Synergic fabrication of combination drug-loaded niosomal nanoparticles: Deters cell proliferation induces apoptosis, alleviates oxidative stress in breast cancer cells

doi:10.1557/s43578-024-01438-x

科研成果详情

题名	Synergic fabrication of combination drug-loaded niosomal nanoparticles: Deters cell proliferation induces apoptosis, alleviates oxidative stress in breast cancer cells
作者	Yang, Han
发表日期	2024-09-23
发表期刊	JOURNAL OF MATERIALS RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Apoptosis Breast cancer Doxorubicin Drug delivery Methotrexate Niosomes Oxidative stress
其他关键词	DELIVERY ; COMPLEXES
摘要	This work examined the anticancer activity of Methotrexate (MTX) and Doxorubicin (DOX)-loaded niosomal decorated nanocarriers in vitro on MCF-7 and MDA-MB-231 breast cancer cells. A functionalised niosomal was designed to enhance endocytosis using folic acid (FA) and polyethylene glycol (PEG). Furthermore, cellular experiments showed that to DOX, MTX, and their combination (DOX and MTX), and DOX and MTX-loaded FA-PEGylated niosomal DOX and MTX (FPNDM) increased the apoptosis ratio (AO-EB, nuclear, PI and Annexin V-FITC, and PI staining) and cell scratch assay in MDA-MB-231 cells, respectively. FPNDM significantly reduced the levels of SOD, and CAT, increasing the levels of MDA-MB-231 cells, while FPNDM improved this milieu. We describe a niosome functionalised with FA and PEG loaded with DOX and MTX to treat breast cancer in this work for the first time. The findings showed that administering DOX and MTX using FA-PEGylated niosomes has enormous promise for treating breast cancer.Graphical AbstractDrug-loaded niosomal nanoparticles for breast cancer cells
资助项目	Basic Scientific Research Projects in Wenzhou City [2020Y0824]
出版者	SPRINGER HEIDELBERG
ISSN	0884-2914
EISSN	2044-5326
DOI	10.1557/s43578-024-01438-x
页数	18
WOS类目	Materials Science, Multidisciplinary
WOS研究方向	Materials Science
WOS记录号	WOS:001318266800002
收录类别	SCIE ; EI
EI入藏号	20243917096874
EI主题词	Cell death
EI分类号	102.1.1 ; 102.2.1 ; 103 ; 1301.4 ; 204.1 ; 761 Nanotechnology
通讯作者地址	[Yang, Han]Wenzhou Med Univ, Affiliated Hosp 1, Dept Oncol, Nanbaixiang St, Wenzhou 325000, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220817
专题	附属第一医院附属第一医院_肿瘤外科
通讯作者	Yang, Han
作者单位	Wenzhou Med Univ, Affiliated Hosp 1, Dept Oncol, Nanbaixiang St, Wenzhou 325000, Peoples R China
第一作者单位	附属第一医院; 肿瘤外科
通讯作者单位	附属第一医院; 肿瘤外科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Yang, Han. Synergic fabrication of combination drug-loaded niosomal nanoparticles: Deters cell proliferation induces apoptosis, alleviates oxidative stress in breast cancer cells[J]. JOURNAL OF MATERIALS RESEARCH,2024.
APA	Yang, Han. (2024). Synergic fabrication of combination drug-loaded niosomal nanoparticles: Deters cell proliferation induces apoptosis, alleviates oxidative stress in breast cancer cells. JOURNAL OF MATERIALS RESEARCH.
MLA	Yang, Han."Synergic fabrication of combination drug-loaded niosomal nanoparticles: Deters cell proliferation induces apoptosis, alleviates oxidative stress in breast cancer cells".JOURNAL OF MATERIALS RESEARCH (2024).