Unleashing the Power of Cold Atmospheric Plasma: Inducing Mitochondria Damage-Mediated Mitotic Catastrophe

doi:10.1002/advs.202401842

科研成果详情

题名	Unleashing the Power of Cold Atmospheric Plasma: Inducing Mitochondria Damage-Mediated Mitotic Catastrophe
作者	Peng, Shengjie 1,2; Feng, Yue 1,3; Yu, K. N.4,5; Wu, Lijun 6; Chen, Guodong 1,7; Yang, Miaomiao 1,2; Zhao, Lele 1,3; Cao, Wei 1; Cui, Qianwen 1,2; Chen, Lianjun 8; Li, Quan9; Huang, Yifan 2; Cheng, Cheng 10; Zhu, Fengqin 7; Han, Wei 1,4,7,11,12
发表日期	2024-10-23
发表期刊	ADVANCED SCIENCE 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	anti-tumor effect cold atmospheric plasma mitochondria damage mitotic catastrophe
其他关键词	HOMEOSTASIS ; SENESCENCE ; DEATH ; LINK
摘要	Despite the promise of cold atmospheric plasma (CAP) for cancer treatment, the challenges associated with the treatment of solid tumors and penetration depth limitations remain, restricting its clinical application. Here, biological evidence is provided that the killing effect of CAP treatment is confined to less than 500 mu m subcutaneously and the actual biological dose decreased gradually with depth for the first time, indicating that the limited penetration depth has become an urgent problem that demands immediate solutions. Significantly, it is showed that different from high-dose treatments, CAP decreased the doses to the low-dose range but still exhibited anti-tumor effects via mitotic catastrophe. Unlike radiotherapy or chemotherapy, low-dose CAP treatment induces mitochondrial structural damage and dysfunction, disrupts energy metabolism and redox balance, and results in mitotic catastrophe. Collectively, these findings suggest that better understanding and taking full advantage of the dose-response gradient effect of CAP is a potential strategy to prompt its clinical application beyond improving CAP penetration. This study focuses on the limited cold atmospheric plasma (CAP) penetration, a major challenge for its clinical application, in vivo and the results show the depth-dependent biological effect of CAP treatment for the first time. Mitochondria damage and dysfunction induced by low dose CAP suppress microtubule assemble and spindle bipolar, and ultimately result in mitotic catastrophe to suppress tumor growth. image
资助项目	Chinese National Natural Science Foundation; Key Research and Development Project of Anhui Province [202104j07020009]; Hefei Comprehensive National Science Center; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD); Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection [9220124, 9229151]; City University of Hong Kong; [U20A20372]; [81974484]
出版者	WILEY
ISSN	2198-3844
EISSN	2198-3844
DOI	10.1002/advs.202401842
页数	14
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:001338259900001
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	39440523
通讯作者地址	[Han, Wei]Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China. ; [Han, Wei]City Univ Hong Kong, Dept Phys, Kowloon Tong, Tat Chee Ave, Hong Kong, Peoples R China. ; [Han, Wei]Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China. ; [Han, Wei]Soochow Univ, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst, Suzhou 215006, Peoples R China. ; [Han, Wei]Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215006, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/220608
专题	公共卫生学院公共卫生学院_放射卫生与放射医学系
通讯作者	Han, Wei
作者单位	1.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China; 2.Univ Sci & Technol China, Hefei 230026, Peoples R China; 3.Anhui Med Univ, Sch Basic Med Sci, Teaching & Res Sect Nucl Med, Hefei 230032, Peoples R China; 4.City Univ Hong Kong, Dept Phys, Kowloon Tong, Tat Chee Ave, Hong Kong, Peoples R China; 5.City Univ Hong Kong, State Key Lab Marine Pollut, Kowloon Tong, Tat Chee Ave, Hong Kong, Peoples R China; 6.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230031, Peoples R China; 7.Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China; 8.Hefei Univ, Sch Biol Food & Environm, Hefei 230601, Peoples R China; 9.Wenzhou Med Univ, Sch Publ Hlth & Management, Dept Radiat Med, Wenzhou 325035, Peoples R China; 10.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Plasma Phys, Hefei 230031, Peoples R China; 11.Soochow Univ, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst, Suzhou 215006, Peoples R China; 12.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215006, Peoples R China
推荐引用方式 GB/T 7714	Peng, Shengjie,Feng, Yue,Yu, K. N.,et al. Unleashing the Power of Cold Atmospheric Plasma: Inducing Mitochondria Damage-Mediated Mitotic Catastrophe[J]. ADVANCED SCIENCE,2024.
APA	Peng, Shengjie., Feng, Yue., Yu, K. N.., Wu, Lijun., Chen, Guodong., ... & Han, Wei. (2024). Unleashing the Power of Cold Atmospheric Plasma: Inducing Mitochondria Damage-Mediated Mitotic Catastrophe. ADVANCED SCIENCE.
MLA	Peng, Shengjie,et al."Unleashing the Power of Cold Atmospheric Plasma: Inducing Mitochondria Damage-Mediated Mitotic Catastrophe".ADVANCED SCIENCE (2024).