Delayed Surgical Reversal of Optic Nerve Compression Leads to Exponential Degeneration of Optic Nerve Fibers and Selective Sparing of the Small Fibers

doi:10.1167/iovs.65.11.40

科研成果详情

题名	Delayed Surgical Reversal of Optic Nerve Compression Leads to Exponential Degeneration of Optic Nerve Fibers and Selective Sparing of the Small Fibers
作者	XiaoHui Jiang; Boyue Xu; Shuang Yao; Zhuowei Wang; Mingyue Liu; Yikui Zhang; Wencan Wu; Ende Wu
发表日期	2024-09-03
发表期刊	Investigative Ophthalmology and Visual Science 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	compressive optic neuropathy optic nerve ganglion cell complex rabbit decompression
其他关键词	AXONAL-TRANSPORT ; GANGLION-CELLS ; GLAUCOMA ; DECOMPRESSION ; NEUROPATHY ; SURGERY ; MENINGIOMAS ; RECOVERY
摘要	To evaluate the effectiveness of surgical reversal of experimental optic nerve compression in treating persistent compressive optic neuropathy and to explore the relationship between surgical outcomes and the timing of the procedure., Surgical reversal procedures (decompression surgery) were conducted at five time intervals: 1, 3, and 7 days and 2 and 3 weeks following optic nerve compression in a rabbit model. The groups were labeled as DC-1d, DC-3d, DC-7d, DC-2w, and DC-3w, respectively. The study investigated changes in ganglion cell complex (GCC) thickness using spectral-domain optical coherence tomography and the percentage of surviving retinal ganglion cells (RGCs) through immunofluorescence staining and optic nerve axons stained with p-phenylenediamine at 4 weeks after decompression. Additionally, the area distribution of surviving axons was analyzed., The decline in GCC thickness was halted following decompression. The remaining thickness of the GCC in group DC-1d was found to be statistically significantly higher at 2, 3, and 4 weeks postonset compared to the no-decompression group. Similarly, GCC thickness in group DC-3d was significantly higher at 3 and 4 weeks postonset. The percentage of surviving RGCs and axons at 4 weeks postonset exhibited an exponential correlation with the onset time of decompression, with R2 values of 0.72 and 0.78, respectively. The surviving axon area declined following delayed decompression., Persistent substantial compression on the optic nerve leads to exponential degeneration of the optic nerve, initially affecting larger optic nerve fibers. Early intervention aimed at relieving the compression on the optic nerve may offer potential benefits in mitigating the degenerative effects and conserving visual function.
资助项目	National Key Research and Development Program of China [2021YFA1101200]
出版者	ASSOC RESEARCH VISION OPHTHALMOLOGY INC
ISSN	0146-0404
EISSN	1552-5783
卷号	65 期号:11
DOI	10.1167/iovs.65.11.40
页数	9
WOS类目	Ophthalmology
WOS研究方向	Ophthalmology
WOS记录号	WOS:001334690700006
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	39325469
SCOPUSEID	2-s2.0-85204941946
通讯作者地址	[Wu, Wencan;Wu, Ende]Wenzhou Med Univ, Eye Hosp, Natl Clin Res Ctr Ocular Dis, Wenzhou 325027, Peoples R China.
Scopus学科分类	Ophthalmology;Sensory Systems;Cellular and Molecular Neuroscience
SCOPUS_ID	SCOPUS_ID:85204941946
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218973
专题	眼视光学院（生物医学工程学院）、附属眼视光医院眼视光学院（生物医学工程学院）、附属眼视光医院_眼鼻相关及眼眶眼肿瘤专科
作者单位	National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
第一作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
第一作者的第一单位	眼视光学院（生物医学工程学院）、附属眼视光医院
推荐引用方式 GB/T 7714	XiaoHui Jiang,Boyue Xu,Shuang Yao,et al. Delayed Surgical Reversal of Optic Nerve Compression Leads to Exponential Degeneration of Optic Nerve Fibers and Selective Sparing of the Small Fibers[J]. Investigative Ophthalmology and Visual Science,2024,65(11).
APA	XiaoHui Jiang., Boyue Xu., Shuang Yao., Zhuowei Wang., Mingyue Liu., ... & Ende Wu. (2024). Delayed Surgical Reversal of Optic Nerve Compression Leads to Exponential Degeneration of Optic Nerve Fibers and Selective Sparing of the Small Fibers. Investigative Ophthalmology and Visual Science, 65(11).
MLA	XiaoHui Jiang,et al."Delayed Surgical Reversal of Optic Nerve Compression Leads to Exponential Degeneration of Optic Nerve Fibers and Selective Sparing of the Small Fibers".Investigative Ophthalmology and Visual Science 65.11(2024).