Macrophage polarization and its impact on idiopathic pulmonary fibrosis

doi:10.3389/fimmu.2024.1444964

科研成果详情

题名	Macrophage polarization and its impact on idiopathic pulmonary fibrosis
作者	Ge, Zhouling 1; Chen, Yong2,3; Ma, Leikai 2; Hu, Fangjun 1; Xie, Lubin 1,4,5
发表日期	2024-07-26
发表期刊	FRONTIERS IN IMMUNOLOGY 影响因子和分区
语种	英语
原始文献类型	Review
关键词	idiopathic pulmonary fibrosis macrophage polarization M1 macrophages M2 macrophages fibrosis inflammation
其他关键词	ACUTE LUNG INJURY ; ALTERNATIVE ACTIVATION ; EPIGENETIC REGULATION ; METABOLIC-REGULATION ; GENE-EXPRESSION ; ER STRESS ; SUCCINATE-DEHYDROGENASE ; SURFACE-TOPOGRAPHY ; INNATE IMMUNITY ; TNF-ALPHA
摘要	Idiopathic pulmonary fibrosis (IPF) is a lung disease that worsens over time, causing fibrosis in the lungs and ultimately resulting in respiratory failure and a high risk of death. Macrophages play a crucial role in the immune system, showing flexibility by transforming into either pro-inflammatory (M1) or anti-inflammatory (M2) macrophages when exposed to different stimuli, ultimately impacting the development of IPF. Recent research has indicated that the polarization of macrophages is crucial in the onset and progression of IPF. M1 macrophages secrete inflammatory cytokines and agents causing early lung damage and fibrosis, while M2 macrophages support tissue healing and fibrosis by releasing anti-inflammatory cytokines. Developing novel treatments for IPF relies on a thorough comprehension of the processes involved in macrophage polarization in IPF. The review outlines the regulation of macrophage polarization and its impact on the development of IPF, with the goal of investigating the possible therapeutic benefits of macrophage polarization in the advancement of IPF.
资助项目	Zhejiang Provincial natural scientific [LQ21H010002]; Wenzhou Science and Technology Bureau [Y20240265]
出版者	FRONTIERS MEDIA SA
ISSN	1664-3224
卷号	15
DOI	10.3389/fimmu.2024.1444964
页数	18
WOS类目	Immunology
WOS研究方向	Immunology
WOS记录号	WOS:001286188800001
收录类别	SCIE
PubMed ID	39131154
通讯作者地址	[Xie, Lubin]Shanghai Univ, Wenzhou Peoples Hosp, Dept Resp Med, Affiliated Hosp 3, Wenzhou, Peoples R China. ; [Xie, Lubin]Wenzhou Med Univ, Affiliated Hosp 2, Dept Gynecol & Obstet, Wenzhou, Peoples R China. ; [Xie, Lubin]Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/217392
专题	附属第一医院_麻醉科第二临床医学院，附属第二医院、育英儿童医院附属第二医院_妇产科
通讯作者	Xie, Lubin
作者单位	1.Shanghai Univ, Wenzhou Peoples Hosp, Dept Resp Med, Affiliated Hosp 3, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Wenzhou, Peoples R China; 3.Tongji Univ, Shanghai Pulm Hosp, Dept Anesthesiol, Shanghai, Peoples R China; 4.Wenzhou Med Univ, Affiliated Hosp 2, Dept Gynecol & Obstet, Wenzhou, Peoples R China; 5.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China
通讯作者单位	附属第二医院_妇产科; 第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Ge, Zhouling,Chen, Yong,Ma, Leikai,et al. Macrophage polarization and its impact on idiopathic pulmonary fibrosis[J]. FRONTIERS IN IMMUNOLOGY,2024,15.
APA	Ge, Zhouling, Chen, Yong, Ma, Leikai, Hu, Fangjun, & Xie, Lubin. (2024). Macrophage polarization and its impact on idiopathic pulmonary fibrosis. FRONTIERS IN IMMUNOLOGY, 15.
MLA	Ge, Zhouling,et al."Macrophage polarization and its impact on idiopathic pulmonary fibrosis".FRONTIERS IN IMMUNOLOGY 15(2024).