A multi-functional composite nanocatalyst for the synthesis of biologically active pyrazolopyranopyrimidines: Multifaceted antimicrobial, antioxidant, and anticancer activities

doi:10.1007/s42114-024-01021-2

科研成果详情

题名	A multi-functional composite nanocatalyst for the synthesis of biologically active pyrazolopyranopyrimidines: Multifaceted antimicrobial, antioxidant, and anticancer activities
作者	Xu, Yi1; Nezhad, Shefa Mirani 2; Zare, Ehsan Nazarzadeh 2; Pourmousavi, Seied Ali 2; Doostian, Alireza 3; Ren, Junna 4; Paiva-Santos, Ana Claudia 5,6; Wu, Aimin 7; Sethi, Gautam 8,9; Rossi, Filippo 10; Wang, Xiangdong 11; Makvandi, Pooyan 12
发表日期	2025-02
发表期刊	ADVANCED COMPOSITES AND HYBRID MATERIALS 影响因子和分区
语种	英语
原始文献类型	Article
关键词	UiO-66-NH2 Pyrazolopyranopyrimidines Nanocomposites Multi-functional catalyst
其他关键词	METAL-ORGANIC FRAMEWORKS ; GREEN SYNTHESIS ; ONE-POT ; CATALYST ; ANTIBACTERIAL ; WATER ; LUMINESCENT ; ADSORPTION ; SEPARATION ; REMOVAL
摘要	Metal-organic frameworks (MOFs) are crystalline entities made up of metal ions or clusters coordinated to typically rigid organic molecules, creating three-dimensional porous networks. The integration of both inorganic and organic components results in almost unlimited chemical and structural possibilities. This potential has led to MOF for catalytic applications attracting great interest. In this context, a novel multifunctional magnetic nanocomposite, was synthesized for the efficient and sustainable production of biologically active pyrazolopyranopyrimidines. This composite (Fe3O4@PmPDA@UiO-66-NH2) combines the advantages of magnetic nanoparticles (Fe3O4), a polymer coating poly(meta-phenylenediamine), and a metal-organic framework (UiO-66-NH2). The nanocomposite as a multifunctional magnetic catalyst has been synthesized in three steps including (1) synthesis of Fe(3)O(4 )nanoparticles by co-precipitation technique (2) preparation of UiO-66-NH2 through a solvothermal method, (3) preparation of nanoparticles-polymer-MOF hybrid nanocomposite using Fe3O4, PmPDA, and UiO-66-NH2 . The prepared catalyst was fully characterized by XRD, FTIR, EDX, FESEM, TGA, and VSM analyses. The Fe3O4@PmPDA@UiO-66-NH2 nanocomposite was used as a catalyst for the synthesis of pyrazolopyranopyrimidines. Various pyrazolopyranopyrimidine products were synthesized in remarkable yields (90-96%) in a short reaction time (10-80 min). The biological activity of pyrazolopyranopyrimidines was studied. The anticancer evaluation of some pyrazolopyranopyrimidines was studied on the survival rate of HepG2 cancer cells and NIH/3T3 fibroblast cells by using an MTT assay. A greater inhibition of cell viability was obtained after 48 h of incubation with higher concentrations (150 mu g/L) of pyrazolopyranopyrimidines compounds, demonstrating the anti-proliferative effects of these agents. Additionally, in most cases, the viability of fibroblast cells exhibited a comparatively minor decline when incubated with pyrazolopyranopyrimidines as opposed to HepG2 cells. Furthermore, these compounds have an antioxidant activity between 85.3 and 98.3%. Additionally, their antimicrobial activity was evaluated using the Kirby-Bauer disk diffusion method and showed the highest inhibition zone against Staphylococcus aureus and Escherichia coli of 19 +/- 2.0 and 10 +/- 1.5 mm, respectively.
资助项目	Iran National Science Foundation(INSF) [4026593]
出版者	SPRINGERNATURE
ISSN	2522-0128
EISSN	2522-0136
卷号	8 期号:1
DOI	10.1007/s42114-024-01021-2
页数	22
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Composites
收录类别	SCIE ; SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-85211149764
通讯作者地址	[Zare, Ehsan Nazarzadeh]Damghan Univ, Sch Chem, Damghan 3671645667, Iran. ; [Makvandi, Pooyan]Wenzhou Med Univ, Quzhou Peoples Hosp, Quzhou Affiliated Hosp, Quzhou 324000, Zhejiang, Peoples R China.
Scopus学科分类	Ceramics and Composites;Materials Science (miscellaneous);Polymers and Plastics;Materials Chemistry
SCOPUS_ID	SCOPUS_ID:85211149764
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/223294
专题	其他_温州医科大学附属衢州医院附属第二医院_骨科重点学科实验室
通讯作者	Zare, Ehsan Nazarzadeh; Makvandi, Pooyan
作者单位	1.Wenzhou Med Univ, Quzhou Peoples Hosp, Dept Urol, Nanobiomed Grp,Quzhou Affiliated Hosp, Quzhou, Peoples R China; 2.Damghan Univ, Sch Chem, Damghan 3671645667, Iran; 3.Iran Univ Med Sci, Tehran, Iran; 4.Taiyuan Univ Sci & Technol, Coll Mat Sci & Engn, Taiyuan 030024, Peoples R China; 5.Univ Coimbra, Fac Pharm, Dept Pharmaceut Technol, P-3000548 Coimbra, Portugal; 6.Univ Coimbra, Fac Pharm, REQUIMTE LAQV, Grp Pharmaceut Technol, Coimbra, Portugal; 7.Wenzhou Med Univ, Key Lab Orthopaed Zhejiang Prov, Key Lab Orthopaed Zhejiang Prov, Key Lab Orthopaed Zhejiang Prov,Yuying Childrens H, Wenzhou 325000, Zhejiang, Peoples R China; 8.Natl Univ Singapore, Dept Pharmacol, Singapore 117600, Singapore; 9.Natl Univ Singapore, NUS Ctr Canc Res N2CR, Yong Loo Lin Sch Med, Singapore 117600, Singapore; 10.Politecn Milano Tech Univ, Dept Chem Mat & Chem Engn, I-20133 Milan, Italy; 11.Fudan Univ, Shanghai Med Coll, Zhongshan Hosp, Shanghai Med Coll, Shanghai, Peoples R China; 12.Wenzhou Med Univ, Quzhou Peoples Hosp, Quzhou Affiliated Hosp, Quzhou 324000, Zhejiang, Peoples R China
第一作者单位	其他_温州医科大学附属衢州医院
通讯作者单位	其他_温州医科大学附属衢州医院
第一作者的第一单位	其他_温州医科大学附属衢州医院
推荐引用方式 GB/T 7714	Xu, Yi,Nezhad, Shefa Mirani,Zare, Ehsan Nazarzadeh,et al. A multi-functional composite nanocatalyst for the synthesis of biologically active pyrazolopyranopyrimidines: Multifaceted antimicrobial, antioxidant, and anticancer activities[J]. ADVANCED COMPOSITES AND HYBRID MATERIALS,2025,8(1).
APA	Xu, Yi., Nezhad, Shefa Mirani., Zare, Ehsan Nazarzadeh., Pourmousavi, Seied Ali., Doostian, Alireza., ... & Makvandi, Pooyan. (2025). A multi-functional composite nanocatalyst for the synthesis of biologically active pyrazolopyranopyrimidines: Multifaceted antimicrobial, antioxidant, and anticancer activities. ADVANCED COMPOSITES AND HYBRID MATERIALS, 8(1).
MLA	Xu, Yi,et al."A multi-functional composite nanocatalyst for the synthesis of biologically active pyrazolopyranopyrimidines: Multifaceted antimicrobial, antioxidant, and anticancer activities".ADVANCED COMPOSITES AND HYBRID MATERIALS 8.1(2025).