Association between liver fibrosis and the in-hospital mortality in patients with sepsis-induced coagulopathy

doi:10.1186/s12879-024-10051-6

科研成果详情

题名	Association between liver fibrosis and the in-hospital mortality in patients with sepsis-induced coagulopathy
作者	Shi, Yiyi 1; Meng, Zhizhen 2; Qian, Songzan3,6; Zheng, Rui 4; Lou, Chen 5; Pan, Jingye3,6
发表日期	2024-10-10
发表期刊	BMC Infectious Diseases 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Liver fibrosis Sepsis-induced coagulopathy In-hospital mortality Fibrosis-4 score NFS
其他关键词	OUTCOMES ; DISEASE ; SCORE
摘要	BackgroundThe impact of liver fibrosis on the clinical outcomes of patients with sepsis-induced coagulopathy (SIC) is not well understood. This study aimed to evaluate the association between liver fibrosis scores and in-hospital mortality in SIC patients.MethodsIn this retrospective observational cohort study, data were collected from patients diagnosed with sepsis and admitted to the ICU at the First Affiliated Hospital of Wenzhou Medical University between January 2017 and December 2023. Liver fibrosis was evaluated using three scores: Fibrosis-4 (Fib-4), Aspartate Aminotransferase-to-Platelet Ratio Index (APRI), and Nonalcoholic Fatty Liver Disease Fibrosis Score (NFS). Patients were divided into tertiles according to their liver fibrosis scores, and the primary outcome was in-hospital mortality. Multivariable logistic regression and restricted cubic spline regression analyses were used to assess associations, complemented by sensitivity analyses through subgroup evaluations.ResultsThe cohort included 948 patients diagnosed with SIC with an in-hospital mortality of 26.16%. Multivariate logistic regression analysis revealed a significant association between higher liver fibrosis scores and increased in-hospital mortality. Specifically, patients in the highest tertile of Fib-4, APRI, and NFS scores had significantly higher odds of mortality (FIB-4: OR 3.62, 95% CI 1.03-12.69; APRI: OR 2.16, 95% CI 0.88-5.30; NFS: OR 6.80, 95% CI 2.11-21.93) compared to those in the lowest tertile. The restricted cubic spline regression model showed a linear increase in the risk of in-hospital mortality with increasing liver fibrosis score. Sensitivity analysis confirmed the consistency and stability of the results across the different subgroups.ConclusionOur study suggests that elevated liver fibrosis scores, particularly Fib-4 and NFS, are associated with higher in-hospital mortality in SIC patients. Further research, especially larger prospective studies, are needed to validate these findings.
资助项目	Foundation of Wenzhou City Science & Technology Bureau [Y20240164, Y20210713]; Wenzhou major science and technology innovation project [ZY2023005]; Key Clinical Specialty of Zhejiang Province (Critical Care MedicineY)
出版者	BMC
ISSN	1471-2334
EISSN	1471-2334
卷号	24 期号:1
DOI	10.1186/s12879-024-10051-6
页数	10
WOS类目	Infectious Diseases
WOS研究方向	Infectious Diseases
WOS记录号	WOS:001336898200002
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	39390403
SCOPUSEID	2-s2.0-85206057733
通讯作者地址	[Pan, Jingye]Wenzhou Med Univ, Affiliated Hosp 1, Dept Intens Care Unit, Wenzhou 325000, Peoples R China. ; [Pan, Jingye]Zhejiang Key Lab crit care Med, Wenzhou, Peoples R China.
Scopus学科分类	Infectious Diseases
SCOPUS_ID	SCOPUS_ID:85206057733
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220709
专题	附属第一医院_麻醉科第一临床医学院（信息与工程学院）、附属第一医院附属第一医院_重症医学科（ICU）
通讯作者	Pan, Jingye
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Wenzhou 325000, Peoples R China; 2.Zhejiang Univ, Affiliated Hosp 4, Dept Emergency, Sch Med, Hangzhou, Yiwu, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 1, Dept Intens Care Unit, Wenzhou 325000, Peoples R China; 4.Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Crit Care Med, Hangzhou 310016, Zhejiang, Peoples R China; 5.Wenzhou Med Univ, Sch Clin Med Sci 1, Wenzhou 325000, Peoples R China; 6.Zhejiang Key Lab crit care Med, Wenzhou, Peoples R China
第一作者单位	附属第一医院_麻醉科
通讯作者单位	附属第一医院_重症医学科（ICU）
第一作者的第一单位	附属第一医院_麻醉科
推荐引用方式 GB/T 7714	Shi, Yiyi,Meng, Zhizhen,Qian, Songzan,et al. Association between liver fibrosis and the in-hospital mortality in patients with sepsis-induced coagulopathy[J]. BMC Infectious Diseases,2024,24(1).
APA	Shi, Yiyi, Meng, Zhizhen, Qian, Songzan, Zheng, Rui, Lou, Chen, & Pan, Jingye. (2024). Association between liver fibrosis and the in-hospital mortality in patients with sepsis-induced coagulopathy. BMC Infectious Diseases, 24(1).
MLA	Shi, Yiyi,et al."Association between liver fibrosis and the in-hospital mortality in patients with sepsis-induced coagulopathy".BMC Infectious Diseases 24.1(2024).