NLRP1 inhibits lung adenocarcinoma growth through mediating mitochondrial dysregulation in an inflammasome-independent manner

doi:10.1590/1414-431X2024e13885

科研成果详情

题名	NLRP1 inhibits lung adenocarcinoma growth through mediating mitochondrial dysregulation in an inflammasome-independent manner
作者	Lin, Chen-jing 1; Tian, Guang-ang 1; Zhao, Wen-ya 1; Tian, Yi 1; Liu, Yi-ru2; Gu, Dian-na2; Tian, Ling 1
发表日期	2024
发表期刊	BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	NLRP1 Mitochondrial dysfunction NF-kB signaling Lung adenocarcinoma Inflammasome
其他关键词	CANCER ; ACTIVATION ; MECHANISMS
摘要	NLRP1, the first identified inflammasome-forming sensor, is thought to be involved in cancer, yet its definite function in lung adenocarcinoma (LUAD) remains unclear. Herein, we explored the expression and function of NLRP1 in LUAD. Decreased NLRP1 expression was identified in LUAD, which was associated with a poor prognosis. Overexpression of NLRP1 inhibited tumor growth in vitro and in vivo. Mechanically, this effect was observed regardless of inflammasome activation. Further studies revealed that overexpression of NLRP1 downregulated the phosphorylation of DRP1 and promoted mitochondrial fusion, which was mediated by inhibition of NF-kB activity. NF-kB agonist could neutralize the effect of NLRP1 on mitochondrial dynamics. In addition, LUAD sensitivity to cisplatin was enhanced by decreased mitochondrial fission resulting from up-regulated NLRP1. In conclusion, our findings demonstrated an unexpected role of NLRP1 in LUAD by modulating mitochondrial activities, which provides strong evidence for its potential in LUAD treatment.
资助项目	National Natural Science Foundation of China [82073203]; Nurture Projects for Basic Research of Shanghai Chest Hospital [2022YNJCQ05]
出版者	ASSOC BRAS DIVULG CIENTIFICA
ISSN	0100-879X
EISSN	1414-431X
卷号	57
DOI	10.1590/1414-431X2024e13885
页数	13
WOS类目	Biology ; Medicine, Research & Experimental
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Research & Experimental Medicine
WOS记录号	WOS:001312363700001
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	39258674
通讯作者地址	[Tian, Ling]Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Sch Med, Dept Cent Lab, Shanghai, Peoples R China. ; [Gu, Dian-na]Wenzhou Med Univ, Affiliated Hosp 1, Dept Chemotherapy, Wenzhou, Zhejiang, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218680
专题	附属第一医院附属第一医院_放化疗科
通讯作者	Gu, Dian-na; Tian, Ling
作者单位	1.Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Sch Med, Dept Cent Lab, Shanghai, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Chemotherapy, Wenzhou, Zhejiang, Peoples R China
通讯作者单位	附属第一医院; 放化疗科
推荐引用方式 GB/T 7714	Lin, Chen-jing,Tian, Guang-ang,Zhao, Wen-ya,et al. NLRP1 inhibits lung adenocarcinoma growth through mediating mitochondrial dysregulation in an inflammasome-independent manner[J]. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH,2024,57.
APA	Lin, Chen-jing., Tian, Guang-ang., Zhao, Wen-ya., Tian, Yi., Liu, Yi-ru., ... & Tian, Ling. (2024). NLRP1 inhibits lung adenocarcinoma growth through mediating mitochondrial dysregulation in an inflammasome-independent manner. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 57.
MLA	Lin, Chen-jing,et al."NLRP1 inhibits lung adenocarcinoma growth through mediating mitochondrial dysregulation in an inflammasome-independent manner".BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH 57(2024).