Maternal COVID-19 infection associated with offspring neurodevelopmental disorders

doi:10.1038/s41380-024-02822-z

科研成果详情

题名	Maternal COVID-19 infection associated with offspring neurodevelopmental disorders
作者	Duan, Lian1; Yin, Huamin1,2; Liu, Jiaxin 2; Wang, Wenhang 2; Huang, Peijun3; Liu, Li 2; Shen, Jingling 2; Wang, Zhendong4
发表日期	2024-11-09
发表期刊	MOLECULAR PSYCHIATRY 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
其他关键词	NORMALIZATION ; TRANSCRIPTOME
摘要	Maternal COVID-19 infection increases the incidence of neurodevelopmental disorders (NDDs) in offspring, although the underlying mechanisms have not been elucidated. This study demonstrated that COVID-19 infection during pregnancy disrupted the balance of maternal and fetal immune environments, driving alterations in astrocytes, endothelial cells, and excitatory neurons. A risk score was established using 47 unique genes in the single-cell transcriptome of gestational mothers. The high risk score in CD4 proliferating T cell level served as an indicator for increased risk of offspring NDDs. Summary-based Mendelian randomization and phenome-wide association study analyses were conducted to identify the causal association of the transcriptional changes with the increased risk of offspring NDDs. Additionally, 10 drugs were identified as potential therapeutic candidates. Our findings support a model where the maternal COVID-19 infection changed the levels of CD4 proliferating T cells, leading to the alterations of astrocytes, endothelial cells, and excitatory neurons in offspring, contributing to the increased risk of NDDs in these individuals.
资助项目	National Natural Science Foundation of China (National Science Foundation of China) [81701350, 31671252]; National Natural Science Foundation of China [2023RC205]; Health Technology Plan of Zhejiang Province
出版者	SPRINGERNATURE
ISSN	1359-4184
EISSN	1476-5578
DOI	10.1038/s41380-024-02822-z
页数	11
WOS类目	Biochemistry & Molecular Biology ; Neurosciences ; Psychiatry
WOS研究方向	Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry
WOS记录号	WOS:001350455900002
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	39521839
通讯作者地址	[Shen, Jingling]Wenzhou Univ, Inst Life Sci, Coll Life & Environm Sci, Wenzhou 325035, Peoples R China. ; [Wang, Zhendong]Wenzhou Med Univ, Affiliated Hosp 1, Key Lab Intervent Pulmonol Zhejiang Prov, Wenzhou 325000, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/221297
专题	第一临床医学院（信息与工程学院）、附属第一医院_中心实验室药学院（分析测试中心）附属第一医院
通讯作者	Shen, Jingling; Wang, Zhendong
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Cent Lab, Wenzhou 325000, Peoples R China; 2.Wenzhou Univ, Inst Life Sci, Coll Life & Environm Sci, Wenzhou 325035, Peoples R China; 3.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China; 4.Wenzhou Med Univ, Affiliated Hosp 1, Key Lab Intervent Pulmonol Zhejiang Prov, Wenzhou 325000, Peoples R China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_中心实验室
通讯作者单位	附属第一医院
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_中心实验室
推荐引用方式 GB/T 7714	Duan, Lian,Yin, Huamin,Liu, Jiaxin,et al. Maternal COVID-19 infection associated with offspring neurodevelopmental disorders[J]. MOLECULAR PSYCHIATRY,2024.
APA	Duan, Lian., Yin, Huamin., Liu, Jiaxin., Wang, Wenhang., Huang, Peijun., ... & Wang, Zhendong. (2024). Maternal COVID-19 infection associated with offspring neurodevelopmental disorders. MOLECULAR PSYCHIATRY.
MLA	Duan, Lian,et al."Maternal COVID-19 infection associated with offspring neurodevelopmental disorders".MOLECULAR PSYCHIATRY (2024).