Fighting Amyotrophic Lateral Sclerosis by Protecting the Liver? A Prospective Cohort Study

doi:10.1002/ana.27115

科研成果详情

题名	Fighting Amyotrophic Lateral Sclerosis by Protecting the Liver? A Prospective Cohort Study
作者	Luyi Zhu1; Yaojia Li1; Xinyue Yu 2; Yinuo Chen 3; Junwei Zhang 1; Chunyang Pang1; Jiali Xie 1,4; Lingfei Gao1; Lihuai Du 5; Wen Cao 6; Dongsheng Fan 6; Can Cui 7; Huan Yu 8; Binbin Deng1
发表日期	2024-10-19
发表期刊	Annals of neurology 影响因子和分区
语种	英语
原始文献类型	Journal Article
摘要	Previous studies have observed liver abnormalities in amyotrophic lateral sclerosis (ALS) patients. This study aimed to investigate whether early signs of liver disease, measured by magnetic resonance imaging-derived iron-corrected T1-mapping (cT1), are risk factors for developing ALS., cT1 and proton density fat fraction were measured and automatically analyzed using LiverMultiScan® software. The Fibrosis-4 index was calculated using an established formula based on age and blood markers. Cox proportional hazard models were used to examine the relationship between liver disease, liver biomarkers, and incident ALS., In a cohort of 533,707 individuals from UK Biobank, 24 ALS cases were identified among 28,328 participants with liver disease during the follow-up period. Among a total of 33,959 individuals with complete liver imaging data, 15 incident ALS cases were observed during a median follow-up period of 5.6 years. Individuals with liver disease had a higher risk of developing ALS, with an adjusted hazard ratio of 7.35 (95% CI 4.47-12.09; p < 0.001). An increase in cT1 was also associated with a higher risk of ALS. After adjusting for age, sex, Townsend deprivation index, smoking status, alcohol intake frequency, body mass index, proton density fat fraction, Fibrosis-4, and metabolic syndrome, an increase in cT1 remained significantly associated with a higher risk of ALS, with an adjusted hazard ratio of 3.15 (95% CI 1.79-5.55) per 1-SD increase. Sensitivity analyses confirmed these robust results., Liver disease activity, indicated by cT1, increases the risk of developing ALS, independent of metabolic syndrome, liver fat, or fibrosis. ANN NEUROL 2024.
资助项目	National Natural Science Foundation of China[12101460];National Natural Science Foundation of China[81901273];Natural Science Foundation of Zhejiang Province[ZCLY24H0903]
ISSN	0364-5134
EISSN	1531-8249
DOI	10.1002/ana.27115
收录类别	PUBMED
URL	查看原文
PubMed ID	39425590
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220966
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院附属第二医院第二临床医学院、附属第二医院、育英儿童医院阿尔伯塔学院第二临床医学院、附属第二医院、育英儿童医院_儿科学
作者单位	1.Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; 2.Alberta Institute, Wenzhou Medical University, Wenzhou, China.; 3.First Clinical College of Wenzhou Medical University, Wenzhou, China.; 4.Department of Neurology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.; 5.College of Mathematics and Physics, Wenzhou University, Wenzhou, China.; 6.Department of Neurology, Peking University Third Hospital, Beijing, China.; 7.Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Solna, Sweden.; 8.Department of Pediatrics, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
第一作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Luyi Zhu,Yaojia Li,Xinyue Yu,et al. Fighting Amyotrophic Lateral Sclerosis by Protecting the Liver? A Prospective Cohort Study[J]. Annals of neurology,2024.
APA	Luyi Zhu., Yaojia Li., Xinyue Yu., Yinuo Chen., Junwei Zhang., ... & Binbin Deng. (2024). Fighting Amyotrophic Lateral Sclerosis by Protecting the Liver? A Prospective Cohort Study. Annals of neurology.
MLA	Luyi Zhu,et al."Fighting Amyotrophic Lateral Sclerosis by Protecting the Liver? A Prospective Cohort Study".Annals of neurology (2024).