Identification of circulating risk biomarkers for cognitive decline in a large community-based population in Chongqing China

doi:10.1002/alz.14443

科研成果详情

题名	Identification of circulating risk biomarkers for cognitive decline in a large community-based population in Chongqing China
作者	Kang, Yu 1,2; Feng, Zijuan 1; Zhang, Qian 3; Liu, Mingjing 1; Li, Yanhua 1; Yang, Huan 1; Zheng, Lingling 1; Cheng, Chunjiang 1; Zhou, Weitao 1; Lou, Dandan 1; Li, Xiaoyong 1; Chen, Liangping 1; Feng, Yi 1; Duan, Xiaoling 1; Duan, Jianzhong 1; Yu, Mengjiao 1; Yang, Shou 1; Liu, Yuhang 1; Wang, Xin 4,5; Deng, Bo 4,5; Liu, Chenghui 4,5; Yao, Xiuqing 4,5; Zhu, Chi 4,5; Liang, Chunrong 4,5; Zeng, Xiaolong 4,5; Ren, Sisi 6; Li, Qunying 4,5; Zhong, Yin 6; Yan, Yong 7; Meng, Huaqing 8; Zhong, Zhaohui 6; Zhang, Yong 6; Kang, Jun 6; Luan, Xiaoqian9,10; Pan, Sipei9,10; Wu, Yili9; Li, Tingyu 1; Song, Weihong1,2,9,10; Zhang, Yun 11,12
发表日期	2024-12-23
发表期刊	ALZHEIMERS & DEMENTIA 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Alzheimer's disease blood biomarkers dementia elderly population mild cognitive impairment
其他关键词	PLASMA NEUROFILAMENT LIGHT ; ALZHEIMERS-DISEASE ; DIABETES-MELLITUS ; DEMENTIA ; IMPAIRMENT ; ASSOCIATION ; EPILEPSY ; MARKER ; IMPACT ; PREVALENCE
摘要	INTRODUCTION: This study aims to investigate the relationship between blood-based pathologies and established risk factors for cognitive decline in the community-based population of Chongqing, a region with significant aging. METHODS: A total of 26,554 residents aged 50 years and older were recruited. Multinomial logistic regression models were applied to assess the risk factors of cognition levels. Propensity score matching and linear mixed effects models were used to evaluate the relationship between key risk factors and the circulating biomarkers. RESULTS: Shared and distinct risk factors for MCI and dementia were identified. Age, lower education, medical history of stroke, hypertension, and epilepsy influenced mild cognitive impairment (MCI) progression to dementia. Correlations between key risk factors and circulating neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), amyloid beta protein (A beta)40, and A beta 42/A beta 40 ratio suggest underlying mechanisms contributing to cognitive impairment. DISCUSSION: The common and distinct risk factors across cognitive decline stages emphasize the need for tailored interventions. The correlations with blood biomarkers provide insights into potential management targets.
资助项目	National Natural Science Foundation of China; Canadian Institutes of Health Research [TAD-117948]; Canada Research Chair in Alzheimer's Disease; China Scholarship Council's Visiting Scholarship; [81161120498]; [82293642]; [82230043]; [82150710557]; [82201576]
出版者	WILEY
ISSN	1552-5260
EISSN	1552-5279
DOI	10.1002/alz.14443
页数	15
WOS类目	Clinical Neurology
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:001382159300001
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	39713874
通讯作者地址	[Zhang, Yun]Nanjing Univ, Nanjing Drum Tower Hosp, Med Sch, Dept Neurol,Affiliated Hosp, 321 Zhongshan Rd, Nanjing 210008, Peoples R China. ; [Song, Weihong]Wenzhou Med Univ, Affiliated Hosp 1, Inst Aging, Ctr Geriatr Med, Wenzhou 325000, Zhejiang, Peoples R China. ; [Li, Tingyu]Chongqing Med Univ, Chongqing Key Lab Child Neurodev & Cognit Disorder, Childrens Hosp, Chongqing 400016, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/224787
专题	附属第一医院
通讯作者	Li, Tingyu; Song, Weihong; Zhang, Yun
作者单位	1.Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Chongqing Key Lab Child Neurodev & Cognit Disorder, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China; 2.Univ British Columbia, Dept Psychiat, Townsend Family Labs, Vancouver, BC, Canada; 3.BC Childrens Hosp, Clin Res Support Unit, Res Inst, Vancouver, BC, Canada; 4.Third Mil Med Univ, Dept Neurol, Chongqing, Peoples R China; 5.Third Mil Med Univ, Daping Hosp, Ctr Clin Neurosci, Chongqing, Peoples R China; 6.Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China; 7.Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; 8.First Affiliated Hosp Chongqing Med Univ, Dept Gastroenterol, Chongqing, Peoples R China; 9.Wenzhou Med Univ, Affiliated Hosp 1, Inst Aging, Ctr Geriatr Med,Key Lab Alzheimers Dis Zhejiang Pr, Wenzhou, Zhejiang, Peoples R China; 10.Zhejiang Lab Regenerat Med Vis & Brain Hlth, Oujiang Lab, Wenzhou, Zhejiang, Peoples R China; 11.Nanjing Univ, Nanjing Drum Tower Hosp, Med Sch, Dept Neurol,Affiliated Hosp, 321 Zhongshan Rd, Nanjing 210008, Peoples R China; 12.Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing, Peoples R China
通讯作者单位	附属第一医院
推荐引用方式 GB/T 7714	Kang, Yu,Feng, Zijuan,Zhang, Qian,et al. Identification of circulating risk biomarkers for cognitive decline in a large community-based population in Chongqing China[J]. ALZHEIMERS & DEMENTIA,2024.
APA	Kang, Yu., Feng, Zijuan., Zhang, Qian., Liu, Mingjing., Li, Yanhua., ... & Zhang, Yun. (2024). Identification of circulating risk biomarkers for cognitive decline in a large community-based population in Chongqing China. ALZHEIMERS & DEMENTIA.
MLA	Kang, Yu,et al."Identification of circulating risk biomarkers for cognitive decline in a large community-based population in Chongqing China".ALZHEIMERS & DEMENTIA (2024).