Comparative analysis of Paiteling a traditional Chinese medicine (TCM) and CO2 laser therapy for high-risk HPV-associated with LSIL (CIN1) lesions

doi:10.1016/j.ejogrb.2024.08.042

科研成果详情

题名	Comparative analysis of Paiteling a traditional Chinese medicine (TCM) and CO2 laser therapy for high-risk HPV-associated with LSIL (CIN1) lesions
作者	Cobbinah, Portia 1; Zheng, Shi Zheng 1; Oklah, Francis 2; Yuyang, Zhang 1
发表日期	2024-11
发表期刊	European Journal of Obstetrics and Gynecology and Reproductive Biology 影响因子和分区
语种	英语
原始文献类型	Article
关键词	LSIL (CIN 1) CO2 laser therapy Paiteling High-risk human papillomavirus (HR-HPV) Chinese traditional medicine
其他关键词	HUMAN-PAPILLOMAVIRUS INFECTION ; PREVALENCE
摘要	Objectives: This study aims to evaluate the therapeutic outcomes of Paiteling and CO2 laser therapy on high-risk human papillomavirus. Methods: We retrospectively analyzed the data of 558 patients with HR-HPV low-grade squamous intraepithelial neoplasia (CIN1) from 2021 to 2023. Patients were selected and put into two groups: Paiteling and CO2 laser. Out of the 558 patients who were included in our final study, 239 (42.8 %) were treated with Paiteling, and 319 (57.2 %) were treated with CO2 laser vaporization. The mean age was 49.55 +/- 12.10 years old. We observed that 27 (4.83 %) were younger than 30 years and 531 (95.1 %) were older than 30 years. We reviewed the patient's results at intervals of 3 months, 6 months, 12 months, and 24 months after each therapy. The results of the recurrence rate, effective viral clearance rate, and the effectiveness of both therapies on low-grade cervical lesions were determined using multivariate and univariate cox-regression analysis. The Kaplan-Meier curve was used to determine the HR-HPV conversion rate of each therapy. Results: The median time for HR-HPV clearance was 6.00 months (95 % CI: 4.26-6.89) in the Paiteling group and 9.00 months (95 % CI: 15.92-22.67) in the CO2 laser group. There was a significant difference between the two groups (chi(2) = 25.118, p-Value = 0.000). The HR-HPV clearance rate during 6-12 months for Paiteling and CO2 laser was 100 (55.6 %) and 80 (44.4 %), respectively. The clearance rate for both therapies from 6 to 18 months was statistically significant (6-12 months: p < 0.010, 12-18 months: p < 0.011). The Paiteling HR-HPV negative rate over 24 months 214 (89.5 %) is higher than CO2 laser 176 (55.2 %). Paiteling has a 5.4 % re-infection rate, which is marginally lower than the 5.6 % rate for CO2 lasers. The clearance rate for both therapies from 12 to 18 months [Paiteling: 20 (4.7 %) to 10 (3.6 %) and CO2 laser: 22 (8.4 %) to 15 (4.2 %)] was also significant (p < 0.011). The percentage of persistent Hr-HPV clearance rate for Paiteling patients was higher than carbon dioxide laser vaporization. No severe side effects were reported by the Paiteling patients compared to laser vaporization. This is due to the fact that Paiteling, as a traditional Chinese medicine, is a topical, non-invasive medicine, thus preserving the integrity of the cervix. Conclusions: Paiteling is an effective noninvasive therapy that can clear persistent HR-HPV associated with cervical low-grade squamous lesions in a relatively shorter period of time compared to CO2 laser ablation.
资助项目	Wenzhou Science and Technology Planning Project [Y20140695]; Natural Science Foundation of Zhejiang Province [LY18C010003]
出版者	ELSEVIER
ISSN	0301-2115
EISSN	1872-7654
卷号	302 页码:81-86
DOI	10.1016/j.ejogrb.2024.08.042
页数	6
WOS类目	Obstetrics & Gynecology ; Reproductive Biology
WOS研究方向	Obstetrics & Gynecology ; Reproductive Biology
WOS记录号	WOS:001309512700001
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	39236645
SCOPUSEID	2-s2.0-85202996406
通讯作者地址	[Zheng, Shi Zheng;Yuyang, Zhang]Wenzhou Med Univ, Affiliated Hosp 1, Dept Gynecol, Ouhai 325003, Zhejiang, Peoples R China.
Scopus学科分类	Reproductive Medicine;Obstetrics and Gynecology
SCOPUS_ID	SCOPUS_ID:85202996406
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218717
专题	附属第一医院附属第一医院_妇科
通讯作者	Zheng, Shi Zheng; Yuyang, Zhang
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Gynecol, Ouhai 325003, Zhejiang, Peoples R China; 2.Ho Teaching Hosp, Ho, Volta Region, Ghana
第一作者单位	附属第一医院; 妇科
通讯作者单位	附属第一医院; 妇科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Cobbinah, Portia,Zheng, Shi Zheng,Oklah, Francis,et al. Comparative analysis of Paiteling a traditional Chinese medicine (TCM) and CO2 laser therapy for high-risk HPV-associated with LSIL (CIN1) lesions[J]. European Journal of Obstetrics and Gynecology and Reproductive Biology,2024,302:81-86.
APA	Cobbinah, Portia, Zheng, Shi Zheng, Oklah, Francis, & Yuyang, Zhang. (2024). Comparative analysis of Paiteling a traditional Chinese medicine (TCM) and CO2 laser therapy for high-risk HPV-associated with LSIL (CIN1) lesions. European Journal of Obstetrics and Gynecology and Reproductive Biology, 302, 81-86.
MLA	Cobbinah, Portia,et al."Comparative analysis of Paiteling a traditional Chinese medicine (TCM) and CO2 laser therapy for high-risk HPV-associated with LSIL (CIN1) lesions".European Journal of Obstetrics and Gynecology and Reproductive Biology 302(2024):81-86.