Association of unsweetened and sweetened cereal consumption with all-cause and cause-specific mortality: a large prospective population-based cohort study

doi:10.1039/d4fo03761h

科研成果详情

题名	Association of unsweetened and sweetened cereal consumption with all-cause and cause-specific mortality: a large prospective population-based cohort study
作者	Zhang, Lei 1; Ma, Chunhui 2; Huang, Hao 3; Li, Dapeng4; Zhang, Ding 3; Wu, Tianqi 5; Chu, Minjie 1; Hu, Fulan 6
发表日期	2024-09-19
发表期刊	Food and Function 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Sweeteners Biobanks Breakfast cereals Cardiovascular disease Cohort studies Confidence interval Cox's regression model Hazard ratio Observational study Prospectives Whole grains
其他关键词	DOSE-RESPONSE METAANALYSIS ; WHOLE-GRAIN INTAKE ; CARDIOVASCULAR-DISEASE ; FOOD GROUPS ; DIETARY FIBER ; HEALTH ; RISK ; BEVERAGES ; BENEFITS ; SUGARS
摘要	Background & aims: Although previous observational studies have suggested an association between whole grain consumption (including breakfast cereals) and a reduced risk of death, no study has explored in detail the association between consumption of cereal with or without added sweeteners and death. We therefore aimed to evaluate the association between unsweetened, sugar-sweetened, and artificially sweetened cereals and all-cause and cause-specific mortality. Methods: We conducted a prospective cohort study of 186 419 UK Biobank participants who met the inclusion criteria for this study. Participants with baseline demographic, lifestyle, dietary, and clinical data were recruited from 2006 to 2010 and followed up until 2023. The intake of unsweetened, sugar-sweetened, or artificially sweetened cereals was estimated through repeated 24 hour dietary recalls. The non-linear relationships between daily dosage of cereal and all-cause, cancer-specific, and cardiovascular disease (CVD)-specific mortality were calculated using a restricted cubic spline curve. Hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and cause-specific mortality were calculated using Cox regression models. Results: During a median follow-up of 13.6 years, 11 351 all-cause deaths were recorded, including 6176 cancer deaths and 2126 CVD deaths. Cox regression models with restricted cubic splines showed a non-linear association between unsweetened cereals and all-cause and cancer-specific mortality. Compared with non-consumers, consumers of different amounts of unsweetened cereals (0 to 0.5, 0.5 to 1.5, and >1.5 bowls per day) had lower risks of all-cause mortality in the multivariate Cox models, with respective HRs of 0.89 (95%CI: 0.84-0.95), 0.90 (95%CI: 0.86-0.94), and 0.89 (95%CI: 0.82-0.97). However, no association was observed between consumption of sugar or artificially sweetened cereals and the risk of mortality. When cereals were divided into those with or without dried fruit, the findings were consistent with our primary results. Conclusions: Moderate consumption of unsweetened cereals was associated with a reduced risk of all-cause mortality, suggesting caution in consuming cereals with added sugar or artificial sweeteners.
资助项目	Shenzhen University [JCYJ20190808111817192, JCYJ20210324093807020]; Science and Technology Development Foundation of Shenzhen [2019123, QNJS0160, 81680]; Scientific Research Initiation Foundation for Young Teachers of Shenzhen University
出版者	ROYAL SOC CHEMISTRY
ISSN	2042-6496
EISSN	2042-650X
卷号	15 期号:19 页码:10151-10162
DOI	10.1039/d4fo03761h
页数	12
WOS类目	Biochemistry & Molecular Biology ; Food Science & Technology
WOS研究方向	Biochemistry & Molecular Biology ; Food Science & Technology
WOS记录号	WOS:001316169400001
收录类别	SCIE ; PUBMED ; EI ; SCOPUS
EI入藏号	20243917092797
EI主题词	Artificial sweeteners
EI分类号	822.3 Food Products
URL	查看原文
PubMed ID	392978
SCOPUSEID	2-s2.0-85204644928
通讯作者地址	[Chu, Minjie]Nantong Univ, Sch Publ Hlth, Dept Epidemiol, Nantong 226019, Jiangsu, Peoples R China. ; [Hu, Fulan]Shenzhen Univ, Sch Publ Hlth, Dept Biostat & Epidemiol, Med Sch, Shenzhen 518055, Guangdong, Peoples R China.
Scopus学科分类	Food Science
SCOPUS_ID	SCOPUS_ID:85204644928
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218604
专题	第一临床医学院（信息与工程学院）、附属第一医院_流行病学
通讯作者	Chu, Minjie; Hu, Fulan
作者单位	1.Nantong Univ, Sch Publ Hlth, Dept Epidemiol, Nantong 226019, Jiangsu, Peoples R China; 2.Nantong Univ, Affiliated Hosp 2, Nantong Peoples Hosp 1, Dept Thorac Surg, Nantong 226001, Jiangsu, Peoples R China; 3.Zunyi Med Univ, Dept Prevent Med, Zhuhai Campus, Zhuhai 519000, Guangdong, Peoples R China; 4.Wenzhou Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Wenzhou 325000, Zhejiang, Peoples R China; 5.Nantong Univ, Sch Med, Nantong 226019, Jiangsu, Peoples R China; 6.Shenzhen Univ, Sch Publ Hlth, Dept Biostat & Epidemiol, Med Sch, Shenzhen 518055, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Lei,Ma, Chunhui,Huang, Hao,et al. Association of unsweetened and sweetened cereal consumption with all-cause and cause-specific mortality: a large prospective population-based cohort study[J]. Food and Function,2024,15(19):10151-10162.
APA	Zhang, Lei., Ma, Chunhui., Huang, Hao., Li, Dapeng., Zhang, Ding., ... & Hu, Fulan. (2024). Association of unsweetened and sweetened cereal consumption with all-cause and cause-specific mortality: a large prospective population-based cohort study. Food and Function, 15(19), 10151-10162.
MLA	Zhang, Lei,et al."Association of unsweetened and sweetened cereal consumption with all-cause and cause-specific mortality: a large prospective population-based cohort study".Food and Function 15.19(2024):10151-10162.