Decellularized Tumor Tissues Integrated with Polydopamine for Wound Healing

doi:10.34133/research.0445

科研成果详情

题名	Decellularized Tumor Tissues Integrated with Polydopamine for Wound Healing
作者	Li, Hongzheng1; Lin, Xiang 2,3; Rao, Shangrui 1; Zhou, Gongting1; Meng, Letian1; Yu, Yunru 3; Wang, Jinglin 2; Chen, Xiaolei 4; Sun, Weijian1
发表日期	2024-08-09
发表期刊	RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Biocompatibility Scaffolds Scaffolds (biology) Tissue regeneration Bioprinting Decellularized Growth factor Human colon Natural biomaterials Photothermal effects Polydopamine Tissue repair Tumour tissue Wound healing
摘要	Natural biomaterials have been showing extensive potential in wound healing; attempts therefore focus on productions achieving both antimicrobial and tissue regenerative abilities. Here, we construct a decellularized human colon tumor (DHCT)-derived scaffold for wound remolding via microfluidic bioprinting. The DHCT retains a series of growth factors, fibrin, and the collagen configuration, that favor tissue repair and reconstruction. Specifically, the scaffold shows superior abilities in cell migration and angiogenesis. The biocompatible scaffold is also imparted with tissue adhesion ability and photothermal effect due to the coating of biologically derived polydopamine on the surface. The strong photothermal effect under near- infrared irradiation also present the scaffold with an antibacterial rate exceeding 90%. Furthermore, in vivo experiments convinced that the polydopamine-integrated DHCT scaffold can markedly expedite the healing process of acute extensive wounds. These findings indicate that composite materials derived from natural tumors have substantial potential in pertinent clinical applications.
资助项目	National Natural Science Foundation of China [81972261, 82272172]; Medical Health Science and Technology Key Project of Zhejiang Provincial and Ministry Health Commission [WKJ-ZJ-2322]
出版者	AMER ASSOC ADVANCEMENT SCIENCE
ISSN	2096-5168
EISSN	2639-5274
卷号	7
DOI	10.34133/research.0445
页数	11
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:001290238700001
收录类别	SCIE ; PUBMED ; EI
EI入藏号	20243516948834
EI主题词	Tumors
EI分类号	101.1 ; 102.1.1 ; 103.2 ; 405.1 Construction Equipment
URL	查看原文
PubMed ID	39109247
通讯作者地址	[Sun, Weijian]Wenzhou Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 2, Wenzhou 325027, Peoples R China. ; [Wang, Jinglin]Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp, Dept Gen Surg,Med Sch,Div Hepatobiliary & Transpla, Nanjing 210008, Peoples R China. ; [Yu, Yunru]Abo Akad Univ, Pharmaceut Sci Lab, Turku 20520, Finland. ; [Chen, Xiaolei]Wenzhou Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/217373
专题	附属第二医院附属第一医院第二临床医学院、附属第二医院、育英儿童医院附属第一医院_胃肠外科附属第二医院_胃肠外科
通讯作者	Yu, Yunru; Wang, Jinglin; Chen, Xiaolei; Sun, Weijian
作者单位	1.Wenzhou Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 2, Wenzhou 325027, Peoples R China; 2.Nanjing Univ, Nanjing Drum Tower Hosp, Affiliated Hosp, Dept Gen Surg,Med Sch,Div Hepatobiliary & Transpla, Nanjing 210008, Peoples R China; 3.Abo Akad Univ, Pharmaceut Sci Lab, Turku 20520, Finland; 4.Wenzhou Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China
第一作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 胃肠外科
通讯作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 胃肠外科; 附属第一医院; 胃肠外科
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Li, Hongzheng,Lin, Xiang,Rao, Shangrui,et al. Decellularized Tumor Tissues Integrated with Polydopamine for Wound Healing[J]. RESEARCH,2024,7.
APA	Li, Hongzheng., Lin, Xiang., Rao, Shangrui., Zhou, Gongting., Meng, Letian., ... & Sun, Weijian. (2024). Decellularized Tumor Tissues Integrated with Polydopamine for Wound Healing. RESEARCH, 7.
MLA	Li, Hongzheng,et al."Decellularized Tumor Tissues Integrated with Polydopamine for Wound Healing".RESEARCH 7(2024).