Stimuli-responsive hydrogel microspheres encapsulated with tumor-cell-derived microparticles for malignant ascites treatment

doi:10.1016/j.actbio.2024.11.034

科研成果详情

题名	Stimuli-responsive hydrogel microspheres encapsulated with tumor-cell-derived microparticles for malignant ascites treatment
作者	Zhu, Shishi 1; Shou, Xin 2; Kuang, Gaizhen1; Kong, Xiuyan1; Sun, Weijian1; Zhang, Qingfei 1,2; Xia, Jinglin1,3
发表日期	2024
发表期刊	Acta Biomaterialia 影响因子和分区
语种	英语
原始文献类型	Article in Press
关键词	Cell death Controlled drug delivery Microgels Microspheres Nanocrystalline alloys Phosphate coatings Sensory feedback Targeted drug delivery Ascite Hydrogel microspheres Immunotherapy Micro particles Microcarriers Stimuli-responsive Stimulus-responsive microcarrier Tumor therapy Tumor-cell-derived microparticle Tumour cells
摘要	Tumor-cell-derived microparticles (TMPs) have been recognized as chemotherapeutic drug carriers and immunomodulators for anti-tumor therapy. Research in the clinical application of TMPs has been devoted to developing an effective delivery formulation that could enhance their therapeutic effects. Here, we propose thermal-responsive agarose hydrogel microspheres (MTX-TMPs@MSs) with encapsulation of Methotrexate (MTX)-packaging TMPs (MTX-TMPs) and black phosphorus quantum dots (BPQDs) by microfluidic technology for synergistic treatment of malignant ascites. The laden MTX-TMPs, separated from apoptotic tumor cells, could target tumor cells for the delivery of chemotherapy drugs and modulate the tumor immune microenvironment. Under near-infrared (NIR) induced thermal stimulation, MTX-TMPs could be controllably released from the low-melting-point agarose matrix hydrogel microspheres for chemotherapy (CHT) and immunotherapy (IMT). In addition, benefiting from photothermal therapy (PTT)-induced tumor immunogenic death, the anti-tumor immune response triggered by MTX-TMPs was further enhanced. Based on these features, the MTX-TMPs@MSs could remarkably eliminate tumor cells in vitro and obviously suppress tumor growth in vivo through synergistic PTT, CHT, and IMT. Therefore, it is envisaged that this TMPs-integrated microcarrier will have promising applications in clinical tumor therapy. Statement of Significance: Primary liver cancer ranks third among the causes of cancer deaths globally, with hepatocellular carcinoma (HCC) being the most common type. In particular, patients with advanced HCC accompanied by malignant ascites, a common complication, indicate tumor metastasis and a poor prognosis. In this paper, we developed stimuli-responsive hydrogel microspheres from microfluidics for the delivery of methotrexate (MTX)-loaded tumor-cell-derived microparticles (MTX-TMPs) for synergistic chemotherapy, photothermal therapy, and immunotherapy. The release of MTX-TMPs from hydrogel microspheres could be on-demand controlled through BPQDs-mediated photothermal stimulus. On the other hand, BPQDs-mediated mild hyperthermia cooperatesss with MTX-TMPs-induced chemotherapy could participate in remodeling the tumor immunosuppressive microenvironment. Thus, the prepared microcarrier system holds great promise for tumor therapy. © 2024 Acta Materialia Inc.
出版者	Acta Materialia Inc
ISSN	1742-7061
EISSN	1878-7568
DOI	10.1016/j.actbio.2024.11.034
收录类别	EI ; PUBMED
EI入藏号	20244817437343
EI主题词	Chemotherapy
EI分类号	101.6 ; 102.1.1 ; 102.1.2.1 ; 102.2.1 ; 103 ; 1301.4.1 ; 201.9.2.1 ; 208.2 ; 214 ; 761 Nanotechnology ; 801.2 Biochemistry
URL	查看原文
PubMed ID	39586349
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/223714
专题	附属第一医院
通讯作者	Sun, Weijian
作者单位	1.Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, First Affiliated Hospital of Wenzhou Medical University, Wenzhou; 325035, China 2.Wenzhou Institute, University of Chinese Academy of Sciences, Zhejiang, Wenzhou; 325001, China 3.National Medical Center & National Clinical Research Center for Interventional Medicine. Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai; 200032, China
第一作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhu, Shishi,Shou, Xin,Kuang, Gaizhen,et al. Stimuli-responsive hydrogel microspheres encapsulated with tumor-cell-derived microparticles for malignant ascites treatment[J]. Acta Biomaterialia,2024.
APA	Zhu, Shishi., Shou, Xin., Kuang, Gaizhen., Kong, Xiuyan., Sun, Weijian., ... & Xia, Jinglin. (2024). Stimuli-responsive hydrogel microspheres encapsulated with tumor-cell-derived microparticles for malignant ascites treatment. Acta Biomaterialia.
MLA	Zhu, Shishi,et al."Stimuli-responsive hydrogel microspheres encapsulated with tumor-cell-derived microparticles for malignant ascites treatment".Acta Biomaterialia (2024).