题名 | The co-expression of Crohn's disease and colon cancer network was analyzed by bioinformatics-CXCL1 tumour microenvironment and prognosis-related gene CXCL1 |
作者 | |
发表日期 | 2024-10-15 |
发表期刊 | Discover Oncology 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | Crohn's disease Colon cancer CXCL1 Microenvironment Inflammatory |
其他关键词 | NF-KAPPA-B ; INFLAMMATORY-BOWEL-DISEASE ; TNF ; EPIDEMIOLOGY ; PROGRESSION ; CHEMOKINES |
摘要 | PurposeThis study aimed to investigate the molecular links and mechanisms between Crohn's disease (CD) and colorectal cancer (CRC).MethodsThis study used the Gene Expression Omnibus (GEO) database to identify Differentially expressed genes (DEGs) in CD (GSE112366) and CRC (GSE110224), analyzed by 'edgeR' and 'limma'. The Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes explored DEG functions, and the Search Tool for the Retrieval of Interacting Genes (STRING) informed the protein-protein interaction network construction visualized in Cytoscape (version 3.7.2). Cyto-Hubba identified key genes, whose biomarker potential for CD and CRC was evaluated.ResultsThe study discovered 61 DEGs, with 44 up- and 17 down-regulated, linked to immune responses and signaling pathways. CXCL1, highly expressed in colon cancer, correlated with better prognosis and lower staging. It also showed associations with immune infiltration and checkpoint molecules, suggesting a role in cancer progression and retreat.ConclusionCXCL1 may play a role in the development of colorectal cancer from inflammatory bowel disease. |
资助项目 | Natural Science Foundation of Zhejiang Province [LY21H280012]; Beijing Science and Technology Innovation Medical Development Foundation; Program of Zhejiang Provincial TCM Sci-tech Plan [2023ZL506] |
出版者 | SPRINGER |
ISSN | 2730-6011 |
EISSN | 2730-6011 |
卷号 | 15期号:1 |
DOI | 10.1007/s12672-024-01423-0 |
页数 | 15 |
WOS类目 | Oncology ; Endocrinology & Metabolism |
WOS研究方向 | Oncology ; Endocrinology & Metabolism |
WOS记录号 | WOS:001331234400001 |
收录类别 | SCIE ; SCOPUS ; PUBMED |
URL | 查看原文 |
PubMed ID | 39402186 |
SCOPUSEID | 2-s2.0-85206388227 |
通讯作者地址 | [Fei, Zhenghua]Wenzhou Med Univ, Affiliated Hosp 1, Dept Radiotherapy, Wenzhou 325000, Peoples R China. ; [Xu, Yangjie]Wenzhou Med Univ, Affiliated Cixi Hosp, Dept Oncol, Ningbo, Peoples R China. |
Scopus学科分类 | Endocrinology, Diabetes and Metabolism;Oncology;Endocrinology;Endocrine and Autonomic Systems;Cancer Research |
SCOPUS_ID | SCOPUS_ID:85206388227 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/220738 |
专题 | 附属第一医院 附属第一医院_放化疗科 其他_温州市第三临床学院(温州市人民医院) 其他_附属第三医院(瑞安市人民医院) 其他_附属慈溪医院(慈溪市人民医院) |
通讯作者 | Xu, Yangjie; Fei, Zhenghua |
作者单位 | 1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Radiotherapy, Wenzhou 325000, Peoples R China; 2.Jiaxing Univ, Affiliated Hosp 1, Dept Oncol, 1882 Zhonghuan South Rd, Jiaxing 314000, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 3, Ruian Peoples Hosp, Dept Med Oncol, 108 Wansong Rd, Ruian 325200, Peoples R China; 4.Wenzhou Med Univ, Affiliated Cixi Hosp, Dept Oncol, Ningbo, Peoples R China |
第一作者单位 | 附属第一医院; 放化疗科 |
通讯作者单位 | 附属第一医院; 放化疗科; 附属慈溪医院(慈溪市人民医院) |
第一作者的第一单位 | 附属第一医院 |
推荐引用方式 GB/T 7714 | Mao, Zijuan,Gu, Yuyang,Tao, Ganxue,et al. The co-expression of Crohn's disease and colon cancer network was analyzed by bioinformatics-CXCL1 tumour microenvironment and prognosis-related gene CXCL1[J]. Discover Oncology,2024,15(1). |
APA | Mao, Zijuan, Gu, Yuyang, Tao, Ganxue, Dai, Qiang, Xu, Yangjie, & Fei, Zhenghua. (2024). The co-expression of Crohn's disease and colon cancer network was analyzed by bioinformatics-CXCL1 tumour microenvironment and prognosis-related gene CXCL1. Discover Oncology, 15(1). |
MLA | Mao, Zijuan,et al."The co-expression of Crohn's disease and colon cancer network was analyzed by bioinformatics-CXCL1 tumour microenvironment and prognosis-related gene CXCL1".Discover Oncology 15.1(2024). |
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