题名 | Comparative analysis of Paiteling a traditional Chinese medicine (TCM) and CO2 laser therapy for high-risk HPV-associated with LSIL (CIN1) lesions |
作者 | |
发表日期 | 2024-11 |
发表期刊 | European Journal of Obstetrics and Gynecology and Reproductive Biology 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | LSIL (CIN 1) CO2 laser therapy Paiteling High-risk human papillomavirus (HR-HPV) Chinese traditional medicine |
其他关键词 | HUMAN-PAPILLOMAVIRUS INFECTION ; PREVALENCE |
摘要 | Objectives: This study aims to evaluate the therapeutic outcomes of Paiteling and CO2 laser therapy on high-risk human papillomavirus. Methods: We retrospectively analyzed the data of 558 patients with HR-HPV low-grade squamous intraepithelial neoplasia (CIN1) from 2021 to 2023. Patients were selected and put into two groups: Paiteling and CO2 laser. Out of the 558 patients who were included in our final study, 239 (42.8 %) were treated with Paiteling, and 319 (57.2 %) were treated with CO2 laser vaporization. The mean age was 49.55 +/- 12.10 years old. We observed that 27 (4.83 %) were younger than 30 years and 531 (95.1 %) were older than 30 years. We reviewed the patient's results at intervals of 3 months, 6 months, 12 months, and 24 months after each therapy. The results of the recurrence rate, effective viral clearance rate, and the effectiveness of both therapies on low-grade cervical lesions were determined using multivariate and univariate cox-regression analysis. The Kaplan-Meier curve was used to determine the HR-HPV conversion rate of each therapy. Results: The median time for HR-HPV clearance was 6.00 months (95 % CI: 4.26-6.89) in the Paiteling group and 9.00 months (95 % CI: 15.92-22.67) in the CO2 laser group. There was a significant difference between the two groups (chi(2) = 25.118, p-Value = 0.000). The HR-HPV clearance rate during 6-12 months for Paiteling and CO2 laser was 100 (55.6 %) and 80 (44.4 %), respectively. The clearance rate for both therapies from 6 to 18 months was statistically significant (6-12 months: p < 0.010, 12-18 months: p < 0.011). The Paiteling HR-HPV negative rate over 24 months 214 (89.5 %) is higher than CO2 laser 176 (55.2 %). Paiteling has a 5.4 % re-infection rate, which is marginally lower than the 5.6 % rate for CO2 lasers. The clearance rate for both therapies from 12 to 18 months [Paiteling: 20 (4.7 %) to 10 (3.6 %) and CO2 laser: 22 (8.4 %) to 15 (4.2 %)] was also significant (p < 0.011). The percentage of persistent Hr-HPV clearance rate for Paiteling patients was higher than carbon dioxide laser vaporization. No severe side effects were reported by the Paiteling patients compared to laser vaporization. This is due to the fact that Paiteling, as a traditional Chinese medicine, is a topical, non-invasive medicine, thus preserving the integrity of the cervix. Conclusions: Paiteling is an effective noninvasive therapy that can clear persistent HR-HPV associated with cervical low-grade squamous lesions in a relatively shorter period of time compared to CO2 laser ablation. |
资助项目 | Wenzhou Science and Technology Planning Project [Y20140695]; Natural Science Foundation of Zhejiang Province [LY18C010003] |
出版者 | ELSEVIER |
ISSN | 0301-2115 |
EISSN | 1872-7654 |
卷号 | 302页码:81-86 |
DOI | 10.1016/j.ejogrb.2024.08.042 |
页数 | 6 |
WOS类目 | Obstetrics & Gynecology ; Reproductive Biology |
WOS研究方向 | Obstetrics & Gynecology ; Reproductive Biology |
WOS记录号 | WOS:001309512700001 |
收录类别 | SCIE ; SCOPUS |
URL | 查看原文 |
PubMed ID | 39236645 |
SCOPUSEID | 2-s2.0-85202996406 |
通讯作者地址 | [Zheng, Shi Zheng;Yuyang, Zhang]Wenzhou Med Univ, Affiliated Hosp 1, Dept Gynecol, Ouhai 325003, Zhejiang, Peoples R China. |
Scopus学科分类 | Reproductive Medicine;Obstetrics and Gynecology |
SCOPUS_ID | SCOPUS_ID:85202996406 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/218717 |
专题 | 附属第一医院 附属第一医院_妇科 |
通讯作者 | Zheng, Shi Zheng; Yuyang, Zhang |
作者单位 | 1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Gynecol, Ouhai 325003, Zhejiang, Peoples R China; 2.Ho Teaching Hosp, Ho, Volta Region, Ghana |
第一作者单位 | 附属第一医院; 妇科 |
通讯作者单位 | 附属第一医院; 妇科 |
第一作者的第一单位 | 附属第一医院 |
推荐引用方式 GB/T 7714 | Cobbinah, Portia,Zheng, Shi Zheng,Oklah, Francis,et al. Comparative analysis of Paiteling a traditional Chinese medicine (TCM) and CO2 laser therapy for high-risk HPV-associated with LSIL (CIN1) lesions[J]. European Journal of Obstetrics and Gynecology and Reproductive Biology,2024,302:81-86. |
APA | Cobbinah, Portia, Zheng, Shi Zheng, Oklah, Francis, & Yuyang, Zhang. (2024). Comparative analysis of Paiteling a traditional Chinese medicine (TCM) and CO2 laser therapy for high-risk HPV-associated with LSIL (CIN1) lesions. European Journal of Obstetrics and Gynecology and Reproductive Biology, 302, 81-86. |
MLA | Cobbinah, Portia,et al."Comparative analysis of Paiteling a traditional Chinese medicine (TCM) and CO2 laser therapy for high-risk HPV-associated with LSIL (CIN1) lesions".European Journal of Obstetrics and Gynecology and Reproductive Biology 302(2024):81-86. |
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