Dynamic changes of choroidal vasculature and its association with myopia control efficacy in children during 1-year orthokeratology treatment

doi:10.1016/j.clae.2024.102314

科研成果详情

题名	Dynamic changes of choroidal vasculature and its association with myopia control efficacy in children during 1-year orthokeratology treatment
作者	Mengqi Liu1; Jing Huang1; Zhu Xie 1; Yuanyuan Wang 1; Pengqi Wang 1; Ruijing Xia 1; Xinting Liu1; Binbin Su1; Jia Qu1; Xiangtian Zhou2; Xinjie Mao 3; Hao Wu4
发表日期	2024-09-29
发表期刊	Contact lens & anterior eye : the journal of the British Contact Lens Association 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Choriocapillaris Choroidal vascularity Myopia Orthokeratology
摘要	To investigate the dynamic changes of choroidal vasculature and its association in mediating ocular elongation over 1 year of orthokeratology (ortho-k) treatment., This observational study included 8-14 year old myopic children who were willing to receive ortho-k treatment or wear single vision spectacle lenses (SVL). Axial length (AL) and choroidal characteristics, including submacular luminal area (LA), stromal area (SA), total choroidal area (TCA), choroidal vascularity index (CVI), subfoveal choroidal thickness (SFCT) and choriocapillaris flow deficits (CcFD) from OCT/OCTA images, were evaluated at baseline, 3, 6 and 12 months., {AbstractText=After 1 year, AL elongation was significantly less in 25 children treated with ortho-k than in 29 children wearing SVL (0.17 ± 0.14 v.s. 0.28 ± 0.16 mm, P<0.01). In the ortho-k group, LA, SA, TCA and SFCT were significantly increased by 0.033 ± 0.059 mm2, 0.024 ± 0.035 mm2, 0.058 ± 0.087 mm2, 8.9 ± 17.4 μm, respectively, at 3 months (all P<0.05). These parameters returned to near baseline levels over the following 9 months. Meanwhile, CcFD decreased by 0.83 ± 1.09 % over 12 months, but CVI remained steady during this period. No significant changes in these choroidal parameters (except for CcFD, decreased by -0.56 ± 1.23 %) were observed in the SVL group over 12 months. Increases in SFCT, LA, SA and TCA over 12 months were significantly greater in the ortho-k group than in the SVL group. Mediation analyses showed that 44.8 % of effect on inhibiting AL elongation through ortho-k was mediated via TCA (in particular LA).}, The decelerated ocular elongation during ortho-k treatment is accompanied by increases in content of choroidal vascular lumen and stromal component. Dynamic changes of choroidal vasculature provide a possible mechanism underlying myopia control efficacy via ortho-k.
资助项目	Natural Science Foundation of Zhejiang Province[LQ21H120005];National Natural Science Foundation of China[82000931,U20A20364,U23A20438,82388101,82025009];CAMS Innovation Fund for Medical Sciences[2019-I2M-5–048];
ISSN	1367-0484
EISSN	1476-5411
卷号	48 期号:1
DOI	10.1016/j.clae.2024.102314
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	39349350
SCOPUSEID	2-s2.0-85205218537
通讯作者地址	[Mao, Xinjie]Eye Hospital and School of Optometry and Ophthalmology,Wenzhou Medical University,Zhejiang,Wenzhou,325027,China
Scopus学科分类	Ophthalmology;Optometry
SCOPUS_ID	SCOPUS_ID:85205218537
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/223280
专题	眼视光学院（生物医学工程学院）、附属眼视光医院眼视光学院（生物医学工程学院）、附属眼视光医院_视光诊疗中心
作者单位	1.National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.; 2.State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health), Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; Research Unit of Myopia Basic Research and Clinical Prevention and Control, Chinese Academy of Medical Sciences (2019RU025), Wenzhou, Zhejiang 325027, China.; 3.National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China. Electronic address: mxj@mail.eye.ac.cn.; 4.National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China. Electronic address: wuhao@mail.eye.ac.cn.
第一作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
第一作者的第一单位	眼视光学院（生物医学工程学院）、附属眼视光医院
推荐引用方式 GB/T 7714	Mengqi Liu,Jing Huang,Zhu Xie,et al. Dynamic changes of choroidal vasculature and its association with myopia control efficacy in children during 1-year orthokeratology treatment[J]. Contact lens & anterior eye : the journal of the British Contact Lens Association,2024,48(1).
APA	Mengqi Liu., Jing Huang., Zhu Xie., Yuanyuan Wang., Pengqi Wang., ... & Hao Wu. (2024). Dynamic changes of choroidal vasculature and its association with myopia control efficacy in children during 1-year orthokeratology treatment. Contact lens & anterior eye : the journal of the British Contact Lens Association, 48(1).
MLA	Mengqi Liu,et al."Dynamic changes of choroidal vasculature and its association with myopia control efficacy in children during 1-year orthokeratology treatment".Contact lens & anterior eye : the journal of the British Contact Lens Association 48.1(2024).