Effects of La/Mn-Ceria&TiO2 heterojunction on titanium implants: Improved regenerative repair of diabetic bone with enhanced antioxidant characteristics

doi:10.1016/j.ceramint.2024.11.198

科研成果详情

题名	Effects of La/Mn-Ceria&TiO2 heterojunction on titanium implants: Improved regenerative repair of diabetic bone with enhanced antioxidant characteristics
作者	Tang, Xiaoting1; Lin, Dini 2; Xu, Keyuan1; Yun xiang1; Tao, Ran1; Cai, Chenxi1; Shen, Yiding 3; Fang, Kai 3; Ma, Pingping1; Shen, Xinkun2; Deng, Zhennan1
发表日期	2024
发表期刊	Ceramics International 影响因子和分区
语种	英语
原始文献类型	Article in Press
关键词	Aluminum coatings Cerium oxide Lanthanum compounds Layered semiconductors Manganese compounds Metal implants Oxygen vacancies Reactive oxygen species Semiconductor doping Superoxide dismutase TiO2 nanoparticles Ce 3+ CeO 2 Hyperglycaemia Implant failures Ion-doping Osseointegration Oxygen vacancy concentration TiO 2 Titania Titanium implants
摘要	Hyperglycemia-induced oxidative stress (OS) plays a crucial role in implant osseointegration and often results in implant failure in patients with diabetes. Implants modified with cerium nanoparticles (CeO2-NPs) have gained significant attention owing to their remarkable oxidase-mimetic activity and therapeutic potential. Increasing the Ce3+ content and oxygen vacancy concentration in CeO2-NPs enhances the catalytic activity of CeO2-NPs. In this study, we synthesized lanthanide (La)/manganese (Mn) -doped CeO2-NPs composite coatings (La-CNPs and Mn-CNPs) on alkali-etched Ti substrates using a one-step hydrothermal method. Our findings indicate that the integration of La/Mn doping, in conjunction with a titanium dioxide carrier, augmented both the Ce3+ content and the oxygen vacancy concentration in La-CNPs and Mn-CNPs. By analyzing their electronic energy band structures, we found that La-CNPs exhibited superior catalase activity, whereas Mn-CNPs outperformed them in terms of superoxide dismutase activity. Under OS conditions, La-CNPs and Mn-CNPs (especially Mn-CNPs) markedly reduced intracellular reactive oxygen species levels in MC3T3-E1 cells, promoting their proliferation and osteogenic differentiation. Complementing these in vitro observations, in vivo trials underscored the capability of Mn-CNPs to enhance osteointegration in surrounding implants in diabetic rat models. Consequently, Mn-CNPs coatings present a promising avenue for augmenting the efficacy of implant therapies, especially in patients with diabetes. © 2024 Elsevier Ltd and Techna Group S.r.l.
出版者	Elsevier Ltd
ISSN	0272-8842
DOI	10.1016/j.ceramint.2024.11.198
收录类别	EI
EI入藏号	20244817436944
EI主题词	Titanium dioxide
EI分类号	101.2.3 ; 101.3 ; 1301.4.1 ; 202.3.2 ; 202.7.2 ; 208.2 ; 712.1 Semiconducting Materials ; 712.1.2 Compound Semiconducting Materials ; 761 Nanotechnology ; 801.1 Chemistry, General ; 804.2 Inorganic Compounds
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/223709
专题	口腔医学院、附属口腔医院其他_附属第三医院（瑞安市人民医院）
通讯作者	Ma, Pingping; Shen, Xinkun; Deng, Zhennan
作者单位	1.School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou; 325027, China 2.Ruian People's Hospital, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou; 325016, China 3.Department of Stomatology, Shaoxing Hospital of Traditional Medicine, Shaoxing; 312000, China
第一作者单位	口腔医学院、附属口腔医院
第一作者的第一单位	口腔医学院、附属口腔医院
推荐引用方式 GB/T 7714	Tang, Xiaoting,Lin, Dini,Xu, Keyuan,et al. Effects of La/Mn-Ceria&TiO2 heterojunction on titanium implants: Improved regenerative repair of diabetic bone with enhanced antioxidant characteristics[J]. Ceramics International,2024.
APA	Tang, Xiaoting., Lin, Dini., Xu, Keyuan., Yun xiang., Tao, Ran., ... & Deng, Zhennan. (2024). Effects of La/Mn-Ceria&TiO2 heterojunction on titanium implants: Improved regenerative repair of diabetic bone with enhanced antioxidant characteristics. Ceramics International.
MLA	Tang, Xiaoting,et al."Effects of La/Mn-Ceria&TiO2 heterojunction on titanium implants: Improved regenerative repair of diabetic bone with enhanced antioxidant characteristics".Ceramics International (2024).