Cascade catalytic multilayer modified intraocular lens for enhanced and safer posterior capsule opacification prevention

doi:10.1016/j.actbio.2024.12.016

科研成果详情

题名	Cascade catalytic multilayer modified intraocular lens for enhanced and safer posterior capsule opacification prevention
作者	Jia, Qingqing; Wei, Youfei; Hu, Yulin; Yang, Yuexin; Hong, Wenxin; Huang, Huiying; Lin, Quankui
发表日期	2024
发表期刊	Acta Biomaterialia 影响因子和分区
语种	英语
原始文献类型	Article in Press
关键词	Cell death Contact lenses Drug interactions Ionization of gases Mesopores Mesoporous materials Optical instrument lenses Photoionization Reactive oxygen species Silica nanoparticles After cataract Cascade catalytic reaction Catalytic nanoparticle Catalytic reactions External energy Intraocular Layer-by-layer self assembly techniques Posterior capsule opacification Reactive oxygen species Surface-modification
摘要	Posterior capsule opacification (PCO) is the most common complication after cataract surgery. It is primarily caused by the proliferation, migration, and adhesion of residual lens epithelial cells within the capsular bag following phacoemulsification and intraocular lens (IOL) implantation. Although investigations of surface modification onto IOL have partially reduced PCO development in recent years, there are still challenges in long-term efficacy and intraocular biocompatibility. In this study, a cascade catalytic system is constructed using natural enzymes onto mesoporous silica nanoparticles (MSNs), which are subsequently fixed to the surface of IOL through layer-by-layer self-assemble of alternating positive and negative charges. The cascade catalytic reaction is trigged simply by glucose within the pouch to produce reactive oxygen species (ROS) without introducing any toxic drugs or external energy, attempting to minimize the possible toxic side effects to surrounding tissues. In vivo and in vitro experiments indicate the effective inhibition of PCO and favorable intraocular compatibility of the cascade catalytic platform modified IOL. More importantly, the modified IOL retains good optical performance and imaging quality, demonstrating promising prospects for application. This study provides a new possibility for enhanced and safer PCO prevention, playing great significance in clinical treatment. Statement of Significance: Cascade catalytic nanoparticles-loaded multilayer modified IOL is obtained via LbL technique. The multilayer coating improves both the loading capacity and the activity of the cascade catalytic nanoparticles. The cascade catalytic reaction is trigged by glucose, producing ROS that efficiently induces apoptosis and death of remaining cells on IOL without introducing any toxic drugs or external energy. The innovative IOL provides a promising approach for enhanced and safer prevention of PCO. © 2024 Acta Materialia Inc.
出版者	Acta Materialia Inc
ISSN	1742-7061
EISSN	1878-7568
DOI	10.1016/j.actbio.2024.12.016
收录类别	EI ; PUBMED
EI入藏号	20245017523892
EI主题词	Intraocular lenses
EI分类号	102.2 ; 103 ; 203 ; 214 ; 741.3 Optical Devices and Systems ; 761 Nanotechnology ; 801.1 Chemistry, General ; 802.2 Chemical Reactions
URL	查看原文
PubMed ID	39644940
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/223711
专题	眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者	Huang, Huiying
作者单位	National Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou; 325027, China
第一作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
第一作者的第一单位	眼视光学院（生物医学工程学院）、附属眼视光医院
推荐引用方式 GB/T 7714	Jia, Qingqing,Wei, Youfei,Hu, Yulin,et al. Cascade catalytic multilayer modified intraocular lens for enhanced and safer posterior capsule opacification prevention[J]. Acta Biomaterialia,2024.
APA	Jia, Qingqing., Wei, Youfei., Hu, Yulin., Yang, Yuexin., Hong, Wenxin., ... & Lin, Quankui. (2024). Cascade catalytic multilayer modified intraocular lens for enhanced and safer posterior capsule opacification prevention. Acta Biomaterialia.
MLA	Jia, Qingqing,et al."Cascade catalytic multilayer modified intraocular lens for enhanced and safer posterior capsule opacification prevention".Acta Biomaterialia (2024).