题名 | NLRP1 inhibits lung adenocarcinoma growth through mediating mitochondrial dysregulation in an inflammasome-independent manner |
作者 | |
发表日期 | 2024 |
发表期刊 | BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | NLRP1 Mitochondrial dysfunction NF-kB signaling Lung adenocarcinoma Inflammasome |
其他关键词 | CANCER ; ACTIVATION ; MECHANISMS |
摘要 | NLRP1, the first identified inflammasome-forming sensor, is thought to be involved in cancer, yet its definite function in lung adenocarcinoma (LUAD) remains unclear. Herein, we explored the expression and function of NLRP1 in LUAD. Decreased NLRP1 expression was identified in LUAD, which was associated with a poor prognosis. Overexpression of NLRP1 inhibited tumor growth in vitro and in vivo. Mechanically, this effect was observed regardless of inflammasome activation. Further studies revealed that overexpression of NLRP1 downregulated the phosphorylation of DRP1 and promoted mitochondrial fusion, which was mediated by inhibition of NF-kB activity. NF-kB agonist could neutralize the effect of NLRP1 on mitochondrial dynamics. In addition, LUAD sensitivity to cisplatin was enhanced by decreased mitochondrial fission resulting from up-regulated NLRP1. In conclusion, our findings demonstrated an unexpected role of NLRP1 in LUAD by modulating mitochondrial activities, which provides strong evidence for its potential in LUAD treatment. |
资助项目 | National Natural Science Foundation of China [82073203]; Nurture Projects for Basic Research of Shanghai Chest Hospital [2022YNJCQ05] |
出版者 | ASSOC BRAS DIVULG CIENTIFICA |
ISSN | 0100-879X |
EISSN | 1414-431X |
卷号 | 57 |
DOI | 10.1590/1414-431X2024e13885 |
页数 | 13 |
WOS类目 | Biology ; Medicine, Research & Experimental |
WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Research & Experimental Medicine |
WOS记录号 | WOS:001312363700001 |
收录类别 | SCIE ; PUBMED |
URL | 查看原文 |
PubMed ID | 39258674 |
通讯作者地址 | [Tian, Ling]Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Sch Med, Dept Cent Lab, Shanghai, Peoples R China. ; [Gu, Dian-na]Wenzhou Med Univ, Affiliated Hosp 1, Dept Chemotherapy, Wenzhou, Zhejiang, Peoples R China. |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/218680 |
专题 | 附属第一医院 附属第一医院_放化疗科 |
通讯作者 | Gu, Dian-na; Tian, Ling |
作者单位 | 1.Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Sch Med, Dept Cent Lab, Shanghai, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Chemotherapy, Wenzhou, Zhejiang, Peoples R China |
通讯作者单位 | 附属第一医院; 放化疗科 |
推荐引用方式 GB/T 7714 | Lin, Chen-jing,Tian, Guang-ang,Zhao, Wen-ya,et al. NLRP1 inhibits lung adenocarcinoma growth through mediating mitochondrial dysregulation in an inflammasome-independent manner[J]. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH,2024,57. |
APA | Lin, Chen-jing., Tian, Guang-ang., Zhao, Wen-ya., Tian, Yi., Liu, Yi-ru., ... & Tian, Ling. (2024). NLRP1 inhibits lung adenocarcinoma growth through mediating mitochondrial dysregulation in an inflammasome-independent manner. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 57. |
MLA | Lin, Chen-jing,et al."NLRP1 inhibits lung adenocarcinoma growth through mediating mitochondrial dysregulation in an inflammasome-independent manner".BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH 57(2024). |
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