Role of Pyroptosis in Endometrial Cancer and Its Therapeutic Regulation

doi:10.2147/JIR.S486878

科研成果详情

题名	Role of Pyroptosis in Endometrial Cancer and Its Therapeutic Regulation
作者	Al Mamun, Abdullah 1,2; Geng, Peiwu1; Wang, Shuanghu1; Shao, Chuxiao1
发表日期	2024
发表期刊	JOURNAL OF INFLAMMATION RESEARCH 影响因子和分区
语种	英语
原始文献类型	Review
关键词	endometrial cancer pyroptosis NLRP3 caspase-1 GSDMD IL-1(3 IL-18
其他关键词	HYDROGEN-RICH WATER ; NONCANONICAL INFLAMMASOME ACTIVATION ; THIOREDOXIN-INTERACTING PROTEIN ; SPINAL-CORD-INJURY ; CELL-DEATH ; MOLECULAR-MECHANISMS ; GASDERMIN-D ; MACROPHAGE APOPTOSIS ; NLRP3 INFLAMMASOMES ; INDUCE PYROPTOSIS
摘要	Pyroptosis is an inflammatory cell death induced by inflammasomes that release several pro-inflammatory mediators such as interleukin-18 (IL-18) and interleukin-1 beta (IL-1 beta). Pyroptosis, a type of programmed cell death, has recently received increased interest both as a therapeutic and immunological mechanism. Numerous studies have provided substantial evidence supporting the involvement of inflammasomes and pyroptosis in a variety of pathological conditions including cancers, nerve damage, inflammatory diseases and metabolic conditions. Researchers have demonstrated that dysregulation of pyroptosis and inflammasomes contribute to the progression of endometriosis and gynecological malignancies. Current research also indicates that inflammasome and pyroptosisdependent signaling pathways may further induce the progression of endometrial cancer (EC). More specifically, dysregulation of NLR family pyrin domain 3 (NLRP3) and caspase-1-dependent pyroptosis play a contributory role in the pathogenesis and development of EC. Therefore, pyroptosis-regulated protein gasdermin D (GSDMD) may be an independent prognostic biomarker for the detection of EC. This review presents the molecular mechanisms of pyroptosis-dependent signaling pathways and their contributory role and function in advancing EC. Moreover, this review offers new insights into potential future applications and innovative approaches in utilizing pyroptosis to develop effective anti-cancer therapies.
资助项目	Key Research and Development Program of Zhejiang Province [2024C03171]; Key Research and Development Project of Lishui [2023zdyf15]; Public Welfare Technology Research Funding Project of Zhejiang [LTGY24H100002, LLSSY24H160003]; Zhejiang Provincial Medical and Health Science and Technology Project [2022RC302]; Post-Doctoral Research Start-Up Fund of Lishui People's Hospital, Lishui, Zhejiang, China [2023bsh001]
出版者	DOVE MEDICAL PRESS LTD
ISSN	1178-7031
EISSN	1178-7031
卷号	17 页码:7037-7056
DOI	10.2147/JIR.S486878
页数	20
WOS类目	Immunology
WOS研究方向	Immunology
WOS记录号	WOS:001330271400001
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	39377044
通讯作者地址	[Wang, Shuanghu;Shao, Chuxiao]Wenzhou Med Univ, Affiliated Hosp 1, Lishui Peoples Hosp, Lishui Hosp,Key Lab Joint Diag & Treatment Chron L, Lishui 323000, Zhejiang, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220795
专题	附属第一医院其他_附属第六医院（丽水市人民医院）
通讯作者	Wang, Shuanghu; Shao, Chuxiao
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Lishui Peoples Hosp, Lishui Hosp,Key Lab Joint Diag & Treatment Chron L, Lishui 323000, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Mol Pharmacol Res Ctr, Sch Pharmaceut Sci, Wenzhou 325000, Zhejiang, Peoples R China
第一作者单位	附属第一医院; 附属第六医院（丽水市人民医院）; 温州医科大学
通讯作者单位	附属第一医院; 附属第六医院（丽水市人民医院）
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Al Mamun, Abdullah,Geng, Peiwu,Wang, Shuanghu,et al. Role of Pyroptosis in Endometrial Cancer and Its Therapeutic Regulation[J]. JOURNAL OF INFLAMMATION RESEARCH,2024,17:7037-7056.
APA	Al Mamun, Abdullah, Geng, Peiwu, Wang, Shuanghu, & Shao, Chuxiao. (2024). Role of Pyroptosis in Endometrial Cancer and Its Therapeutic Regulation. JOURNAL OF INFLAMMATION RESEARCH, 17, 7037-7056.
MLA	Al Mamun, Abdullah,et al."Role of Pyroptosis in Endometrial Cancer and Its Therapeutic Regulation".JOURNAL OF INFLAMMATION RESEARCH 17(2024):7037-7056.