MUL1 identified as mitochondria-linked biomarker promoting cisplatin resistance in OC cells

doi:10.1016/j.gene.2024.148841

科研成果详情

题名	MUL1 identified as mitochondria-linked biomarker promoting cisplatin resistance in OC cells
作者	Liu, Lixiao 1; Zou, Chengyang5; Shen, Jingtian2; Huang, Rong 2; Zhang, Fubin 1; Du, Yongming 1; Luo, Xishao 2; Yang, Aiwu 6; Zhang, Jinsan3,4; Guan, Yutao 1; Yan, Xiaojian2
发表日期	2024-12-20
发表期刊	Gene 影响因子和分区
语种	英语
原始文献类型	Article
关键词	OC MUL1 TCGA Platinum resistance Organoid culture
其他关键词	E3 UBIQUITIN LIGASE ; CANCER STATISTICS ; INHIBITION ; METABOLISM ; APOPTOSIS
摘要	Ovarian cancer (OC) ranks among the prevalent tumors affecting the female reproductive system. The aim of this study was to evaluate mitochondria-associated platinum resistance genes using organoid models. Univariate Cox regression, LASSO and multivariate Cox regression analyses were performed on The Cancer Genome Atlas (TCGA) database to construct 2-gene prognostic signature (MUL1 and SSBP1), and GSE26712 dataset was used for external validation. In addition, the relationship between MUL1 and platinum resistance was examined by organoid culture, lentiviral transduction, CCK8 assay, and Western blot. The results showed that patients in the high-risk group exhibited significantly worse OS (P = 0.002, P = 0.017). Drug sensitivity analysis revealed that platinum resistance increased with the upregulation of MUL1 expression (Cor = 0.5154, P = 0.02). Our experimental findings demonstrated that knockout of the MUL1 gene significantly increased apoptosis and enhanced the sensitivity of the OC cell line A2780 to cisplatin. Through this study, we have provided strong evidence for further research on prognostic risk factors and individualized treatment in OC patients, and provided new insights into addressing platinum resistance in OC.
资助项目	Science and Technology Programs of Ningbo [KY2021-013]; Medical and Health Science and Technology Program of Zhejiang Province, China [202003N4289]; Science and Technology Programs of Wenzhou [2021440659]; Provincial natural Science Foundation of Zhejiang [Y2020090]
出版者	ELSEVIER
ISSN	0378-1119
EISSN	1879-0038
卷号	930
DOI	10.1016/j.gene.2024.148841
页数	10
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
WOS记录号	WOS:001296822300001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	39134101
SCOPUSEID	2-s2.0-85201302516
通讯作者地址	[Guan, Yutao]Ningbo Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Ningbo, Zhejiang, Peoples R China. ; [Yan, Xiaojian]Wenzhou Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Wenzhou, Zhejiang, Peoples R China. ; [Zhang, Jinsan]Wenzhou Med Univ, Dept Med Res Ctr, Wenzhou, Zhejiang, Peoples R China. ; [Zhang, Jinsan]Wenzhou Med Univ, Affiliated Hosp 1, Dept Pulm Med, Wenzhou, Zhejiang, Peoples R China.
Scopus学科分类	Genetics
SCOPUS_ID	SCOPUS_ID:85201302516
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/217417
专题	附属第一医院附属第一医院_产科附属第一医院_呼吸内科其他_附属第五医院（丽水市中心医院）
通讯作者	Zhang, Jinsan; Guan, Yutao; Yan, Xiaojian
作者单位	1.Ningbo Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Ningbo, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Wenzhou, Zhejiang, Peoples R China; 3.Wenzhou Med Univ, Dept Med Res Ctr, Wenzhou, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Affiliated Hosp 1, Dept Pulm Med, Wenzhou, Zhejiang, Peoples R China; 5.Wenzhou Med Univ, Zhejiang Univ, Lishui Hosp, Affiliated Hosp 5,Affiliated Cent Hosp Lishui, Lishui 323000, Peoples R China; 6.Wenzhou Peoples Hosp, Dept Obstet & Gynecol, Wenzhou, Zhejiang, Peoples R China
通讯作者单位	附属第一医院; 产科; 温州医科大学; 呼吸内科
推荐引用方式 GB/T 7714	Liu, Lixiao,Zou, Chengyang,Shen, Jingtian,et al. MUL1 identified as mitochondria-linked biomarker promoting cisplatin resistance in OC cells[J]. Gene,2024,930.
APA	Liu, Lixiao., Zou, Chengyang., Shen, Jingtian., Huang, Rong., Zhang, Fubin., ... & Yan, Xiaojian. (2024). MUL1 identified as mitochondria-linked biomarker promoting cisplatin resistance in OC cells. Gene, 930.
MLA	Liu, Lixiao,et al."MUL1 identified as mitochondria-linked biomarker promoting cisplatin resistance in OC cells".Gene 930(2024).