引用方式 GB/T 7714	Wang, Xin-Shi,Chen, Yan-Yan,Shang, Xiao-Feng,et al. Idazoxan attenuates spinal cord injury by enhanced astrocytic activation and reduced microglial activation in rat experimental autoimmune encephalomyelitis[J]. BRAIN RESEARCH,2009,1253:198-209.
APA	Wang, Xin-Shi., Chen, Yan-Yan., Shang, Xiao-Feng., Zhu, Zhen-Guo., Chen, Guo-Qian., ... & Zheng, Rony-Yuan. (2009). Idazoxan attenuates spinal cord injury by enhanced astrocytic activation and reduced microglial activation in rat experimental autoimmune encephalomyelitis. BRAIN RESEARCH, 1253, 198-209.
MLA	Wang, Xin-Shi,et al."Idazoxan attenuates spinal cord injury by enhanced astrocytic activation and reduced microglial activation in rat experimental autoimmune encephalomyelitis".BRAIN RESEARCH 1253(2009):198-209.