科研成果详情

题名Identification of a novel histone acetylation-related long non-coding RNA model combined with qRT-PCR experiments for prognosis and therapy in gastric cancer
作者
发表日期2024-09-15
发表期刊Heliyon   影响因子和分区
语种英语
原始文献类型Article
关键词Gastric cancer (GC) Histone acetylation Long non-coding RNA Predictive model Prognostic
其他关键词EXPRESSION ; SIGNATURES ; TUMORS
摘要Gastric cancer (GC) is considered a global health crisis due to the scarcity of early diagnostic methods. Numerous studies have substantiated the involvement of histone acetylation imbalance in the progression of diverse tumor types. The potential roles of long non-coding RNA (lncRNA) in improving prognostic, predictive as well as therapeutic approaches in cancers have made it a major hotspot in recent years. Nevertheless, existent studies have never concerned the prognostic and clinical value of histone acetylation-related lncRNAs (HARlncs) in GC. Based on the aforementioned rationale, we developed a prognostic model incorporating four HARlncs—AC114730.1, AL445250.1, LINC01778, and AL163953.1—which demonstrated potential as an independent predictor of prognosis. Subsequently, GC patients were stratified into high-risk and low-risk groups. The low-risk group exhibited significantly higher overall survival (OS) compared to the high-risk group. Based on the analyses of the tumor microenvironment (TME) and immune responses, significant differences were observed between the two risk groups in terms of immune cell infiltration, immune checkpoint (ICP) expression, and other TME alterations. Furthermore, the sensitivity of GC patients to some chemotherapeutic drugs and the discrepant biological behaviors of three tumor clusters were studied in this model. In summary, we developed an effective HARlncs model with the objective of offering novel prognostic prediction methods and identifying potential therapeutic targets for GC patients.
资助项目Ningbo Natural Science Fund [2019A610335]; Zhejiang Province Medical Project [2020KY248]; Ningbo Public Welfare Science and Technology Project [202002N3163]; Zhejiang Province Traditional Chinese Medicine Project [2020ZB214]
出版者CELL PRESS
ISSN2405-8440
EISSN2405-8440
卷号10期号:17
DOI10.1016/j.heliyon.2024.e36615
页数15
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
WOS记录号WOS:001301675100001
收录类别SCOPUS ; SCIE ; PUBMED
URL查看原文
PubMed ID39263162
SCOPUSEID2-s2.0-85201761496
通讯作者地址[Guo, Yangyang]Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,Taizhou,318000,China ; [Wang, Xiaowu]Department of Burns and Skin Repair Surgery,The Third Affiliated Hospital of Wenzhou Medical University,Ruian,325200,China ; [Qu, Liangchen]Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,Taizhou,318000,China
Scopus学科分类Multidisciplinary
SCOPUS_IDSCOPUS_ID:85201761496
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/217575
专题附属第一医院
第一临床医学院(信息与工程学院)、附属第一医院
附属台州医院
其他_附属第三医院(瑞安市人民医院)
其他_附属台州医院(浙江省台州医院)
通讯作者Guo, Yangyang; Wang, Xiaowu; Qu, Liangchen
作者单位
1.Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China;
2.Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,Taizhou,318000,China;
3.Department of Burns and Skin Repair Surgery,The Third Affiliated Hospital of Wenzhou Medical University,Ruian,325200,China;
4.Department of Thyroid and Surgery,The First Affiliated Hospital of Ningbo University,Ningbo,315000,China
第一作者单位附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院;  附属台州医院(浙江省台州医院);  附属台州医院
通讯作者单位附属台州医院(浙江省台州医院);  附属台州医院;  附属第三医院(瑞安市人民医院)
第一作者的第一单位附属第一医院
推荐引用方式
GB/T 7714
Wu, Zhixuan,Yang, Xuejia,Yuan, Ziwei,et al. Identification of a novel histone acetylation-related long non-coding RNA model combined with qRT-PCR experiments for prognosis and therapy in gastric cancer[J]. Heliyon,2024,10(17).
APA Wu, Zhixuan, Yang, Xuejia, Yuan, Ziwei, Guo, Yangyang, Wang, Xiaowu, & Qu, Liangchen. (2024). Identification of a novel histone acetylation-related long non-coding RNA model combined with qRT-PCR experiments for prognosis and therapy in gastric cancer. Heliyon, 10(17).
MLA Wu, Zhixuan,et al."Identification of a novel histone acetylation-related long non-coding RNA model combined with qRT-PCR experiments for prognosis and therapy in gastric cancer".Heliyon 10.17(2024).

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