The Miraculous Asian Fruit Baccaurea motleyana Müll. Arg. (Rambai): Exploring the Phyto-Pharmacological Potentials of Fruit Peel Through GC-MS/MS, In Vitro, In Vivo, and In Silico Approaches

doi:10.1002/cbdv.202402444

科研成果详情

题名	The Miraculous Asian Fruit Baccaurea motleyana Müll. Arg. (Rambai): Exploring the Phyto-Pharmacological Potentials of Fruit Peel Through GC-MS/MS, In Vitro, In Vivo, and In Silico Approaches
作者	Saima Jahan Riti 1; Suriya Akter Shompa 1; Hasin Hasnat 1; Md Mirazul Islam 1; Safaet Alam 2; Sagar Ghosh 1; Tanoy Saha 1; Chunlai Zeng3; Chuxiao Shao4; Shuanghu Wang4; Peiwu Geng4; Abdullah Al Mamun 4
发表日期	2024-12-11
发表期刊	Chemistry & biodiversity 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	antidepressant antimicrobial antioxidant baccaurea motleyana cytotoxic gc–MS/MS molecular docking rambai
其他关键词	ANTIMICROBIAL ACTIVITY ; MEDICINAL-PLANTS ; ANTIOXIDANT ; EXTRACTS
摘要	Baccaurea motleyana Müll. Arg. (Rambai), an Asian fruit belonging to the Phyllanthaceae family, is cultivated throughout Southeast Asia and has been traditionally utilized in folk medicine to address eye discomfort, digestive issues, insomnia, and fevers. This study of the peel employed four Kupchan fractions (PSF, DSF, ESF, and ASF) obtained from the methanol extract of the peel of B. motleyana for in vitro assessments, including antioxidant cytotoxicity and antimicrobial activities. The crude methanol extract was also used for in vivo evaluations, focusing on antidiarrheal and antidepressant effects, complemented by phytochemical screening and analysis using GC-MS/MS. The investigation of B. motleyana methanol peel extract identified 20 phytochemicals, with primary constituents, including phenol, 3,5-bis(1,1-dimethylethyl) (26.14%) and 1-heptadec-1-ynyl-cyclohexanol (23.12%). The extract exhibited potent antioxidant activity (IC50: 9.43 µg/mL) and cytotoxicity (LC50: 6.01 µg/mL). The most significant antidiarrheal effect was observed at a dosage of 400 mg/kg. Molecular docking studies revealed that compounds, such as C9, C2, and C19, displayed noteworthy binding affinities against glutathione reductase (-6.3 kcal/mol), urease oxidase (-6 kcal/mol), and monoamine oxidase A (-6.5 kcal/mol) receptors. In summary, our study demonstrates that fruits, like Rambai, could serve as a promising source for therapeutics and drug development in Asian countries
资助项目	Public Welfare Technology Research Funding Project of Zhejiang [LTGY24H100002, LTGY23H160034]; Key Research and Development Project of Lishui [2022ZDYF23]; Post-Doctoral Research Start-Up Fund of Lishui People's Hospital, Zhejiang, China [2023bsh001]
出版者	WILEY-V C H VERLAG GMBH
ISSN	1612-1872
EISSN	1612-1880
DOI	10.1002/cbdv.202402444
页数	26
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS记录号	WOS:001395317400001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	39663189
SCOPUSEID	2-s2.0-85215114075
通讯作者地址	[Al Mamun, Abdullah]Wenzhou Med Univ, Affiliated Hosp 1, Lishui Peoples Hosp, Cent Lab Lishui Hosp,Lishui Univ, Lishui, Zhejiang, Peoples R China.
Scopus学科分类	Bioengineering;Biochemistry;Chemistry (all);Molecular Medicine;Molecular Biology
SCOPUS_ID	SCOPUS_ID:85215114075
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/225223
专题	第一临床医学院（信息与工程学院）、附属第一医院附属第一医院
作者单位	1.Department of Pharmacy, School of Pharmaceutical Sciences, State University of Bangladesh, Dhaka, Bangladesh.; 2.Chemical Research Division, BCSIR Dhaka Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh.; 3.Department of Cardiology, The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang, China.; 4.Central Laboratory of The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang, China.
通讯作者单位	附属第一医院
推荐引用方式 GB/T 7714	Saima Jahan Riti,Suriya Akter Shompa,Hasin Hasnat,et al. The Miraculous Asian Fruit Baccaurea motleyana Müll. Arg. (Rambai): Exploring the Phyto-Pharmacological Potentials of Fruit Peel Through GC-MS/MS, In Vitro, In Vivo, and In Silico Approaches[J]. Chemistry & biodiversity,2024.
APA	Saima Jahan Riti., Suriya Akter Shompa., Hasin Hasnat., Md Mirazul Islam., Safaet Alam., ... & Abdullah Al Mamun. (2024). The Miraculous Asian Fruit Baccaurea motleyana Müll. Arg. (Rambai): Exploring the Phyto-Pharmacological Potentials of Fruit Peel Through GC-MS/MS, In Vitro, In Vivo, and In Silico Approaches. Chemistry & biodiversity.
MLA	Saima Jahan Riti,et al."The Miraculous Asian Fruit Baccaurea motleyana Müll. Arg. (Rambai): Exploring the Phyto-Pharmacological Potentials of Fruit Peel Through GC-MS/MS, In Vitro, In Vivo, and In Silico Approaches".Chemistry & biodiversity (2024).