What is the impact of acute endocrine and metabolic alterations on long-term ischemic stroke prognosis: a prospective study

doi:10.1186/s12877-024-05453-9

科研成果详情

题名	What is the impact of acute endocrine and metabolic alterations on long-term ischemic stroke prognosis: a prospective study
作者	Chunyang Pang1; Yufei Chen2; Yinuo Chen 3; Er Lin 3; Xinnan Pan 3; Yiting Xu 1; Huan Yu 2; Wanli Zhang1; Binbin Deng4,5
发表日期	2024-10-22
发表期刊	BMC geriatrics 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Acute ischemic stroke Stress Stress hyperglycemia Stroke prognosis Thyroid hormones
摘要	Post-stroke stress can trigger instant survival but its influence on long-term ischemic stroke outcomes remains controversial. Thus, we sought to explore the associations of acute post-stroke stress evidenced by endocrine and metabolic changes, with long-term ischemic stroke outcomes., Admissions for acute ischemic stroke within seven days of onset were prospectively recruited to determine acute endocrine and metabolic variations measured by thyroid parameters and the stress hyperglycemia ratio (SHR). Long-term ischemic stroke prognoses were followed up for one year, with the primary outcome being a modified Rankin Scale score of 3 to 6., A total of 887 patients were enrolled, of which 535 reached the final one-year followed up at a poor prognosis rate of 29.3%. Patients with poor outcomes were observed to have lower levels of free triiodothyronine (fT3) and higher levels of SHR on admission. Medium values (fT3, 4.4 mmol/L; SHR, 8 nmol/L) were used to divide patients into four gradient stress degrees. Larger acute endocrine and metabolic variations (fT3 < 4.4 mmol/L and SHR ≥ 8 nmol/L) were independently associated with a poor one-year prognosis (adjusted OR = 4.231, P = 0.001)., High degrees of acute post-stroke stress may aggravate long-term ischemic stroke prognosis and timely stress-reduced interventions may help promote post-stroke living quality is equally important as survival.
ISSN	1471-2318
卷号	24 期号:1
DOI	10.1186/s12877-024-05453-9
收录类别	PUBMED
URL	查看原文
PubMed ID	39438798
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220983
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院附属第二医院第二临床医学院、附属第二医院、育英儿童医院第二临床医学院、附属第二医院、育英儿童医院_儿科学
作者单位	1.Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, 32500, Wenzhou, P R China.; 2.Department of Pediatrics, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, P R China.; 3.The first clinical medical college of Wenzhou Medical University, Wenzhou, P R China.; 4.Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, 32500, Wenzhou, P R China. dbinbin@aliyun.com.; 5.Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. dbinbin@aliyun.com.
第一作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chunyang Pang,Yufei Chen,Yinuo Chen,et al. What is the impact of acute endocrine and metabolic alterations on long-term ischemic stroke prognosis: a prospective study[J]. BMC geriatrics,2024,24(1).
APA	Chunyang Pang., Yufei Chen., Yinuo Chen., Er Lin., Xinnan Pan., ... & Binbin Deng. (2024). What is the impact of acute endocrine and metabolic alterations on long-term ischemic stroke prognosis: a prospective study. BMC geriatrics, 24(1).
MLA	Chunyang Pang,et al."What is the impact of acute endocrine and metabolic alterations on long-term ischemic stroke prognosis: a prospective study".BMC geriatrics 24.1(2024).