Understanding myofibroblast origin in the fibrotic lung

doi:10.1016/j.pccm.2024.08.003

科研成果详情

题名	Understanding myofibroblast origin in the fibrotic lung
作者	Zabihi, Mahsa 1,2,3; Shahriari Felordi, Mahtab 1,2,3; Lingampally, Arun 1,2,3,4; Bellusci, Saverio 2,3,4,5; Chu, Xuran5; El Agha, Elie 1,2,3,5
发表日期	2024-09-01
发表期刊	Chinese Medical Journal Pulmonary and Critical Care Medicine 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Fibrotic disease Idiopathic pulmonary fibrosis Lineage tracing Myofibroblast heterogeneity Myofibroblasts
摘要	Idiopathic pulmonary fibrosis (IPF) is characterized by accumulation of myofibroblasts (MYFs) and extracellular matrix components, which leads to severe distortion and scarring of the gas exchange units of the lung, the alveoli, and ultimately respiratory failure. Fibrosis-associated MYFs are therefore widely regarded as the culprits that compromise the architectural makeup of the lung in fibrotic disease. During the past decade, the cellular source of MYFs has been intensely investigated. The rationale for such studies is that identifying the origin of these cells might help identify novel therapeutic targets and candidates to treat IPF patients. Recent advances in basic and translational research employing lineage tracing and multi-omics approaches have helped address the identity of MYF precursors, highlight the underlying heterogeneity, and to a less extent investigate MYF fate during fibrosis resolution. In this review, we discuss the current understanding of such important aspects of MYF biology as well as recent developments in the treatment of IPF.
资助项目	DFG[BE4443/6-1,BE 4443/1-1,CRC1213 268555672,KFO309 284237345 P7];CPI[EXC2026 390649896];Natural Science Foundation of Zhejiang[LQ24H210001,SFB CRC1213 268555672];
ISSN	2097-1982
EISSN	2772-5588
卷号	2 期号:3 页码:142-150
DOI	10.1016/j.pccm.2024.08.003
收录类别	SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-85204240531
通讯作者地址	[El Agha, Elie]Department of Medicine V,Internal Medicine,Infectious Diseases and Infection Control,Universities of Giessen and Marburg Lung Center (UGMLC),German Center for Lung Research (DZL),Justus-Liebig University Giessen,Giessen,Germany
Scopus学科分类	Critical Care and Intensive Care Medicine;Infectious Diseases;Pulmonary and Respiratory Medicine
SCOPUS_ID	SCOPUS_ID:85204240531
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220845
专题	药学院（分析测试中心）其他_瓯江实验室
通讯作者	El Agha, Elie
作者单位	1.Department of Medicine V,Internal Medicine,Infectious Diseases and Infection Control,Universities of Giessen and Marburg Lung Center (UGMLC),German Center for Lung Research (DZL),Justus-Liebig University Giessen,Giessen,35392,Germany; 2.Cardio-Pulmonary Institute (CPI),Giessen,35392,Germany; 3.Institute for Lung Health (ILH),Giessen,35392,Germany; 4.Department of Medicine II,Internal Medicine,Pulmonary and Critical Care,Universities of Giessen and Marburg Lung Center (UGMLC),German Center for Lung Research (DZL),Justus-Liebig University Giessen,Giessen,35392,Germany; 5.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),School of Pharmaceutical Science,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China
推荐引用方式 GB/T 7714	Zabihi, Mahsa,Shahriari Felordi, Mahtab,Lingampally, Arun,et al. Understanding myofibroblast origin in the fibrotic lung[J]. Chinese Medical Journal Pulmonary and Critical Care Medicine,2024,2(3):142-150.
APA	Zabihi, Mahsa, Shahriari Felordi, Mahtab, Lingampally, Arun, Bellusci, Saverio, Chu, Xuran, & El Agha, Elie. (2024). Understanding myofibroblast origin in the fibrotic lung. Chinese Medical Journal Pulmonary and Critical Care Medicine, 2(3), 142-150.
MLA	Zabihi, Mahsa,et al."Understanding myofibroblast origin in the fibrotic lung".Chinese Medical Journal Pulmonary and Critical Care Medicine 2.3(2024):142-150.