科研成果详情

题名The co-expression of Crohn's disease and colon cancer network was analyzed by bioinformatics-CXCL1 tumour microenvironment and prognosis-related gene CXCL1
作者
发表日期2024-10-15
发表期刊Discover Oncology   影响因子和分区
语种英语
原始文献类型Article
关键词Crohn's disease Colon cancer CXCL1 Microenvironment Inflammatory
其他关键词NF-KAPPA-B ; INFLAMMATORY-BOWEL-DISEASE ; TNF ; EPIDEMIOLOGY ; PROGRESSION ; CHEMOKINES
摘要PurposeThis study aimed to investigate the molecular links and mechanisms between Crohn's disease (CD) and colorectal cancer (CRC).MethodsThis study used the Gene Expression Omnibus (GEO) database to identify Differentially expressed genes (DEGs) in CD (GSE112366) and CRC (GSE110224), analyzed by 'edgeR' and 'limma'. The Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes explored DEG functions, and the Search Tool for the Retrieval of Interacting Genes (STRING) informed the protein-protein interaction network construction visualized in Cytoscape (version 3.7.2). Cyto-Hubba identified key genes, whose biomarker potential for CD and CRC was evaluated.ResultsThe study discovered 61 DEGs, with 44 up- and 17 down-regulated, linked to immune responses and signaling pathways. CXCL1, highly expressed in colon cancer, correlated with better prognosis and lower staging. It also showed associations with immune infiltration and checkpoint molecules, suggesting a role in cancer progression and retreat.ConclusionCXCL1 may play a role in the development of colorectal cancer from inflammatory bowel disease.
资助项目Natural Science Foundation of Zhejiang Province [LY21H280012]; Beijing Science and Technology Innovation Medical Development Foundation; Program of Zhejiang Provincial TCM Sci-tech Plan [2023ZL506]
出版者SPRINGER
ISSN2730-6011
EISSN2730-6011
卷号15期号:1
DOI10.1007/s12672-024-01423-0
页数15
WOS类目Oncology ; Endocrinology & Metabolism
WOS研究方向Oncology ; Endocrinology & Metabolism
WOS记录号WOS:001331234400001
收录类别SCIE ; SCOPUS ; PUBMED
URL查看原文
PubMed ID39402186
SCOPUSEID2-s2.0-85206388227
通讯作者地址[Fei, Zhenghua]Wenzhou Med Univ, Affiliated Hosp 1, Dept Radiotherapy, Wenzhou 325000, Peoples R China. ; [Xu, Yangjie]Wenzhou Med Univ, Affiliated Cixi Hosp, Dept Oncol, Ningbo, Peoples R China.
Scopus学科分类Endocrinology, Diabetes and Metabolism;Oncology;Endocrinology;Endocrine and Autonomic Systems;Cancer Research
SCOPUS_IDSCOPUS_ID:85206388227
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/220738
专题附属第一医院
附属第一医院_放化疗科
其他_温州市第三临床学院(温州市人民医院)
其他_附属第三医院(瑞安市人民医院)
其他_附属慈溪医院(慈溪市人民医院)
通讯作者Xu, Yangjie; Fei, Zhenghua
作者单位
1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Radiotherapy, Wenzhou 325000, Peoples R China;
2.Jiaxing Univ, Affiliated Hosp 1, Dept Oncol, 1882 Zhonghuan South Rd, Jiaxing 314000, Zhejiang, Peoples R China;
3.Wenzhou Med Univ, Affiliated Hosp 3, Ruian Peoples Hosp, Dept Med Oncol, 108 Wansong Rd, Ruian 325200, Peoples R China;
4.Wenzhou Med Univ, Affiliated Cixi Hosp, Dept Oncol, Ningbo, Peoples R China
第一作者单位附属第一医院;  放化疗科
通讯作者单位附属第一医院;  放化疗科;  附属慈溪医院(慈溪市人民医院)
第一作者的第一单位附属第一医院
推荐引用方式
GB/T 7714
Mao, Zijuan,Gu, Yuyang,Tao, Ganxue,et al. The co-expression of Crohn's disease and colon cancer network was analyzed by bioinformatics-CXCL1 tumour microenvironment and prognosis-related gene CXCL1[J]. Discover Oncology,2024,15(1).
APA Mao, Zijuan, Gu, Yuyang, Tao, Ganxue, Dai, Qiang, Xu, Yangjie, & Fei, Zhenghua. (2024). The co-expression of Crohn's disease and colon cancer network was analyzed by bioinformatics-CXCL1 tumour microenvironment and prognosis-related gene CXCL1. Discover Oncology, 15(1).
MLA Mao, Zijuan,et al."The co-expression of Crohn's disease and colon cancer network was analyzed by bioinformatics-CXCL1 tumour microenvironment and prognosis-related gene CXCL1".Discover Oncology 15.1(2024).

条目包含的文件

条目无相关文件。
个性服务
查看访问统计
谷歌学术
谷歌学术中相似的文章
[Mao, Zijuan]的文章
[Gu, Yuyang]的文章
[Tao, Ganxue]的文章
百度学术
百度学术中相似的文章
[Mao, Zijuan]的文章
[Gu, Yuyang]的文章
[Tao, Ganxue]的文章
必应学术
必应学术中相似的文章
[Mao, Zijuan]的文章
[Gu, Yuyang]的文章
[Tao, Ganxue]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。