科研成果详情

题名Decellularized Tumor Tissues Integrated with Polydopamine for Wound Healing
作者
发表日期2024-08-09
发表期刊RESEARCH   影响因子和分区
语种英语
原始文献类型Article
关键词Biocompatibility Scaffolds Scaffolds (biology) Tissue regeneration Bioprinting Decellularized Growth factor Human colon Natural biomaterials Photothermal effects Polydopamine Tissue repair Tumour tissue Wound healing
摘要Natural biomaterials have been showing extensive potential in wound healing; attempts therefore focus on productions achieving both antimicrobial and tissue regenerative abilities. Here, we construct a decellularized human colon tumor (DHCT)-derived scaffold for wound remolding via microfluidic bioprinting. The DHCT retains a series of growth factors, fibrin, and the collagen configuration, that favor tissue repair and reconstruction. Specifically, the scaffold shows superior abilities in cell migration and angiogenesis. The biocompatible scaffold is also imparted with tissue adhesion ability and photothermal effect due to the coating of biologically derived polydopamine on the surface. The strong photothermal effect under near- infrared irradiation also present the scaffold with an antibacterial rate exceeding 90%. Furthermore, in vivo experiments convinced that the polydopamine-integrated DHCT scaffold can markedly expedite the healing process of acute extensive wounds. These findings indicate that composite materials derived from natural tumors have substantial potential in pertinent clinical applications.
资助项目National Natural Science Foundation of China [81972261, 82272172]; Medical Health Science and Technology Key Project of Zhejiang Provincial and Ministry Health Commission [WKJ-ZJ-2322]
出版者AMER ASSOC ADVANCEMENT SCIENCE
ISSN2096-5168
EISSN2639-5274
卷号7
DOI10.34133/research.0445
页数11
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
WOS记录号WOS:001290238700001
收录类别SCIE ; PUBMED ; EI
EI入藏号20243516948834
EI主题词Tumors
EI分类号101.1 ; 102.1.1 ; 103.2 ; 405.1 Construction Equipment
URL查看原文
PubMed ID39109247
通讯作者地址[Sun, Weijian]Wenzhou Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 2, Wenzhou 325027, Peoples R China. ; [Wang, Jinglin]Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp, Dept Gen Surg,Med Sch,Div Hepatobiliary & Transpla, Nanjing 210008, Peoples R China. ; [Yu, Yunru]Abo Akad Univ, Pharmaceut Sci Lab, Turku 20520, Finland. ; [Chen, Xiaolei]Wenzhou Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China.
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/217373
专题附属第二医院
附属第一医院
第二临床医学院、附属第二医院、育英儿童医院
附属第一医院_胃肠外科
附属第二医院_胃肠外科
通讯作者Yu, Yunru; Wang, Jinglin; Chen, Xiaolei; Sun, Weijian
作者单位
1.Wenzhou Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 2, Wenzhou 325027, Peoples R China;
2.Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp, Dept Gen Surg,Med Sch,Div Hepatobiliary & Transpla, Nanjing 210008, Peoples R China;
3.Abo Akad Univ, Pharmaceut Sci Lab, Turku 20520, Finland;
4.Wenzhou Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China
第一作者单位附属第二医院;  第二临床医学院,附属第二医院、育英儿童医院;  胃肠外科
通讯作者单位附属第二医院;  第二临床医学院,附属第二医院、育英儿童医院;  胃肠外科;  附属第一医院;  胃肠外科
第一作者的第一单位附属第二医院
推荐引用方式
GB/T 7714
Li, Hongzheng,Lin, Xiang,Rao, Shangrui,et al. Decellularized Tumor Tissues Integrated with Polydopamine for Wound Healing[J]. RESEARCH,2024,7.
APA Li, Hongzheng., Lin, Xiang., Rao, Shangrui., Zhou, Gongting., Meng, Letian., ... & Sun, Weijian. (2024). Decellularized Tumor Tissues Integrated with Polydopamine for Wound Healing. RESEARCH, 7.
MLA Li, Hongzheng,et al."Decellularized Tumor Tissues Integrated with Polydopamine for Wound Healing".RESEARCH 7(2024).

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