Associations between cuprotosis-related genes and the spectrum of metabolic dysfunction-associated fatty liver disease: An exploratory study

doi:10.1111/dom.15946

科研成果详情

题名	Associations between cuprotosis-related genes and the spectrum of metabolic dysfunction-associated fatty liver disease: An exploratory study
作者	Yuan, Hai-Yang1; Liu, Wen-Yue2; Feng, Gong 3; Chen, Sui-Dan4; Jin, Xin-Zhe 5; Chen, Li-Li 1; Song, Zi-Jun 6; Li, Ke 7,8; Byrne, Christopher D.9,10; Targher, Giovanni 11; Tian, Na1; Li, Gang 12; Zhang, Xin-Lei1; George, Jacob 13,14; Zhou, Meng7,8; Wang, Fudi 6; Zheng, Ming-Hua1,15,16
发表日期	2024-09-16
发表期刊	DIABETES OBESITY & METABOLISM 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	bulk RNA-seq cuprotosis genome-wide association study hepatocellular carcinoma metabolic dysfunction-associated fatty liver disease sing-cell RNA-seq
其他关键词	COPPER ; IRON ; RISK
摘要	Aims: To explore the associations between cuprotosis-related genes (CRGs) acrossdifferent stages of liver disease in metabolic dysfunction-associated fatty liver disease(MAFLD), including hepatocellular carcinoma (HCC). Materials and Methods: We analysed several bulk RNA sequencing datasets frompatients with MAFLD (n=331) and MAFLD-related HCC (n=271) and two MAFLDsingle-cell RNA sequencing datasets. To investigate the associations between CRGsand MAFLD, we performed differential correlation, logistic regression and functionalenrichment analyses. We also validated the findings in an independent WenzhouPERSONS cohort of MAFLD patients (n=656) used for a genome-wide associationstudy (GWAS). Results:GLS,GCSHandATP7Bgenes showed significant differences across theMAFLD spectrum and were significantly associated with liver fibrosis stages.GLSwasclosely associated with fibrosis stages in patients with MAFLD and those withMAFLD-related HCC.GLSis predominantly expressed in monocytes and T cells in MAFLD. During the progression of metabolic dysfunction-associated fatty liver tometabolic-associated steatohepatitis,GLSexpression in T cells decreased. GWASrevealed that multiple single nucleotide polymorphisms inGLSwere associated withclinical indicators of MAFLD. Conclusions:GLSmay contribute to liver inflammation and fibrosis in MAFLD mainlythrough cuprotosis and T-cell activation, promoting the progression of MAFLD toHCC. These findings suggest that cuprotosis may play a role in MAFLD progression,potentially providing new insights into MAFLD pathogenesis.
资助项目	The National Natural Science Foundation of China [82070588, 82370577]; National Natural Science Foundation of China; School of Medicine, University of Verona, Verona, Italy [NIHR203319]; Southampton NIHR Biomedical Research Centre; Robert W. Storr Bequest to the Sydney Medical Foundation [APP1053206, APP2001692, APP1107178, APP1108422, APP1196492]; National Health and Medical Research Council of Australia (NHMRC) Program Grant [2021/ATRG2028]; Cancer Institute, NSW
出版者	WILEY
ISSN	1462-8902
EISSN	1463-1326
DOI	10.1111/dom.15946
页数	19
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:001314034500001
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	39285685
通讯作者地址	[Zheng, Ming-Hua]Wenzhou Med Univ, Affiliated Hosp 1, Dept Hepatol, NAFLD Res Ctr, 2 Fuxue Lane, Wenzhou 325000, Peoples R China. ; [Wang, Fudi]Zhejiang Univ, Affiliated Hosp 1, Inst Translat Med, Sch Publ Hlth,Sch Med, Hangzhou 310058, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/218560
专题	附属第一医院附属第一医院_病理科附属第一医院_检验科眼视光学院（生物医学工程学院）、附属眼视光医院附属第一医院_内分泌科眼视光学院（生物医学工程学院）、附属眼视光医院_医学工程系
通讯作者	Wang, Fudi; Zheng, Ming-Hua
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Hepatol, NAFLD Res Ctr, 2 Fuxue Lane, Wenzhou 325000, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Endocrinol, Wenzhou, Peoples R China; 3.Xian Med Univ, Xian, Peoples R China; 4.Wenzhou Med Univ, Affiliated Hosp 1, Dept Pathol, Wenzhou, Peoples R China; 5.Wenzhou Med Univ, Affiliated Hosp 1, Dept Lab Med, Wenzhou, Peoples R China; 6.Zhejiang Univ, Affiliated Hosp 1, Inst Translat Med, Sch Publ Hlth,Sch Med, Hangzhou 310058, Peoples R China; 7.Wenzhou Med Univ, Sch Ophthalmol & Optometry, Sch Biomed Engn, Wenzhou, Peoples R China; 8.Wenzhou Med Univ, Eye Hosp, Wenzhou, Peoples R China; 9.Univ Hosp Southampton, Southampton Natl Inst Hlth & Care Res, Biomed Res Ctr, Southampton, England; 10.Univ Southampton, Southampton Gen Hosp, Southampton, England; 11.IRCCS Sacro Cuore Don Calabria Hosp, Metab Dis Res Unit, Negrar Di Valpolicella, Italy; 12.Jining 1 Peoples Hosp, Dept Infect Dis, Jining, Peoples R China; 13.Westmead Hosp, Storr Liver Ctr, Westmead, Australia; 14.Univ Sydney, Westmead, Australia; 15.Wenzhou Med Univ, Inst Hepatol, Wenzhou, Peoples R China; 16.Key Lab Diag & Treatment Dev Chron Liver Dis Zheji, Wenzhou, Peoples R China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Yuan, Hai-Yang,Liu, Wen-Yue,Feng, Gong,et al. Associations between cuprotosis-related genes and the spectrum of metabolic dysfunction-associated fatty liver disease: An exploratory study[J]. DIABETES OBESITY & METABOLISM,2024.
APA	Yuan, Hai-Yang., Liu, Wen-Yue., Feng, Gong., Chen, Sui-Dan., Jin, Xin-Zhe., ... & Zheng, Ming-Hua. (2024). Associations between cuprotosis-related genes and the spectrum of metabolic dysfunction-associated fatty liver disease: An exploratory study. DIABETES OBESITY & METABOLISM.
MLA	Yuan, Hai-Yang,et al."Associations between cuprotosis-related genes and the spectrum of metabolic dysfunction-associated fatty liver disease: An exploratory study".DIABETES OBESITY & METABOLISM (2024).