题名 | Identification of a novel histone acetylation-related long non-coding RNA model combined with qRT-PCR experiments for prognosis and therapy in gastric cancer |
作者 | |
发表日期 | 2024-09-15 |
发表期刊 | Heliyon 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | Gastric cancer (GC) Histone acetylation Long non-coding RNA Predictive model Prognostic |
其他关键词 | EXPRESSION ; SIGNATURES ; TUMORS |
摘要 | Gastric cancer (GC) is considered a global health crisis due to the scarcity of early diagnostic methods. Numerous studies have substantiated the involvement of histone acetylation imbalance in the progression of diverse tumor types. The potential roles of long non-coding RNA (lncRNA) in improving prognostic, predictive as well as therapeutic approaches in cancers have made it a major hotspot in recent years. Nevertheless, existent studies have never concerned the prognostic and clinical value of histone acetylation-related lncRNAs (HARlncs) in GC. Based on the aforementioned rationale, we developed a prognostic model incorporating four HARlncs—AC114730.1, AL445250.1, LINC01778, and AL163953.1—which demonstrated potential as an independent predictor of prognosis. Subsequently, GC patients were stratified into high-risk and low-risk groups. The low-risk group exhibited significantly higher overall survival (OS) compared to the high-risk group. Based on the analyses of the tumor microenvironment (TME) and immune responses, significant differences were observed between the two risk groups in terms of immune cell infiltration, immune checkpoint (ICP) expression, and other TME alterations. Furthermore, the sensitivity of GC patients to some chemotherapeutic drugs and the discrepant biological behaviors of three tumor clusters were studied in this model. In summary, we developed an effective HARlncs model with the objective of offering novel prognostic prediction methods and identifying potential therapeutic targets for GC patients. |
资助项目 | Ningbo Natural Science Fund [2019A610335]; Zhejiang Province Medical Project [2020KY248]; Ningbo Public Welfare Science and Technology Project [202002N3163]; Zhejiang Province Traditional Chinese Medicine Project [2020ZB214] |
出版者 | CELL PRESS |
ISSN | 2405-8440 |
EISSN | 2405-8440 |
卷号 | 10期号:17 |
DOI | 10.1016/j.heliyon.2024.e36615 |
页数 | 15 |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
WOS记录号 | WOS:001301675100001 |
收录类别 | SCOPUS ; SCIE ; PUBMED |
URL | 查看原文 |
PubMed ID | 39263162 |
SCOPUSEID | 2-s2.0-85201761496 |
通讯作者地址 | [Guo, Yangyang]Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,Taizhou,318000,China ; [Wang, Xiaowu]Department of Burns and Skin Repair Surgery,The Third Affiliated Hospital of Wenzhou Medical University,Ruian,325200,China ; [Qu, Liangchen]Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,Taizhou,318000,China |
Scopus学科分类 | Multidisciplinary |
SCOPUS_ID | SCOPUS_ID:85201761496 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/217575 |
专题 | 附属第一医院 第一临床医学院(信息与工程学院)、附属第一医院 附属台州医院 其他_附属第三医院(瑞安市人民医院) 其他_附属台州医院(浙江省台州医院) |
通讯作者 | Guo, Yangyang; Wang, Xiaowu; Qu, Liangchen |
作者单位 | 1.Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,Taizhou,318000,China; 3.Department of Burns and Skin Repair Surgery,The Third Affiliated Hospital of Wenzhou Medical University,Ruian,325200,China; 4.Department of Thyroid and Surgery,The First Affiliated Hospital of Ningbo University,Ningbo,315000,China |
第一作者单位 | 附属第一医院; 第一临床医学院(信息与工程学院)、附属第一医院; 附属台州医院(浙江省台州医院); 附属台州医院 |
通讯作者单位 | 附属台州医院(浙江省台州医院); 附属台州医院; 附属第三医院(瑞安市人民医院) |
第一作者的第一单位 | 附属第一医院 |
推荐引用方式 GB/T 7714 | Wu, Zhixuan,Yang, Xuejia,Yuan, Ziwei,et al. Identification of a novel histone acetylation-related long non-coding RNA model combined with qRT-PCR experiments for prognosis and therapy in gastric cancer[J]. Heliyon,2024,10(17). |
APA | Wu, Zhixuan, Yang, Xuejia, Yuan, Ziwei, Guo, Yangyang, Wang, Xiaowu, & Qu, Liangchen. (2024). Identification of a novel histone acetylation-related long non-coding RNA model combined with qRT-PCR experiments for prognosis and therapy in gastric cancer. Heliyon, 10(17). |
MLA | Wu, Zhixuan,et al."Identification of a novel histone acetylation-related long non-coding RNA model combined with qRT-PCR experiments for prognosis and therapy in gastric cancer".Heliyon 10.17(2024). |
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